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P46804

- SPD2_NEPCL

UniProt

P46804 - SPD2_NEPCL

Protein

Spidroin-2

Gene
N/A
Organism
Nephila clavipes (Golden silk orbweaver)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Spiders' major ampullate silk possesses unique characteristics of strength and elasticity. Fibroin consists of pseudocrystalline regions of antiparallel beta-sheet interspersed with elastic amorphous segments.

    Keywords - Molecular functioni

    Silk protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spidroin-2
    Alternative name(s):
    Dragline silk fibroin 2
    OrganismiNephila clavipes (Golden silk orbweaver)
    Taxonomic identifieri6915 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaNephilidaeNephila

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 627›627Spidroin-2PRO_0000221447Add
    BLAST

    Interactioni

    Subunit structurei

    Major subunit, with spidroin 1, of the dragline silk.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 36361Add
    BLAST
    Repeati37 – 79432Add
    BLAST
    Repeati80 – 121423Add
    BLAST
    Repeati122 – 172514Add
    BLAST
    Repeati173 – 213415Add
    BLAST
    Repeati214 – 252396Add
    BLAST
    Repeati253 – 283317Add
    BLAST
    Repeati284 – 317348Add
    BLAST
    Repeati318 – 359429Add
    BLAST
    Repeati360 – 3913210Add
    BLAST
    Repeati392 – 4283711Add
    BLAST
    Repeati429 – 4643612Add
    BLAST
    Repeati465 – 4882413Add
    BLAST
    Repeati489 – 5152714Add
    BLAST
    Repeati516 – 5301515Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 53053015 X approximate tandem repeatsAdd
    BLAST

    Domaini

    Highly repetitive protein characterized by regions of polyalanine and glycine-rich repeating units.

    Sequence similaritiesi

    Belongs to the silk fibroin family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR021001. Spidroin_C.
    [Graphical view]
    PfamiPF11260. Spidroin_MaSp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P46804-1 [UniParc]FASTAAdd to Basket

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    PGGYGPGQQG PGGYGPGQQG PSGPGSAAAA AAAAAAGPGG YGPGQQGPGG    50
    YGPGQQGPGR YGPGQQGPSG PGSAAAAAAG SGQQGPGGYG PRQQGPGGYG 100
    QGQQGPSGPG SAAAASAAAS AESGQQGPGG YGPGQQGPGG YGPGQQGPGG 150
    YGPGQQGPSG PGSAAAAAAA ASGPGQQGPG GYGPGQQGPG GYGPGQQGPS 200
    GPGSAAAAAA AASGPGQQGP GGYGPGQQGP GGYGPGQQGL SGPGSAAAAA 250
    AAGPGQQGPG GYGPGQQGPS GPGSAAAAAA AAAGPGGYGP GQQGPGGYGP 300
    GQQGPSGAGS AAAAAAAGPG QQGLGGYGPG QQGPGGYGPG QQGPGGYGPG 350
    SASAAAAAAG PGQQGPGGYG PGQQGPSGPG SASAAAAAAA AGPGGYGPGQ 400
    QGPGGYAPGQ QGPSGPGSAS AAAAAAAAGP GGYGPGQQGP GGYAPGQQGP 450
    SGPGSAAAAA AAAAGPGGYG PAQQGPSGPG IAASAASAGP GGYGPAQQGP 500
    AGYGPGSAVA ASAGAGSAGY GPGSQASAAA SRLASPDSGA RVASAVSNLV 550
    SSGPTSSAAL SSVISNAVSQ IGASNPGLSG CDVLIQALLE IVSACVTILS 600
    SSSIGQVNYG AASQFAQVVG QSVLSAF 627
    Length:627
    Mass (Da):54,184
    Last modified:November 1, 1995 - v1
    Checksum:iCB9B63779B2C594B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92913 mRNA. Translation: AAA29381.1.
    PIRiA44112.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The tiptoe of an airbus - Issue 24 of July 2002

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92913 mRNA. Translation: AAA29381.1 .
    PIRi A44112.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR021001. Spidroin_C.
    [Graphical view ]
    Pfami PF11260. Spidroin_MaSp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber."
      Hinman M.B., Lewis R.V.
      J. Biol. Chem. 267:19320-19324(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSPD2_NEPCL
    AccessioniPrimary (citable) accession number: P46804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3