P46786 (RL6_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L6

Gene names

Name:	rplF
Ordered Locus Names:	SCO4717
ORF Names:	SCD31.42

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. HAMAP-Rule MF_01365
Subunit structure	Part of the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the ribosomal protein L6P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	50S ribosomal protein L6 HAMAP-Rule MF_01365		PRO_0000131068
Experimental info
	Sequence conflict	9 – 10	2	IA → HR in CAA58132. Ref.1
	Sequence conflict	151 – 152	2	KL → NV in CAA58132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46786 [UniParc]. Last modified October 18, 2001. Version 2. Checksum: DD3DD8188BC909DC	FASTA	179	19,179
	10 20 30 40 50 60 MSRIGKLPIA VPAGVDVTID GRTVSVKGPK GSLTHTVVAP IDIAKGEDGV LNVTRPNDER 70 80 90 100 110 120 QSKALHGLSR TLVANMITGV TQGYVKKLEI SGVGYRVLAK GSNLEFSLGY SHPILVEAPE 130 140 150 160 170 GITFKVENPT HFSVEGIDKQ KVGEVAANIR KLRKPDPYKA KGVKYEGEVI RRKVGKAGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Loriaux A., Brans A., Dusart J. Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3(2) / NRRL B-16638.
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83011 Genomic DNA. Translation: CAA58132.1. AL939121 Genomic DNA. Translation: CAB82085.1.
PIR	S50001.
RefSeq	NP_628876.1. NC_003888.3.
3D structure databases
ProteinModelPortal	P46786.
SMR	P46786. Positions 7-179.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO4717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB82085; CAB82085; CAB82085.
GeneID	1100158.
KEGG	sco:SCO4717.
PATRIC	23739256. VBIStrCoe124346_4788.
Phylogenomic databases
eggNOG	COG0097.
HOGENOM	HOG000039903.
KO	K02933.
OMA	INNMVVG.
ProtClustDB	PRK05498.
Family and domain databases
Gene3D	3.90.930.12. 2 hits.
HAMAP	MF_01365_B. Ribosomal_L6_B.
InterPro	IPR000702. Ribosomal_L6. IPR020040. Ribosomal_L6_a/b-dom. IPR019906. Ribosomal_L6_bac-type. IPR002358. Ribosomal_L6_CS. [Graphical view]
PANTHER	PTHR11655. PTHR11655. 1 hit. PTHR11655:SF6. PTHR11655:SF6. 1 hit.
Pfam	PF00347. Ribosomal_L6. 2 hits. [Graphical view]
PIRSF	PIRSF002162. Ribosomal_L6. 1 hit.
PRINTS	PR00059. RIBOSOMALL6.
SUPFAM	SSF56053. Ribosomal_L6. 2 hits.
TIGRFAMs	TIGR03654. L6_bact. 1 hit.
PROSITE	PS00525. RIBOSOMAL_L6_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL6_STRCO

Accession

Primary (citable) accession number: P46786
Secondary accession number(s): Q9L0C5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 18, 2001
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program