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P46831

- ACEA_MYCLE

UniProt

P46831 - ACEA_MYCLE

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Protein

Isocitrate lyase

Gene

aceA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Cofactori

Divalent cations.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:aceA
Ordered Locus Names:ML1985
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1985.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606Isocitrate lyasePRO_0000068778Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1985.

Structurei

3D structure databases

ProteinModelPortaliP46831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000238475.
KOiK01637.
OrthoDBiEOG689HMX.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 2 hits.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 2 hits.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46831-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIMDTNTEV HTLFTQEVAA TQQYFDDPRF AGIIRLYTAR QVVEQRGTIP
60 70 80 90 100
TDYTVARDAA TAFYARLREL FAAGKSVTTF GPYSPGQAVS LKRMGIEAIY
110 120 130 140 150
LGGWATSAKG SITEDPGPDL ASYPLSQVPD DAAVLVRALL AADRNQQYLR
160 170 180 190 200
LHMTEQQRAA TPAYDYRPFI IADADTGHGG DSHVRNLIRR FVEIGVPGYH
210 220 230 240 250
IEDQRPGTKK CGHQGGKVLV PSDEQIKRLN AARFQLDIMR VPGIIVARTD
260 270 280 290 300
AEAANLIDSR ADERDQPFLL GATNLKIPSY KACFLALVRC FYELGVKELH
310 320 330 340 350
GHLLYALGDG EYAAASAWLD RQGILAQVSG TVNAWQENGK QSIDDLFEQV
360 370 380 390 400
EYRLLAAWEK DAGLMTYGEA VEEMLQFGES EGELIGMSPE EWRRFVGRAS
410 420 430 440 450
LYAAREKAKE LGVDPGWDCE LAKTPEGYYQ IRGGIQYAIA KSLAAAPFAD
460 470 480 490 500
ILWMETKTAD LADARQFAEA IHAEFPEQML AYNLSPSFNW DTTGMSDEEM
510 520 530 540 550
KRFPEELGKM GFVFNFITYG GHQIDGVAAE EFATALRQDG MLALARLQRK
560 570 580 590 600
MRLVESPYRT PQTLVGGPVA MQRWLRPPDV RRQPRPWAKV RPSTSILCRP

RCRRSC
Length:606
Mass (Da):67,601
Last modified:April 27, 2001 - v2
Checksum:iD82CCCADD6B6D384
GO

Sequence cautioni

The sequence CAC30940.1 differs from that shown. Reason: Frameshift at position 569.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581R → L in CAA86357. (PubMed:7476188)Curated
Sequence conflicti569 – 5691V → L in CAA86357. (PubMed:7476188)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46257 Genomic DNA. Translation: CAA86357.1.
AL583924 Genomic DNA. Translation: CAC30940.1. Frameshift.
PIRiD87157.
S77654.
RefSeqiNP_302337.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30940; CAC30940; CAC30940.
GeneIDi909102.
KEGGimle:ML1985.
PATRICi18057640. VBIMycLep78757_3744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46257 Genomic DNA. Translation: CAA86357.1 .
AL583924 Genomic DNA. Translation: CAC30940.1 . Frameshift.
PIRi D87157.
S77654.
RefSeqi NP_302337.1. NC_002677.1.

3D structure databases

ProteinModelPortali P46831.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30940 ; CAC30940 ; CAC30940 .
GeneIDi 909102.
KEGGi mle:ML1985.
PATRICi 18057640. VBIMycLep78757_3744.

Organism-specific databases

Lepromai ML1985.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000238475.
KOi K01637.
OrthoDBi EOG689HMX.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 2 hits.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 2 hits.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Mycobacterium leprae genome: systematic sequence analysis identifies key catabolic enzymes, ATP-dependent transport systems and a novel polA locus associated with genomic variability."
    Fsihi H., Cole S.T.
    Mol. Microbiol. 16:909-919(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiACEA_MYCLE
AccessioniPrimary (citable) accession number: P46831
Secondary accession number(s): Q9CBH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3