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P46804

- SPD2_NEPCL

UniProt

P46804 - SPD2_NEPCL

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Protein

Spidroin-2

Gene
N/A
Organism
Nephila clavipes (Golden silk orbweaver)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Spiders' major ampullate silk possesses unique characteristics of strength and elasticity. Fibroin consists of pseudocrystalline regions of antiparallel beta-sheet interspersed with elastic amorphous segments.

Keywords - Molecular functioni

Silk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Spidroin-2
Alternative name(s):
Dragline silk fibroin 2
OrganismiNephila clavipes (Golden silk orbweaver)
Taxonomic identifieri6915 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaNephilidaeNephila

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 627›627Spidroin-2PRO_0000221447Add
BLAST

Interactioni

Subunit structurei

Major subunit, with spidroin 1, of the dragline silk.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 36361Add
BLAST
Repeati37 – 79432Add
BLAST
Repeati80 – 121423Add
BLAST
Repeati122 – 172514Add
BLAST
Repeati173 – 213415Add
BLAST
Repeati214 – 252396Add
BLAST
Repeati253 – 283317Add
BLAST
Repeati284 – 317348Add
BLAST
Repeati318 – 359429Add
BLAST
Repeati360 – 3913210Add
BLAST
Repeati392 – 4283711Add
BLAST
Repeati429 – 4643612Add
BLAST
Repeati465 – 4882413Add
BLAST
Repeati489 – 5152714Add
BLAST
Repeati516 – 5301515Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 53053015 X approximate tandem repeatsAdd
BLAST

Domaini

Highly repetitive protein characterized by regions of polyalanine and glycine-rich repeating units.

Sequence similaritiesi

Belongs to the silk fibroin family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR021001. Spidroin_C.
[Graphical view]
PfamiPF11260. Spidroin_MaSp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P46804-1 [UniParc]FASTAAdd to Basket

« Hide

PGGYGPGQQG PGGYGPGQQG PSGPGSAAAA AAAAAAGPGG YGPGQQGPGG    50
YGPGQQGPGR YGPGQQGPSG PGSAAAAAAG SGQQGPGGYG PRQQGPGGYG 100
QGQQGPSGPG SAAAASAAAS AESGQQGPGG YGPGQQGPGG YGPGQQGPGG 150
YGPGQQGPSG PGSAAAAAAA ASGPGQQGPG GYGPGQQGPG GYGPGQQGPS 200
GPGSAAAAAA AASGPGQQGP GGYGPGQQGP GGYGPGQQGL SGPGSAAAAA 250
AAGPGQQGPG GYGPGQQGPS GPGSAAAAAA AAAGPGGYGP GQQGPGGYGP 300
GQQGPSGAGS AAAAAAAGPG QQGLGGYGPG QQGPGGYGPG QQGPGGYGPG 350
SASAAAAAAG PGQQGPGGYG PGQQGPSGPG SASAAAAAAA AGPGGYGPGQ 400
QGPGGYAPGQ QGPSGPGSAS AAAAAAAAGP GGYGPGQQGP GGYAPGQQGP 450
SGPGSAAAAA AAAAGPGGYG PAQQGPSGPG IAASAASAGP GGYGPAQQGP 500
AGYGPGSAVA ASAGAGSAGY GPGSQASAAA SRLASPDSGA RVASAVSNLV 550
SSGPTSSAAL SSVISNAVSQ IGASNPGLSG CDVLIQALLE IVSACVTILS 600
SSSIGQVNYG AASQFAQVVG QSVLSAF 627
Length:627
Mass (Da):54,184
Last modified:November 1, 1995 - v1
Checksum:iCB9B63779B2C594B
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92913 mRNA. Translation: AAA29381.1.
PIRiA44112.

Cross-referencesi

Web resourcesi

Protein Spotlight

The tiptoe of an airbus - Issue 24 of July 2002

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92913 mRNA. Translation: AAA29381.1 .
PIRi A44112.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021001. Spidroin_C.
[Graphical view ]
Pfami PF11260. Spidroin_MaSp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber."
    Hinman M.B., Lewis R.V.
    J. Biol. Chem. 267:19320-19324(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSPD2_NEPCL
AccessioniPrimary (citable) accession number: P46804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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