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Protein

40S ribosomal protein S5

Gene

RPS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • regulation of translational fidelity Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: UniProtKB
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083845-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S5
Cleaved into the following chain:
Gene namesi
Name:RPS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10426. RPS5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083845.
PharmGKBiPA34841.

Polymorphism and mutation databases

BioMutaiRPS5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003703691 – 20440S ribosomal protein S5Add BLAST204
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00001245262 – 20440S ribosomal protein S5, N-terminally processedAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine; in 40S ribosomal protein S5; alternateCombined sources1 Publication1
Modified residuei2N-acetylthreonine; in 40S ribosomal protein S5, N-terminally processedCombined sources2 Publications1
Modified residuei14PhosphothreonineCombined sources1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP46782.
MaxQBiP46782.
PaxDbiP46782.
PeptideAtlasiP46782.
PRIDEiP46782.
TopDownProteomicsiP46782.

2D gel databases

SWISS-2DPAGEP46782.

PTM databases

iPTMnetiP46782.
PhosphoSitePlusiP46782.
SwissPalmiP46782.

Expressioni

Gene expression databases

BgeeiENSG00000083845.
CleanExiHS_RPS5.
ExpressionAtlasiP46782. baseline and differential.
GenevisibleiP46782. HS.

Organism-specific databases

HPAiHPA055878.

Interactioni

Protein-protein interaction databases

BioGridi112107. 178 interactors.
IntActiP46782. 28 interactors.
MINTiMINT-1142463.
STRINGi9606.ENSP00000196551.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SF1-204[»]
4V6Xelectron microscopy5.00AF1-204[»]
5A2Qelectron microscopy3.90F1-204[»]
5AJ0electron microscopy3.50BF1-204[»]
5FLXelectron microscopy3.90F1-204[»]
ProteinModelPortaliP46782.
SMRiP46782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S7P family.Curated

Phylogenomic databases

eggNOGiKOG3291. Eukaryota.
COG0049. LUCA.
GeneTreeiENSGT00390000010806.
HOGENOMiHOG000039066.
HOVERGENiHBG028547.
InParanoidiP46782.
KOiK02989.
PhylomeDBiP46782.
TreeFamiTF300872.

Family and domain databases

CDDicd14867. uS7_Eukaryote. 1 hit.
Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR005716. Ribosomal_S5/S7_euk/arc.
IPR020606. Ribosomal_S7_CS.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF002122. RPS7p_RPS7a_RPS5e_RPS7o. 1 hit.
SUPFAMiSSF47973. SSF47973. 1 hit.
TIGRFAMsiTIGR01028. uS7_euk_arch. 1 hit.
PROSITEiPS00052. RIBOSOMAL_S7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP
60 70 80 90 100
HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII
110 120 130 140 150
HLLTGENPLQ VLVNAIINSG PREDSTRIGR AGTVRRQAVD VSPLRRVNQA
160 170 180 190 200
IWLLCTGARE AAFRNIKTIA ECLADELINA AKGSSNSYAI KKKDELERVA

KSNR
Length:204
Mass (Da):22,876
Last modified:January 23, 2007 - v4
Checksum:iDFE2FD5AAFCFD894
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59 – 60KR → NA in AAA85658 (PubMed:7772601).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14970 mRNA. Translation: AAA85658.1.
AB061853 Genomic DNA. Translation: BAB79493.1.
AK311938 mRNA. Translation: BAG34879.1.
CH471135 Genomic DNA. Translation: EAW72581.1.
BC015405 mRNA. Translation: AAH15405.1.
BC018151 mRNA. Translation: AAH18151.1.
AB007149 Genomic DNA. Translation: BAA25815.1.
CCDSiCCDS12978.1.
PIRiS55916.
RefSeqiNP_001000.2. NM_001009.3.
UniGeneiHs.378103.

Genome annotation databases

EnsembliENST00000196551; ENSP00000196551; ENSG00000083845.
ENST00000596046; ENSP00000472985; ENSG00000083845.
ENST00000601521; ENSP00000470114; ENSG00000083845.
GeneIDi6193.
KEGGihsa:6193.
UCSCiuc002qsn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14970 mRNA. Translation: AAA85658.1.
AB061853 Genomic DNA. Translation: BAB79493.1.
AK311938 mRNA. Translation: BAG34879.1.
CH471135 Genomic DNA. Translation: EAW72581.1.
BC015405 mRNA. Translation: AAH15405.1.
BC018151 mRNA. Translation: AAH18151.1.
AB007149 Genomic DNA. Translation: BAA25815.1.
CCDSiCCDS12978.1.
PIRiS55916.
RefSeqiNP_001000.2. NM_001009.3.
UniGeneiHs.378103.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SF1-204[»]
4V6Xelectron microscopy5.00AF1-204[»]
5A2Qelectron microscopy3.90F1-204[»]
5AJ0electron microscopy3.50BF1-204[»]
5FLXelectron microscopy3.90F1-204[»]
ProteinModelPortaliP46782.
SMRiP46782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112107. 178 interactors.
IntActiP46782. 28 interactors.
MINTiMINT-1142463.
STRINGi9606.ENSP00000196551.

PTM databases

iPTMnetiP46782.
PhosphoSitePlusiP46782.
SwissPalmiP46782.

Polymorphism and mutation databases

BioMutaiRPS5.

2D gel databases

SWISS-2DPAGEP46782.

Proteomic databases

EPDiP46782.
MaxQBiP46782.
PaxDbiP46782.
PeptideAtlasiP46782.
PRIDEiP46782.
TopDownProteomicsiP46782.

Protocols and materials databases

DNASUi6193.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000196551; ENSP00000196551; ENSG00000083845.
ENST00000596046; ENSP00000472985; ENSG00000083845.
ENST00000601521; ENSP00000470114; ENSG00000083845.
GeneIDi6193.
KEGGihsa:6193.
UCSCiuc002qsn.4. human.

Organism-specific databases

CTDi6193.
GeneCardsiRPS5.
H-InvDBHIX0020415.
HGNCiHGNC:10426. RPS5.
HPAiHPA055878.
MIMi603630. gene.
neXtProtiNX_P46782.
OpenTargetsiENSG00000083845.
PharmGKBiPA34841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3291. Eukaryota.
COG0049. LUCA.
GeneTreeiENSGT00390000010806.
HOGENOMiHOG000039066.
HOVERGENiHBG028547.
InParanoidiP46782.
KOiK02989.
PhylomeDBiP46782.
TreeFamiTF300872.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083845-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS5. human.
GeneWikiiRPS5.
GenomeRNAii6193.
PROiP46782.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083845.
CleanExiHS_RPS5.
ExpressionAtlasiP46782. baseline and differential.
GenevisibleiP46782. HS.

Family and domain databases

CDDicd14867. uS7_Eukaryote. 1 hit.
Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR005716. Ribosomal_S5/S7_euk/arc.
IPR020606. Ribosomal_S7_CS.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF002122. RPS7p_RPS7a_RPS5e_RPS7o. 1 hit.
SUPFAMiSSF47973. SSF47973. 1 hit.
TIGRFAMsiTIGR01028. uS7_euk_arch. 1 hit.
PROSITEiPS00052. RIBOSOMAL_S7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS5_HUMAN
AccessioniPrimary (citable) accession number: P46782
Secondary accession number(s): B2R4T2, Q96BN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 166 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.