P46813 (SUHB_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol-1-monophosphatase
Short name=I-1-Pase
Short name=IMPase
Short name=Inositol-1-phosphatase
EC=3.1.3.25

Gene names

Name:	suhB
Synonyms:	ssyA
Ordered Locus Names:	ML1024

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	inositol monophosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Inositol-1-monophosphatase		PRO_0000142563
Regions
	Region	106 – 109	4	Substrate binding By similarity
Sites
	Metal binding	83	1	Magnesium 1 By similarity
	Metal binding	104	1	Magnesium 1 By similarity
	Metal binding	104	1	Magnesium 2 By similarity
	Metal binding	106	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	107	1	Magnesium 2 By similarity
	Metal binding	235	1	Magnesium 2 By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	206	1	Substrate By similarity
	Binding site	235	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46813 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 6889A717AED6EC5D	FASTA	291	29,687
	10 20 30 40 50 60 MTVPDNDPEQ LRCVAESLAT EAAAFVRCRR AEVFGTDLGA AGGGAVRAKS TPTDPVTVVD 70 80 90 100 110 120 TETERLLRDR LAQLRPGDSI LGEEGGGPAD LTATPADTVT WVLDPIDGTV NFVYGIPAYA 130 140 150 160 170 180 VSVAAQVDGV SVAGAVAEVV AGRVHSAASG LGAHVTDEYG VQVLRCSAVD DLSMALLGTG 190 200 210 220 230 240 FAYSVVRRAA QAALLAQMLP VVRDVRRIGS AALDLCMVAA GQLDAYYEHE VQVWDCAAGA 250 260 270 280 290 LIAAEAGACV QLPKRNGPVG GAGLVVAAAP GIADALLAAL QRFNGLAPIL D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15181 Genomic DNA. Translation: AAA62956.1. AL583920 Genomic DNA. Translation: CAC31405.1.
PIR	B87037.
RefSeq	NP_301757.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P46813.
SMR	P46813. Positions 5-286.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029171; EBMYCP00000028777; EBMYCG00000029166.
GeneID	910084.
GenomeReviews	Gene locus ML1024 in contig AL450380_GR.
KEGG	mle:ML1024.
NMPDR	fig|272631.1.peg.629.
PATRIC	18053816. VBIMycLep78757_1853.
Organism-specific databases
Leproma	ML1024.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015694.
HOGENOM	HBG730251.
OMA	VNFIVQK.
ProtClustDB	CLSK792016.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1024-MONOMER.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
KO	K01092.
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUHB_MYCLE

Accession

Primary (citable) accession number: P46813

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program