Reviewed,
UniProtKB/Swiss-Prot P46806 (DHOM_MYCLE)
Last modified
July 22, 2008.
Version 54.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Homoserine dehydrogenase Short name=HDH EC=1.1.1.3 | ||||
| Gene names |
| ||||
| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1769 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 441 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 441 | 441 | Homoserine dehydrogenase | |||||
Regions | ||||||||
| Domain | 355 – 433 | 79 | ACT | |||||
| Nucleotide binding | 13 – 20 | 8 | NADP By similarity | |||||
Sites | ||||||||
| Active site | 207 | 1 | Proton donor Potential | |||||
| Binding site | 107 | 1 | NADP By similarity | |||||
| Binding site | 192 | 1 | Substrate By similarity | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Smith D.R., Robison K. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
Cross-references
Sequence databases | |
|---|---|
| U15186 Genomic DNA. Translation: AAA63101.1. AL583920 Genomic DNA. Translation: CAC31510.1. | |
| PIR | T09992. |
| RefSeq | NP_301823.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 910223. |
| GenomeReviews | Gene locus ML1129 in contig AL450380_GR. |
| KEGG | mle:ML1129. |
| NMPDR | fig|272631.1.peg.695. |
Organism-specific databases | |
| Leproma | ML1129. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P46806. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML1129-MON. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR005106. Asp/hSer_DHase_NAD-bd. IPR016204. hSer_DHase. IPR001342. hSer_DHase_cat. [Graphical view] |
| Pfam | PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF000098. Homoser_dehydrog. 1 hit. |
| PROSITE | PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProDom | P46806. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | DHOM_MYCLE | ||||||||
| Accession | Primary (citable) accession number: P46806 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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