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Protein

Ferredoxin

Gene

fdx

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

Cofactori

[4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101Iron-sulfur (4Fe-4S)1 Publication
Metal bindingi13 – 131Iron-sulfur (4Fe-4S)1 Publication
Metal bindingi16 – 161Iron-sulfur (4Fe-4S)1 Publication
Metal bindingi51 – 511Iron-sulfur (4Fe-4S)1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin
Gene namesi
Name:fdx
Ordered Locus Names:TM_0927
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060FerredoxinPRO_0000159203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 431 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi243274.TM0927.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Turni7 – 93Combined sources
Helixi15 – 195Combined sources
Turni21 – 233Combined sources
Beta strandi24 – 263Combined sources
Beta strandi30 – 356Combined sources
Helixi43 – 508Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ROFNMR-A1-60[»]
1VJWX-ray1.75A1-60[»]
ProteinModelPortaliP46797.
SMRiP46797. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 29284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini30 – 60314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG41084T3. Bacteria.
COG1141. LUCA.
InParanoidiP46797.
KOiK05337.
OMAiLDCAKDA.
OrthoDBiEOG60SCM3.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVRVDADAC IGCGVCENLC PDVFQLGDDG KAKVLQPETD LPCAKDAADS
60
CPTGAISVEE
Length:60
Mass (Da):6,213
Last modified:November 1, 1995 - v1
Checksum:iA00A03A13FDF1690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82178 Genomic DNA. Translation: CAA57669.1.
U24145 Genomic DNA. Translation: AAA65437.1.
AE000512 Genomic DNA. Translation: AAD36008.1.
PIRiS44350.
RefSeqiNP_228735.1. NC_000853.1.
WP_004080635.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36008; AAD36008; TM_0927.
GeneIDi898601.
KEGGitma:TM0927.
PATRICi23936785. VBITheMar51294_0941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82178 Genomic DNA. Translation: CAA57669.1.
U24145 Genomic DNA. Translation: AAA65437.1.
AE000512 Genomic DNA. Translation: AAD36008.1.
PIRiS44350.
RefSeqiNP_228735.1. NC_000853.1.
WP_004080635.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ROFNMR-A1-60[»]
1VJWX-ray1.75A1-60[»]
ProteinModelPortaliP46797.
SMRiP46797. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36008; AAD36008; TM_0927.
GeneIDi898601.
KEGGitma:TM0927.
PATRICi23936785. VBITheMar51294_0941.

Phylogenomic databases

eggNOGiENOG41084T3. Bacteria.
COG1141. LUCA.
InParanoidiP46797.
KOiK05337.
OMAiLDCAKDA.
OrthoDBiEOG60SCM3.

Miscellaneous databases

EvolutionaryTraceiP46797.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, assembly and evolution of a primordial ferredoxin from Thermotoga maritima."
    Darimont B., Sterner R.
    EMBO J. 13:1772-1781(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima."
    Macedo-Ribeiro S., Darimont B., Sterner R., Huber R.
    Structure 4:1291-1301(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
  4. "An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin."
    Sticht H., Wildegger G., Bentrop D., Darimont B., Sterner R., Roesch P.
    Eur. J. Biochem. 237:726-735(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiFER_THEMA
AccessioniPrimary (citable) accession number: P46797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 13, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.