Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P46778

- RL21_HUMAN

UniProt

P46778 - RL21_HUMAN

Protein

60S ribosomal protein L21

Gene

RPL21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L21
    Gene namesi
    Name:RPL21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:10313. RPL21.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA

    Pathology & Biotechi

    Involvement in diseasei

    Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.

    Keywords - Diseasei

    Disease mutation, Hypotrichosis

    Organism-specific databases

    Orphaneti55654. Hypotrichosis simplex.
    PharmGKBiPA34683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 16015960S ribosomal protein L21PRO_0000149669Add
    BLAST

    Proteomic databases

    MaxQBiP46778.
    PaxDbiP46778.
    PRIDEiP46778.

    2D gel databases

    SWISS-2DPAGEP46778.

    PTM databases

    PhosphoSiteiP46778.

    Expressioni

    Gene expression databases

    BgeeiP46778.
    CleanExiHS_RPL21.
    GenevestigatoriP46778.

    Organism-specific databases

    HPAiHPA047252.

    Interactioni

    Protein-protein interaction databases

    BioGridi112064. 111 interactions.
    IntActiP46778. 28 interactions.
    MINTiMINT-3016420.
    STRINGi9606.ENSP00000346027.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00T1-160[»]
    ProteinModelPortaliP46778.
    SMRiP46778. Positions 2-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L21e family.Curated

    Phylogenomic databases

    eggNOGiCOG2139.
    HOVERGENiHBG001518.
    InParanoidiP46778.
    KOiK02889.
    OMAiGTGTIQK.
    PhylomeDBiP46778.
    TreeFamiTF314640.

    Family and domain databases

    Gene3Di2.30.30.70. 1 hit.
    InterProiIPR001147. Ribosomal_L21e.
    IPR018259. Ribosomal_L21e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR20981. PTHR20981. 1 hit.
    PfamiPF01157. Ribosomal_L21e. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46778-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK    50
    GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRIN VRIEHIKHSK 100
    SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL 150
    LEPIPYEFMA 160
    Length:160
    Mass (Da):18,565
    Last modified:January 23, 2007 - v2
    Checksum:iC51D0B5E8EB9D69E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721V → A in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti78 – 781K → E in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti104 – 1041S → N in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti112 – 1121N → D in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti115 – 1151K → E in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti120 – 1201K → Q in AAA93231. (PubMed:7581362)Curated
    Sequence conflicti131 – 1311Q → H in AAA80462. (PubMed:7951316)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151F → S.
    Corresponds to variant rs17085349 [ dbSNP | Ensembl ].
    VAR_034459
    Natural varianti32 – 321R → Q in HTS. 1 Publication
    VAR_066030

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89401 mRNA. Translation: CAA61582.1.
    U14967 mRNA. Translation: AAA85655.1.
    AB061826 Genomic DNA. Translation: BAB79464.1.
    BC001603 mRNA. Translation: AAH01603.1.
    BC007505 mRNA. Translation: AAH07505.1.
    BC062981 mRNA. Translation: AAH62981.1.
    BC070184 mRNA. Translation: AAH70184.1.
    BC070323 mRNA. Translation: AAH70323.1.
    BC070330 mRNA. Translation: AAH70330.1.
    U25789 mRNA. Translation: AAA93231.1.
    L38826 Genomic DNA. Translation: AAA80462.1.
    AB007176 Genomic DNA. Translation: BAA25835.1.
    CCDSiCCDS9320.1.
    PIRiS55913.
    RefSeqiNP_000973.2. NM_000982.3.
    UniGeneiHs.381123.
    Hs.535873.

    Genome annotation databases

    EnsembliENST00000272274; ENSP00000351021; ENSG00000122026.
    ENST00000311549; ENSP00000346027; ENSG00000122026.
    ENST00000319826; ENSP00000370574; ENSG00000122026.
    ENST00000326092; ENSP00000370569; ENSG00000122026.
    GeneIDi6144.
    KEGGihsa:6144.
    UCSCiuc001uqz.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89401 mRNA. Translation: CAA61582.1 .
    U14967 mRNA. Translation: AAA85655.1 .
    AB061826 Genomic DNA. Translation: BAB79464.1 .
    BC001603 mRNA. Translation: AAH01603.1 .
    BC007505 mRNA. Translation: AAH07505.1 .
    BC062981 mRNA. Translation: AAH62981.1 .
    BC070184 mRNA. Translation: AAH70184.1 .
    BC070323 mRNA. Translation: AAH70323.1 .
    BC070330 mRNA. Translation: AAH70330.1 .
    U25789 mRNA. Translation: AAA93231.1 .
    L38826 Genomic DNA. Translation: AAA80462.1 .
    AB007176 Genomic DNA. Translation: BAA25835.1 .
    CCDSi CCDS9320.1.
    PIRi S55913.
    RefSeqi NP_000973.2. NM_000982.3.
    UniGenei Hs.381123.
    Hs.535873.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 T 1-160 [» ]
    ProteinModelPortali P46778.
    SMRi P46778. Positions 2-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112064. 111 interactions.
    IntActi P46778. 28 interactions.
    MINTi MINT-3016420.
    STRINGi 9606.ENSP00000346027.

    PTM databases

    PhosphoSitei P46778.

    2D gel databases

    SWISS-2DPAGE P46778.

    Proteomic databases

    MaxQBi P46778.
    PaxDbi P46778.
    PRIDEi P46778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272274 ; ENSP00000351021 ; ENSG00000122026 .
    ENST00000311549 ; ENSP00000346027 ; ENSG00000122026 .
    ENST00000319826 ; ENSP00000370574 ; ENSG00000122026 .
    ENST00000326092 ; ENSP00000370569 ; ENSG00000122026 .
    GeneIDi 6144.
    KEGGi hsa:6144.
    UCSCi uc001uqz.1. human.

    Organism-specific databases

    CTDi 6144.
    GeneCardsi GC13P027827.
    H-InvDB HIX0096689.
    HGNCi HGNC:10313. RPL21.
    HPAi HPA047252.
    MIMi 603636. gene.
    neXtProti NX_P46778.
    Orphaneti 55654. Hypotrichosis simplex.
    PharmGKBi PA34683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2139.
    HOVERGENi HBG001518.
    InParanoidi P46778.
    KOi K02889.
    OMAi GTGTIQK.
    PhylomeDBi P46778.
    TreeFami TF314640.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL21. human.
    GeneWikii RPL21.
    GenomeRNAii 6144.
    NextBioi 23871.
    PROi P46778.
    SOURCEi Search...

    Gene expression databases

    Bgeei P46778.
    CleanExi HS_RPL21.
    Genevestigatori P46778.

    Family and domain databases

    Gene3Di 2.30.30.70. 1 hit.
    InterProi IPR001147. Ribosomal_L21e.
    IPR018259. Ribosomal_L21e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR20981. PTHR20981. 1 hit.
    Pfami PF01157. Ribosomal_L21e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01171. RIBOSOMAL_L21E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs."
      Frigerio J.-M., Dagorn J.-C., Iovanna J.L.
      Biochim. Biophys. Acta 1262:64-68(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lymph, Muscle, Pancreas, Prostate and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-160.
      Tissue: Brain.
    6. "A map of 75 human ribosomal protein genes."
      Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
      Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-154.
    7. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
      Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
      J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-15, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
    11. "Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex."
      Zhou C., Zang D., Jin Y., Wu H., Liu Z., Du J., Zhang J.
      Hum. Mutat. 32:710-714(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HTS GLN-32.

    Entry informationi

    Entry nameiRL21_HUMAN
    AccessioniPrimary (citable) accession number: P46778
    Secondary accession number(s): Q16699
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 153 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3