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P46806 (DHOM_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine dehydrogenase

Short name=HDH
EC=1.1.1.3
Gene names
Name:hom
Ordered Locus Names:ML1129
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Homoserine dehydrogenase
PRO_0000066701

Regions

Domain355 – 43379ACT
Nucleotide binding13 – 208NADP By similarity

Sites

Active site2071Proton donor Potential
Binding site1071NADP By similarity
Binding site1921Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P46806 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 41EEC1939A5FD0F8

FASTA44145,606
        10         20         30         40         50         60 
MFSDERTVGV AVLGLGNVGS EVVRIIEGSA DDLAARIGAP LMLRGIGVRR VAVDRGVPVD 

        70         80         90        100        110        120 
LLTDNIEELV SRADVDIVVE VMGPVELSRK AILSALEHGK SVVTANKALL AASTGELAQA 

       130        140        150        160        170        180 
AESAHVDLYF EAAVAGAIPV IRPLTQSLAG DTVLRVAGIV NGTTNYILSA MDSTGADYDS 

       190        200        210        220        230        240 
ALAGARALGY AEADPTADVE GHDAAAKAAI LASIAFHTRV TADDVYREGI TKITPADFVS 

       250        260        270        280        290        300 
ARALGCTIKL LFICERITAA DGQQRVSARV YPALVPMSHP LATVSGAFNA VVVEAEAAGR 

       310        320        330        340        350        360 
LMFYGQGAGG APTASAVTGD LVMAARNRVL GSRGPKESKY AQLPMETIGF ISTRYYVSMN 

       370        380        390        400        410        420 
VADKPGVLSG VAAEFAKREV SIAEVRQEGV VDDGGRRVGA RIVVVTHGAT DAALSETVDA 

       430        440 
LADLDVVQGV TSVLRLEGIS L 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15186 Genomic DNA. Translation: AAA63101.1.
AL583920 Genomic DNA. Translation: CAC31510.1.
PIRT09992.
RefSeqNP_301823.1. NC_002677.1.

3D structure databases

ProteinModelPortalP46806.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028455; EBMYCP00000028061; EBMYCG00000028450.
GeneID910223.
GenomeReviewsGene locus ML1129 in contig AL450380_GR.
KEGGmle:ML1129.
NMPDRfig|272631.1.peg.695.
PATRIC18054213. VBIMycLep78757_2051.

Organism-specific databases

LepromaML1129.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016352.
HOGENOMHBG527379.
OMAVHPAMIP.
ProtClustDBPRK06349.

Enzyme and pathway databases

BioCycMLEP272631:ML1129-MONOMER.

Family and domain databases

InterProIPR002912. ACT-bd.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00003.
PfamPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF000098. Homoser_dehydrog. 1 hit.
PROSITEPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHOM_MYCLE
AccessionPrimary (citable) accession number: P46806
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families