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Protein

Catabolite control protein A

Gene

ccpA

Organism
Bacillus megaterium
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 2420H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catabolite control protein A
Alternative name(s):
Catabolite control protein
Glucose-resistance amylase regulator
Gene namesi
Name:ccpA
OrganismiBacillus megaterium
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Catabolite control protein APRO_0000107924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi545693.BMQ_4818.

Structurei

Secondary structure

1
332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 117Combined sources
Helixi16 – 238Combined sources
Helixi31 – 4414Combined sources
Helixi50 – 556Combined sources
Beta strandi62 – 676Combined sources
Beta strandi70 – 723Combined sources
Helixi74 – 8916Combined sources
Beta strandi92 – 976Combined sources
Helixi101 – 11111Combined sources
Turni114 – 1163Combined sources
Beta strandi120 – 1223Combined sources
Helixi129 – 1357Combined sources
Beta strandi138 – 1403Combined sources
Beta strandi142 – 1465Combined sources
Beta strandi156 – 1594Combined sources
Helixi161 – 17313Combined sources
Turni174 – 1763Combined sources
Beta strandi180 – 1856Combined sources
Beta strandi187 – 1893Combined sources
Helixi190 – 1934Combined sources
Helixi196 – 20510Combined sources
Turni206 – 2083Combined sources
Helixi213 – 2153Combined sources
Beta strandi216 – 2183Combined sources
Helixi223 – 23513Combined sources
Beta strandi236 – 2383Combined sources
Beta strandi241 – 2477Combined sources
Helixi248 – 26013Combined sources
Helixi265 – 2684Combined sources
Beta strandi270 – 2756Combined sources
Helixi278 – 2814Combined sources
Beta strandi282 – 2854Combined sources
Beta strandi288 – 2914Combined sources
Helixi294 – 30916Combined sources
Beta strandi319 – 3213Combined sources
Beta strandi324 – 3263Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RZRX-ray2.80A/C/D/G1-332[»]
1SXGX-ray2.75A/B/D/F/I/P53-332[»]
1SXHX-ray2.75A/D53-332[»]
1SXIX-ray3.00A/B/D/G/I/K/L/M/N/R/T/W53-332[»]
2HSGX-ray2.50A1-332[»]
2JCGX-ray2.60A1-332[»]
2NZUX-ray2.50G53-332[»]
2NZVX-ray3.00G53-332[»]
2OENX-ray3.17G53-332[»]
ProteinModelPortaliP46828.
SMRiP46828. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46828.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757HTH lacI-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTIYDVAR EASVSMATVS RVVNGNPNVK PSTRKKVLET IERLGYRPNA
60 70 80 90 100
VARGLASKKT TTVGVIIPDI SNIFYAELAR GIEDIATMYK YNIILSNSDQ
110 120 130 140 150
NQDKELHLLN NMLGKQVDGI IFMSGNVTEE HVEELKKSPV PVVLAASIES
160 170 180 190 200
TNQIPSVTID YEQAAFDAVQ SLIDSGHKNI AFVSGTLEEP INHAKKVKGY
210 220 230 240 250
KRALTESGLP VRDSYIVEGD YTYDSGIEAV EKLLEEDEKP TAIFVGTDEM
260 270 280 290 300
ALGVIHGAQD RGLNVPNDLE IIGFDNTRLS TMVRPQLTSV VQPMYDIGAV
310 320 330
AMRLLTKYMN KETVDSSIVQ LPHRIEFRQS TK
Length:332
Mass (Da):36,645
Last modified:November 1, 1995 - v1
Checksum:iFED354B07E86A136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26052 Genomic DNA. Translation: AAA22295.1.
PIRiI39800.

Genome annotation databases

GeneIDi9120195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26052 Genomic DNA. Translation: AAA22295.1.
PIRiI39800.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RZRX-ray2.80A/C/D/G1-332[»]
1SXGX-ray2.75A/B/D/F/I/P53-332[»]
1SXHX-ray2.75A/D53-332[»]
1SXIX-ray3.00A/B/D/G/I/K/L/M/N/R/T/W53-332[»]
2HSGX-ray2.50A1-332[»]
2JCGX-ray2.60A1-332[»]
2NZUX-ray2.50G53-332[»]
2NZVX-ray3.00G53-332[»]
2OENX-ray3.17G53-332[»]
ProteinModelPortaliP46828.
SMRiP46828. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi545693.BMQ_4818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9120195.

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.

Miscellaneous databases

EvolutionaryTraceiP46828.
PROiP46828.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences of ccpA and two downstream Bacillus megaterium genes with homology to the motAB operon from Bacillus subtilis."
    Hueck C., Kraus A., Hillen W.
    Gene 143:147-148(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCPA_BACME
AccessioniPrimary (citable) accession number: P46828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.