Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catabolite control protein A

Gene

ccpA

Organism
Bacillus megaterium
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catabolite control protein A
Alternative name(s):
Catabolite control protein
Glucose-resistance amylase regulator
Gene namesi
Name:ccpA
OrganismiBacillus megaterium
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079241 – 332Catabolite control protein AAdd BLAST332

Interactioni

Protein-protein interaction databases

STRINGi545693.BMQ_4818.

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 11Combined sources7
Helixi16 – 23Combined sources8
Helixi31 – 44Combined sources14
Helixi50 – 55Combined sources6
Beta strandi62 – 67Combined sources6
Beta strandi70 – 72Combined sources3
Helixi74 – 89Combined sources16
Beta strandi92 – 97Combined sources6
Helixi101 – 111Combined sources11
Turni114 – 116Combined sources3
Beta strandi120 – 122Combined sources3
Helixi129 – 135Combined sources7
Beta strandi138 – 140Combined sources3
Beta strandi142 – 146Combined sources5
Beta strandi156 – 159Combined sources4
Helixi161 – 173Combined sources13
Turni174 – 176Combined sources3
Beta strandi180 – 185Combined sources6
Beta strandi187 – 189Combined sources3
Helixi190 – 193Combined sources4
Helixi196 – 205Combined sources10
Turni206 – 208Combined sources3
Helixi213 – 215Combined sources3
Beta strandi216 – 218Combined sources3
Helixi223 – 235Combined sources13
Beta strandi236 – 238Combined sources3
Beta strandi241 – 247Combined sources7
Helixi248 – 260Combined sources13
Helixi265 – 268Combined sources4
Beta strandi270 – 275Combined sources6
Helixi278 – 281Combined sources4
Beta strandi282 – 285Combined sources4
Beta strandi288 – 291Combined sources4
Helixi294 – 309Combined sources16
Beta strandi319 – 321Combined sources3
Beta strandi324 – 326Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RZRX-ray2.80A/C/D/G1-332[»]
1SXGX-ray2.75A/B/D/F/I/P53-332[»]
1SXHX-ray2.75A/D53-332[»]
1SXIX-ray3.00A/B/D/G/I/K/L/M/N/R/T/W53-332[»]
2HSGX-ray2.50A1-332[»]
2JCGX-ray2.60A1-332[»]
2NZUX-ray2.50G53-332[»]
2NZVX-ray3.00G53-332[»]
2OENX-ray3.17G53-332[»]
ProteinModelPortaliP46828.
SMRiP46828.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46828.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57HTH lacI-typePROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTIYDVAR EASVSMATVS RVVNGNPNVK PSTRKKVLET IERLGYRPNA
60 70 80 90 100
VARGLASKKT TTVGVIIPDI SNIFYAELAR GIEDIATMYK YNIILSNSDQ
110 120 130 140 150
NQDKELHLLN NMLGKQVDGI IFMSGNVTEE HVEELKKSPV PVVLAASIES
160 170 180 190 200
TNQIPSVTID YEQAAFDAVQ SLIDSGHKNI AFVSGTLEEP INHAKKVKGY
210 220 230 240 250
KRALTESGLP VRDSYIVEGD YTYDSGIEAV EKLLEEDEKP TAIFVGTDEM
260 270 280 290 300
ALGVIHGAQD RGLNVPNDLE IIGFDNTRLS TMVRPQLTSV VQPMYDIGAV
310 320 330
AMRLLTKYMN KETVDSSIVQ LPHRIEFRQS TK
Length:332
Mass (Da):36,645
Last modified:November 1, 1995 - v1
Checksum:iFED354B07E86A136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26052 Genomic DNA. Translation: AAA22295.1.
PIRiI39800.

Genome annotation databases

GeneIDi9120195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26052 Genomic DNA. Translation: AAA22295.1.
PIRiI39800.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RZRX-ray2.80A/C/D/G1-332[»]
1SXGX-ray2.75A/B/D/F/I/P53-332[»]
1SXHX-ray2.75A/D53-332[»]
1SXIX-ray3.00A/B/D/G/I/K/L/M/N/R/T/W53-332[»]
2HSGX-ray2.50A1-332[»]
2JCGX-ray2.60A1-332[»]
2NZUX-ray2.50G53-332[»]
2NZVX-ray3.00G53-332[»]
2OENX-ray3.17G53-332[»]
ProteinModelPortaliP46828.
SMRiP46828.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi545693.BMQ_4818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9120195.

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.

Miscellaneous databases

EvolutionaryTraceiP46828.
PROiP46828.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCPA_BACME
AccessioniPrimary (citable) accession number: P46828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.