P46782 (RS5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S5

Cleaved into the following chain:

1. 40S ribosomal protein S5, N-terminally processed

Gene names

Name:

RPS5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S7P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome regulation of translational fidelity Inferred from genetic interaction PubMed 17901157. Source: UniProtKB translational elongation Traceable author statement. Source: Reactome translational initiation Inferred by curator PubMed 15883184. Source: UniProtKB translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.9. Source: UniProtKB
Molecular_function	mRNA binding Inferred from direct assay PubMed 18464793. Source: UniProtKB structural constituent of ribosome Inferred from direct assay PubMed 15883184. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	40S ribosomal protein S5		PRO_0000370369
	Initiator methionine	1	1	Removed; alternate Ref.6 Ref.7
	Chain	2 – 204	203	40S ribosomal protein S5, N-terminally processed		PRO_0000124526
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine; in 40S ribosomal protein S5; alternate Ref.7
	Modified residue	2	1	N-acetylthreonine; in 40S ribosomal protein S5, N-terminally processed Ref.6 Ref.7
	Modified residue	47	1	N6-acetyllysine Ref.10
Experimental info
	Sequence conflict	59 – 60	2	KR → NA in AAA85658. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46782 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: DFE2FD5AAFCFD894	FASTA	204	22,876
	10 20 30 40 50 60 MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR 70 80 90 100 110 120 FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII HLLTGENPLQ VLVNAIINSG 130 140 150 160 170 180 PREDSTRIGR AGTVRRQAVD VSPLRRVNQA IWLLCTGARE AAFRNIKTIA ECLADELINA 190 200 AKGSSNSYAI KKKDELERVA KSNR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs." Frigerio J.-M., Dagorn J.-C., Iovanna J.L. Biochim. Biophys. Acta 1262:64-68(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[2]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone and Ovary.
[6]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-18; 23-42; 48-55; 137-145 AND 168-182, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[7]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-18; 23-42; 137-159 AND 168-182, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT MET-1 AND THR-2, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-204.
[9]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 192-197. Tissue: Placenta.
[10]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-47, MASS SPECTROMETRY.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14970 mRNA. Translation: AAA85658.1. AB061853 Genomic DNA. Translation: BAB79493.1. AK311938 mRNA. Translation: BAG34879.1. CH471135 Genomic DNA. Translation: EAW72581.1. BC015405 mRNA. Translation: AAH15405.1. BC018151 mRNA. Translation: AAH18151.1. AB007149 Genomic DNA. Translation: BAA25815.1.
IPI	IPI00008433.
PIR	S55916.
RefSeq	NP_001000.2. NM_001009.3.
UniGene	Hs.378103.
3D structure databases
ProteinModelPortal	P46782.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46782. 10 interactions.
MINT	MINT-1142463.
STRING	9606.ENSP00000196551.
PTM databases
PhosphoSite	P46782.
Polymorphism databases
DMDM	22002064.
2D gel databases
SWISS-2DPAGE	P46782.
Proteomic databases
PaxDb	P46782.
PeptideAtlas	P46782.
PRIDE	P46782.
Protocols and materials databases
DNASU	6193.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000196551; ENSP00000196551; ENSG00000083845. ENST00000596046; ENSP00000472985; ENSG00000083845. ENST00000601521; ENSP00000470114; ENSG00000083845.
GeneID	6193.
KEGG	hsa:6193.
UCSC	uc002qsn.3. human.
Organism-specific databases
CTD	6193.
GeneCards	GC19P059147.
H-InvDB	HIX0020415.
HGNC	HGNC:10426. RPS5.
HPA	HPA055878.
MIM	603630. gene.
neXtProt	NX_P46782.
PharmGKB	PA34841.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0049.
HOGENOM	HOG000039066.
HOVERGEN	HBG028547.
InParanoid	P46782.
KO	K02989.
OMA	PREETTR.
OrthoDB	EOG4H9XMF.
PhylomeDB	P46782.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	P46782.
CleanEx	HS_RPS5.
Genevestigator	P46782.
GermOnline	ENSG00000083845. Homo sapiens.
Family and domain databases
Gene3D	1.10.455.10. 1 hit.
InterPro	IPR000235. Ribosomal_S5/S7. IPR005716. Ribosomal_S5/S7_euk/arc. IPR020606. Ribosomal_S7_CS. IPR023798. Ribosomal_S7_dom. [Graphical view]
PANTHER	PTHR11205. PTHR11205. 1 hit. PTHR11205:SF1. PTHR11205:SF1. 1 hit.
Pfam	PF00177. Ribosomal_S7. 1 hit. [Graphical view]
PIRSF	PIRSF002122. RPS7p_RPS7a_RPS5e_RPS7o. 1 hit.
SUPFAM	SSF47973. Ribosomal_S7. 1 hit.
TIGRFAMs	TIGR01028. S7_S5_E_A. 1 hit.
PROSITE	PS00052. RIBOSOMAL_S7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS5. human.
GenomeRNAi	6193.
NextBio	24049.
SOURCE	Search...

Entry information

Entry name

RS5_HUMAN

Accession

Primary (citable) accession number: P46782
Secondary accession number(s): B2R4T2, Q96BN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 131 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.