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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 144ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:TM_0926
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142861 – 440Chromosomal replication initiator protein DnaAAdd BLAST440

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0926

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi104 – 106Combined sources3
Turni111 – 113Combined sources3
Helixi114 – 125Combined sources12
Turni127 – 129Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi138 – 142Combined sources5
Helixi143 – 157Combined sources15
Beta strandi158 – 161Combined sources4
Beta strandi163 – 167Combined sources5
Helixi168 – 180Combined sources13
Helixi184 – 191Combined sources8
Turni192 – 194Combined sources3
Beta strandi196 – 201Combined sources6
Helixi203 – 206Combined sources4
Helixi210 – 224Combined sources15
Turni225 – 227Combined sources3
Beta strandi229 – 236Combined sources8
Helixi238 – 240Combined sources3
Helixi246 – 253Combined sources8
Beta strandi254 – 256Combined sources3
Helixi265 – 279Combined sources15
Helixi287 – 294Combined sources8
Helixi299 – 315Combined sources17
Beta strandi316 – 318Combined sources3
Helixi322 – 328Combined sources7
Turni331 – 333Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z4RX-ray3.05A/B/C1-440[»]
2Z4SX-ray3.00A1-440[»]
ProteinModelPortaliP46798
SMRiP46798
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46798

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
InParanoidiP46798
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

P46798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERILQEIK TRVNRKSWEL WFSSFDVKSI EGNKVVFSVG NLFIKEWLEK
60 70 80 90 100
KYYSVLSKAV KVVLGNDATF EITYEAFEPH SSYSEPLVKK RAVLLTPLNP
110 120 130 140 150
DYTFENFVVG PGNSFAYHAA LEVAKHPGRY NPLFIYGGVG LGKTHLLQSI
160 170 180 190 200
GNYVVQNEPD LRVMYITSEK FLNDLVDSMK EGKLNEFREK YRKKVDILLI
210 220 230 240 250
DDVQFLIGKT GVQTELFHTF NELHDSGKQI VICSDREPQK LSEFQDRLVS
260 270 280 290 300
RFQMGLVAKL EPPDEETRKS IARKMLEIEH GELPEEVLNF VAENVDDNLR
310 320 330 340 350
RLRGAIIKLL VYKETTGKEV DLKEAILLLK DFIKPNRVKA MDPIDELIEI
360 370 380 390 400
VAKVTGVPRE EILSNSRNVK ALTARRIGMY VAKNYLKSSL RTIAEKFNRS
410 420 430 440
HPVVVDSVKK VKDSLLKGNK QLKALIDEVI GEISRRALSG
Length:440
Mass (Da):50,304
Last modified:November 1, 1995 - v1
Checksum:i2E35ED82650A5C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24145 Genomic DNA Translation: AAA65438.1
AE000512 Genomic DNA Translation: AAD36007.1
PIRiG72317
RefSeqiNP_228734.1, NC_000853.1
WP_004080636.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD36007; AAD36007; TM_0926
GeneIDi898600
KEGGitma:TM0926

Similar proteinsi

Entry informationi

Entry nameiDNAA_THEMA
AccessioniPrimary (citable) accession number: P46798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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