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Protein

40S ribosomal protein S10-B

Gene

RPS10B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641).1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cytoplasmic translation Source: SGD
  • positive regulation of protein kinase activity Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • rRNA export from nucleus Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10-B
Gene namesi
Name:RPS10B
Ordered Locus Names:YMR230W
ORF Names:YM9959.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR230W.
SGDiS000004843. RPS10B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163771 – 10540S ribosomal protein S10-BAdd BLAST105

Post-translational modificationi

The N-terminus is not modified.

Proteomic databases

MaxQBiP46784.
PRIDEiP46784.
TopDownProteomicsiP46784.

PTM databases

iPTMnetiP46784.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:9559554). The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S) (PubMed:9559554). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:9559554). Interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity (PubMed:25437641).1 Publication

Protein-protein interaction databases

BioGridi35408. 49 interactors.
IntActiP46784. 9 interactors.
MINTiMINT-2788813.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Beta strandi19 – 22Combined sources4
Beta strandi33 – 37Combined sources5
Helixi39 – 51Combined sources13
Beta strandi54 – 58Combined sources5
Beta strandi65 – 68Combined sources4
Helixi70 – 79Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U3MX-ray3.00C0/c01-105[»]
ProteinModelPortaliP46784.
SMRiP46784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S10e family.Curated

Phylogenomic databases

HOGENOMiHOG000216624.
InParanoidiP46784.
KOiK02947.
OMAiFPATHSK.
OrthoDBiEOG092C5V0H.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005326. S10_plectin_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P46784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKQERNK IHQYLFQEGV VVAKKDFNQA KHEEIDTKNL YVIKALQSLT
60 70 80 90 100
SKGYVKTQFS WQYYYYTLTE EGVEYLREYL NLPEHIVPGT YIQERNPSQR

PQRRY
Length:105
Mass (Da):12,738
Last modified:November 1, 1995 - v1
Checksum:iBE50B625869963CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90201.1.
BK006946 Genomic DNA. Translation: DAA10129.1.
PIRiS57597.
RefSeqiNP_013957.1. NM_001182737.1.

Genome annotation databases

EnsemblFungiiYMR230W; YMR230W; YMR230W.
GeneIDi855270.
KEGGisce:YMR230W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90201.1.
BK006946 Genomic DNA. Translation: DAA10129.1.
PIRiS57597.
RefSeqiNP_013957.1. NM_001182737.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U3MX-ray3.00C0/c01-105[»]
ProteinModelPortaliP46784.
SMRiP46784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35408. 49 interactors.
IntActiP46784. 9 interactors.
MINTiMINT-2788813.

PTM databases

iPTMnetiP46784.

Proteomic databases

MaxQBiP46784.
PRIDEiP46784.
TopDownProteomicsiP46784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR230W; YMR230W; YMR230W.
GeneIDi855270.
KEGGisce:YMR230W.

Organism-specific databases

EuPathDBiFungiDB:YMR230W.
SGDiS000004843. RPS10B.

Phylogenomic databases

HOGENOMiHOG000216624.
InParanoidiP46784.
KOiK02947.
OMAiFPATHSK.
OrthoDBiEOG092C5V0H.

Enzyme and pathway databases

BioCyciYEAST:G3O-32911-MONOMER.

Miscellaneous databases

PROiP46784.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005326. S10_plectin_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03501. S10_plectin. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRS10B_YEAST
AccessioniPrimary (citable) accession number: P46784
Secondary accession number(s): D6W055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7650 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for S10 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.