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Protein

40S ribosomal protein S9

Gene

RPS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central
  • translation regulator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S9
Alternative name(s):
Small ribosomal subunit protein uS41 Publication
Gene namesi
Name:RPS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170889.13
HGNCiHGNC:10442 RPS9
MIMi603631 gene
neXtProtiNX_P46781

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6203
OpenTargetsiENSG00000170889
PharmGKBiPA34857

Polymorphism and mutation databases

BioMutaiRPS9
DMDMi20178311

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001326892 – 19440S ribosomal protein S9Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66N6-acetyllysineBy similarity1
Cross-linki93Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei116N6-acetyllysineBy similarity1
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei153PhosphoserineCombined sources1
Modified residuei155N6-acetyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP46781
MaxQBiP46781
PaxDbiP46781
PeptideAtlasiP46781
PRIDEiP46781
TopDownProteomicsiP46781

PTM databases

iPTMnetiP46781
PhosphoSitePlusiP46781
SwissPalmiP46781

Expressioni

Gene expression databases

BgeeiENSG00000170889
CleanExiHS_RPS9
ExpressionAtlasiP46781 baseline and differential
GenevisibleiP46781 HS

Organism-specific databases

HPAiHPA048746

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-351206,EBI-518675

Protein-protein interaction databases

BioGridi112117, 177 interactors
CORUMiP46781
IntActiP46781, 41 interactors
MINTiP46781
STRINGi9606.ENSP00000302896

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SJ1-194[»]
4V6Xelectron microscopy5.00AJ1-194[»]
5A2Qelectron microscopy3.90J1-194[»]
5AJ0electron microscopy3.50BJ1-194[»]
5FLXelectron microscopy3.90J1-194[»]
5LKSelectron microscopy3.60SJ1-194[»]
5OA3electron microscopy4.30J1-194[»]
5T2Celectron microscopy3.60AL1-194[»]
5VYCX-ray6.00J1/J2/J3/J4/J5/J61-194[»]
6EK0electron microscopy2.90SJ1-194[»]
6FECelectron microscopy6.30K7-188[»]
ProteinModelPortaliP46781
SMRiP46781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 182S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3301 Eukaryota
COG0522 LUCA
GeneTreeiENSGT00550000074829
HOGENOMiHOG000194525
HOVERGENiHBG001135
InParanoidiP46781
KOiK02997
OMAiTHGHIAI
OrthoDBiEOG091G0S57
PhylomeDBiP46781
TreeFamiTF300795

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR005710 Ribosomal_S4/S9_euk/arc
IPR001912 Ribosomal_S4/S9_N
IPR018079 Ribosomal_S4_CS
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
TIGRFAMsiTIGR01018 uS4_arch, 1 hit
PROSITEiView protein in PROSITE
PS00632 RIBOSOMAL_S4, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL
60 70 80 90 100
AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL
110 120 130 140 150
KIEDFLERRL QTQVFKLGLA KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR
160 170 180 190
LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK GQGGAGAGDD EEED
Length:194
Mass (Da):22,591
Last modified:January 23, 2007 - v3
Checksum:iE9CE3CBD59524F81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84I → L in AAA85659 (PubMed:7772601).Curated1
Sequence conflicti165 – 167YGG → TGV in AAA85659 (PubMed:7772601).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036543137V → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14971 mRNA Translation: AAA85659.1
AB061839 Genomic DNA Translation: BAB79477.1
CU457734 Genomic DNA No translation available.
CU151838 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72209.1
BC000802 mRNA Translation: AAH00802.1
BC007410 mRNA Translation: AAH07410.1
BC007434 mRNA Translation: AAH07434.1
BC007857 mRNA Translation: AAH07857.1
BC068055 mRNA Translation: AAH68055.1
BC071940 mRNA Translation: AAH71940.1
BC096756 mRNA Translation: AAH96756.1
AB007150 Genomic DNA Translation: BAA25816.1
CCDSiCCDS12884.1
PIRiS55917
RefSeqiNP_001004.2, NM_001013.3
NP_001308630.1, NM_001321701.1
NP_001308631.1, NM_001321702.1
NP_001308633.1, NM_001321704.1
UniGeneiHs.467284
Hs.546288

Genome annotation databases

EnsembliENST00000302907; ENSP00000302896; ENSG00000170889
ENST00000391752; ENSP00000375632; ENSG00000170889
ENST00000391753; ENSP00000375633; ENSG00000170889
ENST00000610826; ENSP00000481764; ENSG00000278270
ENST00000611921; ENSP00000480662; ENSG00000274950
ENST00000614737; ENSP00000482338; ENSG00000278270
ENST00000615346; ENSP00000481553; ENSG00000274646
ENST00000616082; ENSP00000482475; ENSG00000274646
ENST00000616536; ENSP00000481822; ENSG00000274950
ENST00000616877; ENSP00000481194; ENSG00000274950
ENST00000619229; ENSP00000479917; ENSG00000278270
ENST00000620940; ENSP00000483179; ENSG00000274646
GeneIDi6203
KEGGihsa:6203
UCSCiuc002qdx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRS9_HUMAN
AccessioniPrimary (citable) accession number: P46781
Secondary accession number(s): A9C4C1, Q4QRK7, Q9BVZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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