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P46831

- ACEA_MYCLE

UniProt

P46831 - ACEA_MYCLE

Protein

Isocitrate lyase

Gene

aceA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway By similarity.By similarity

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Cofactori

    Divalent cations.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei211 – 2111PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:aceA
    Ordered Locus Names:ML1985
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1985.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 606606Isocitrate lyasePRO_0000068778Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML1985.

    Structurei

    3D structure databases

    ProteinModelPortaliP46831.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    HOGENOMiHOG000238475.
    KOiK01637.
    OrthoDBiEOG689HMX.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 2 hits.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIMDTNTEV HTLFTQEVAA TQQYFDDPRF AGIIRLYTAR QVVEQRGTIP    50
    TDYTVARDAA TAFYARLREL FAAGKSVTTF GPYSPGQAVS LKRMGIEAIY 100
    LGGWATSAKG SITEDPGPDL ASYPLSQVPD DAAVLVRALL AADRNQQYLR 150
    LHMTEQQRAA TPAYDYRPFI IADADTGHGG DSHVRNLIRR FVEIGVPGYH 200
    IEDQRPGTKK CGHQGGKVLV PSDEQIKRLN AARFQLDIMR VPGIIVARTD 250
    AEAANLIDSR ADERDQPFLL GATNLKIPSY KACFLALVRC FYELGVKELH 300
    GHLLYALGDG EYAAASAWLD RQGILAQVSG TVNAWQENGK QSIDDLFEQV 350
    EYRLLAAWEK DAGLMTYGEA VEEMLQFGES EGELIGMSPE EWRRFVGRAS 400
    LYAAREKAKE LGVDPGWDCE LAKTPEGYYQ IRGGIQYAIA KSLAAAPFAD 450
    ILWMETKTAD LADARQFAEA IHAEFPEQML AYNLSPSFNW DTTGMSDEEM 500
    KRFPEELGKM GFVFNFITYG GHQIDGVAAE EFATALRQDG MLALARLQRK 550
    MRLVESPYRT PQTLVGGPVA MQRWLRPPDV RRQPRPWAKV RPSTSILCRP 600
    RCRRSC 606
    Length:606
    Mass (Da):67,601
    Last modified:April 27, 2001 - v2
    Checksum:iD82CCCADD6B6D384
    GO

    Sequence cautioni

    The sequence CAC30940.1 differs from that shown. Reason: Frameshift at position 569.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581R → L in CAA86357. (PubMed:7476188)Curated
    Sequence conflicti569 – 5691V → L in CAA86357. (PubMed:7476188)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46257 Genomic DNA. Translation: CAA86357.1.
    AL583924 Genomic DNA. Translation: CAC30940.1. Frameshift.
    PIRiD87157.
    S77654.
    RefSeqiNP_302337.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30940; CAC30940; CAC30940.
    GeneIDi909102.
    KEGGimle:ML1985.
    PATRICi18057640. VBIMycLep78757_3744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46257 Genomic DNA. Translation: CAA86357.1 .
    AL583924 Genomic DNA. Translation: CAC30940.1 . Frameshift.
    PIRi D87157.
    S77654.
    RefSeqi NP_302337.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P46831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1985.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30940 ; CAC30940 ; CAC30940 .
    GeneIDi 909102.
    KEGGi mle:ML1985.
    PATRICi 18057640. VBIMycLep78757_3744.

    Organism-specific databases

    Lepromai ML1985.

    Phylogenomic databases

    eggNOGi COG2224.
    HOGENOMi HOG000238475.
    KOi K01637.
    OrthoDBi EOG689HMX.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 2 hits.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Mycobacterium leprae genome: systematic sequence analysis identifies key catabolic enzymes, ATP-dependent transport systems and a novel polA locus associated with genomic variability."
      Fsihi H., Cole S.T.
      Mol. Microbiol. 16:909-919(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiACEA_MYCLE
    AccessioniPrimary (citable) accession number: P46831
    Secondary accession number(s): Q9CBH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3