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Protein

Homoserine dehydrogenase

Gene

hom

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (ask)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (ask)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107NADPBy similarity1
Binding sitei192SubstrateBy similarity1
Active sitei207Proton donorSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenase (EC:1.1.1.3)
Short name:
HDH
Gene namesi
Name:hom
Ordered Locus Names:ML1129
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000667011 – 441Homoserine dehydrogenaseAdd BLAST441

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1129.

Structurei

3D structure databases

ProteinModelPortaliP46806.
SMRiP46806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 435ACTPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105D6E. Bacteria.
COG0460. LUCA.
HOGENOMiHOG000076615.
KOiK00003.
OMAiEWIAGII.
OrthoDBiPOG091H01V3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSDERTVGV AVLGLGNVGS EVVRIIEGSA DDLAARIGAP LMLRGIGVRR
60 70 80 90 100
VAVDRGVPVD LLTDNIEELV SRADVDIVVE VMGPVELSRK AILSALEHGK
110 120 130 140 150
SVVTANKALL AASTGELAQA AESAHVDLYF EAAVAGAIPV IRPLTQSLAG
160 170 180 190 200
DTVLRVAGIV NGTTNYILSA MDSTGADYDS ALAGARALGY AEADPTADVE
210 220 230 240 250
GHDAAAKAAI LASIAFHTRV TADDVYREGI TKITPADFVS ARALGCTIKL
260 270 280 290 300
LFICERITAA DGQQRVSARV YPALVPMSHP LATVSGAFNA VVVEAEAAGR
310 320 330 340 350
LMFYGQGAGG APTASAVTGD LVMAARNRVL GSRGPKESKY AQLPMETIGF
360 370 380 390 400
ISTRYYVSMN VADKPGVLSG VAAEFAKREV SIAEVRQEGV VDDGGRRVGA
410 420 430 440
RIVVVTHGAT DAALSETVDA LADLDVVQGV TSVLRLEGIS L
Length:441
Mass (Da):45,606
Last modified:November 1, 1995 - v1
Checksum:i41EEC1939A5FD0F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63101.1.
AL583920 Genomic DNA. Translation: CAC31510.1.
PIRiT09992.
RefSeqiNP_301823.1. NC_002677.1.
WP_010908147.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31510; CAC31510; CAC31510.
GeneIDi910223.
KEGGimle:ML1129.
PATRICi18054213. VBIMycLep78757_2051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63101.1.
AL583920 Genomic DNA. Translation: CAC31510.1.
PIRiT09992.
RefSeqiNP_301823.1. NC_002677.1.
WP_010908147.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46806.
SMRiP46806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31510; CAC31510; CAC31510.
GeneIDi910223.
KEGGimle:ML1129.
PATRICi18054213. VBIMycLep78757_2051.

Organism-specific databases

LepromaiML1129.

Phylogenomic databases

eggNOGiENOG4105D6E. Bacteria.
COG0460. LUCA.
HOGENOMiHOG000076615.
KOiK00003.
OMAiEWIAGII.
OrthoDBiPOG091H01V3.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHOM_MYCLE
AccessioniPrimary (citable) accession number: P46806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.