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Protein

40S ribosomal protein S10

Gene

RPS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 40S ribosomal subunit.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S10
Alternative name(s):
Small ribosomal subunit protein eS101 Publication
Gene namesi
Name:RPS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124614.13
HGNCiHGNC:10383 RPS10
MIMi603632 gene
neXtProtiNX_P46783

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 9 (DBA9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:613308

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi138 – 139KK → RR: Abolishes monoubiquitination by ZNF598, leading to enhanced readthrough on the poly(A)-stall sequences. 2 Publications2
Mutagenesisi158R → K: Weakly methylated. Complete loss of methylation; inefficient assembly into ribosomes; instability; increased degradation by the proteasomal pathway; decreased interaction with NPM1; absence of localization in the granular component (GC) region of the nucleolus; when associated with K-160. 1 Publication1
Mutagenesisi160R → K: Weakly methylated. Complete loss of methylation; inefficient assembly into ribosomes; instability; increased degradation by the proteasomal pathway; decreased interaction with NPM1; absence of localization in the granular component (GC) region of the nucleolus; when associated with K-158. 1 Publication1

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6204
GeneReviewsiRPS10
MalaCardsiRPS10
MIMi613308 phenotype
OpenTargetsiENSG00000124614
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34779

Polymorphism and mutation databases

BioMutaiRPS10
DMDMi1173177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163601 – 16540S ribosomal protein S10Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphotyrosineBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei146PhosphoserineBy similarity1
Modified residuei153Omega-N-methylarginineBy similarity1
Modified residuei158Symmetric dimethylarginine1 Publication1
Modified residuei160Symmetric dimethylarginine1 Publication1

Post-translational modificationi

Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.1 Publication
Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).2 Publications

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP46783
MaxQBiP46783
PaxDbiP46783
PeptideAtlasiP46783
PRIDEiP46783
TopDownProteomicsiP46783

PTM databases

iPTMnetiP46783
PhosphoSitePlusiP46783
SwissPalmiP46783

Expressioni

Gene expression databases

BgeeiENSG00000124614
CleanExiHS_RPS10
ExpressionAtlasiP46783 baseline and differential
GenevisibleiP46783 HS

Organism-specific databases

HPAiHPA047268
HPA048084

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.1 Publication

Protein-protein interaction databases

BioGridi112118, 177 interactors
CORUMiP46783
IntActiP46783, 45 interactors
MINTiP46783
STRINGi9606.ENSP00000347271

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SK1-165[»]
4V6Xelectron microscopy5.00AK1-165[»]
5A2Qelectron microscopy3.90K1-165[»]
5AJ0electron microscopy3.50BK1-165[»]
5FLXelectron microscopy3.90K1-165[»]
5LKSelectron microscopy3.60SK1-165[»]
5OA3electron microscopy4.30K1-165[»]
5T2Celectron microscopy3.60Av1-165[»]
5VYCX-ray6.00K1/K2/K3/K4/K5/K61-165[»]
6EK0electron microscopy2.90SK1-165[»]
6FECelectron microscopy6.30t1-98[»]
ProteinModelPortaliP46783
SMRiP46783
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3344 Eukaryota
COG5045 LUCA
GeneTreeiENSGT00440000034918
HOVERGENiHBG001253
InParanoidiP46783
KOiK02947
PhylomeDBiP46783
TreeFamiTF319100

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037447 Rps10
IPR005326 S10_plectin_N
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12146 PTHR12146, 1 hit
PfamiView protein in Pfam
PF03501 S10_plectin, 1 hit

Sequencei

Sequence statusi: Complete.

P46783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ
60 70 80 90 100
SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE
110 120 130 140 150
TGRPRPKGLE GERPARLTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF
160
QFRGGFGRGR GQPPQ
Length:165
Mass (Da):18,898
Last modified:November 1, 1995 - v1
Checksum:i64106DFCD97AABA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14972 mRNA Translation: AAA85660.1
AK311797 mRNA Translation: BAG34740.1
AL157372 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03784.1
BC001032 mRNA Translation: AAH01032.1
BC001955 mRNA Translation: AAH01955.1
BC005012 mRNA Translation: AAH05012.1
BC070235 mRNA Translation: AAH70235.1
BC071946 mRNA Translation: AAH71946.1
BC073799 mRNA Translation: AAH73799.1
AB007151 Genomic DNA Translation: BAA25817.1
CCDSiCCDS4792.1
PIRiS55918
RefSeqiNP_001005.1, NM_001014.4
NP_001190174.1, NM_001203245.2
NP_001191020.1, NM_001204091.1
UniGeneiHs.406620
Hs.645317

Genome annotation databases

EnsembliENST00000326199; ENSP00000347271; ENSG00000124614
ENST00000621356; ENSP00000481646; ENSG00000124614
GeneIDi6204
KEGGihsa:6204
UCSCiuc003ojm.4 human

Similar proteinsi

Entry informationi

Entry nameiRS10_HUMAN
AccessioniPrimary (citable) accession number: P46783
Secondary accession number(s): B2R4E3, Q5TZC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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