Reviewed, UniProtKB/Swiss-Prot P46829 (DAPB2_MYCBO)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:

dapB

Organism

Mycobacterium bovis

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Dihydrodipicolinate reductase		PRO_0000141457

Sequences

	Sequence		Length	Mass (Da)
	P46829-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 16DE4B090E481F6F	FASTA	271	27,679
	10 20 30 40 50 60 MTTRVALVGG TGKLGAIIAG VIDELDDFET VAVLGSDERS REIDAADLVV DASTPGVSID 70 80 90 100 110 120 VVRAAIERGK NVLVGTSGWS TERIALVRPL VEAAGTGAVF IPNFSLGSVV ATALAAAAAP 130 140 150 160 170 180 LFPSIEIVET HRETKVDSPS GTAVRTAELI ADARVGVGPV ESPHVDQRAR GQQVASVPIH 190 200 210 220 230 240 SLRRPGVIAN EETILSGPGE SLTIVHDTIE PARAYAPGIR IALAARADAR GVTIGLDALI 250 260 270 DLGLAPRPAA PVIEVVDEGS VPGQVARVTG A

References

[1]	"Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria." Cirillo J.D., Weisbrod T.R., Banerjee A., Bloom B.R., Jacobs W.R. Jr. J. Bacteriol. 176:4424-4429(1994) [PubMed: 8021227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BCG / Pasteur.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L24366 Genomic DNA. Translation: AAA21562.1.
PIR	A55517.
3D structure databases
ModBase	Search...
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB2_MYCBO

Accession

Primary (citable) accession number: P46829

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)