Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 144ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:TM_0926
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142861 – 440Chromosomal replication initiator protein DnaAAdd BLAST440

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0926.

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi104 – 106Combined sources3
Turni111 – 113Combined sources3
Helixi114 – 125Combined sources12
Turni127 – 129Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi138 – 142Combined sources5
Helixi143 – 157Combined sources15
Beta strandi158 – 161Combined sources4
Beta strandi163 – 167Combined sources5
Helixi168 – 180Combined sources13
Helixi184 – 191Combined sources8
Turni192 – 194Combined sources3
Beta strandi196 – 201Combined sources6
Helixi203 – 206Combined sources4
Helixi210 – 224Combined sources15
Turni225 – 227Combined sources3
Beta strandi229 – 236Combined sources8
Helixi238 – 240Combined sources3
Helixi246 – 253Combined sources8
Beta strandi254 – 256Combined sources3
Helixi265 – 279Combined sources15
Helixi287 – 294Combined sources8
Helixi299 – 315Combined sources17
Beta strandi316 – 318Combined sources3
Helixi322 – 328Combined sources7
Turni331 – 333Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z4RX-ray3.05A/B/C1-440[»]
2Z4SX-ray3.00A1-440[»]
ProteinModelPortaliP46798.
SMRiP46798.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46798.

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiP46798.
KOiK02313.
OMAiQSKTRKR.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERILQEIK TRVNRKSWEL WFSSFDVKSI EGNKVVFSVG NLFIKEWLEK
60 70 80 90 100
KYYSVLSKAV KVVLGNDATF EITYEAFEPH SSYSEPLVKK RAVLLTPLNP
110 120 130 140 150
DYTFENFVVG PGNSFAYHAA LEVAKHPGRY NPLFIYGGVG LGKTHLLQSI
160 170 180 190 200
GNYVVQNEPD LRVMYITSEK FLNDLVDSMK EGKLNEFREK YRKKVDILLI
210 220 230 240 250
DDVQFLIGKT GVQTELFHTF NELHDSGKQI VICSDREPQK LSEFQDRLVS
260 270 280 290 300
RFQMGLVAKL EPPDEETRKS IARKMLEIEH GELPEEVLNF VAENVDDNLR
310 320 330 340 350
RLRGAIIKLL VYKETTGKEV DLKEAILLLK DFIKPNRVKA MDPIDELIEI
360 370 380 390 400
VAKVTGVPRE EILSNSRNVK ALTARRIGMY VAKNYLKSSL RTIAEKFNRS
410 420 430 440
HPVVVDSVKK VKDSLLKGNK QLKALIDEVI GEISRRALSG
Length:440
Mass (Da):50,304
Last modified:November 1, 1995 - v1
Checksum:i2E35ED82650A5C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24145 Genomic DNA. Translation: AAA65438.1.
AE000512 Genomic DNA. Translation: AAD36007.1.
PIRiG72317.
RefSeqiNP_228734.1. NC_000853.1.
WP_004080636.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36007; AAD36007; TM_0926.
GeneIDi898600.
KEGGitma:TM0926.
PATRICi23936783. VBITheMar51294_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24145 Genomic DNA. Translation: AAA65438.1.
AE000512 Genomic DNA. Translation: AAD36007.1.
PIRiG72317.
RefSeqiNP_228734.1. NC_000853.1.
WP_004080636.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z4RX-ray3.05A/B/C1-440[»]
2Z4SX-ray3.00A1-440[»]
ProteinModelPortaliP46798.
SMRiP46798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36007; AAD36007; TM_0926.
GeneIDi898600.
KEGGitma:TM0926.
PATRICi23936783. VBITheMar51294_0940.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiP46798.
KOiK02313.
OMAiQSKTRKR.

Miscellaneous databases

EvolutionaryTraceiP46798.
PROiP46798.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_THEMA
AccessioniPrimary (citable) accession number: P46798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.