P46776 (RL27A_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 100.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 60S ribosomal protein L27a | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 148 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Belongs to the ribosomal protein L15P family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | endocrine pancreas development Traceable author statement. Source: Reactome mRNA metabolic processTraceable author statement. Source: Reactome translational elongationTraceable author statement. Source: Reactome translational terminationTraceable author statement. Source: Reactome viral transcriptionTraceable author statement. Source: Reactome |
| Cellular component | cytosolic large ribosomal subunit Inferred from direct assay. Source: UniProtKB |
| Molecular function | RNA binding Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct structural constituent of ribosomeNon-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| GTF2F2 | P13984 | 2 | EBI-350581,EBI-1030560 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 148 | 147 | 60S ribosomal protein L27a | PRO_0000104879 | |||||
Amino acid modifications | |||||||||
| Modified residue | 47 | 1 | N6-acetyllysine Ref.9 | ||||||
| Modified residue | 55 | 1 | N6-acetyllysine Ref.9 | ||||||
| Modified residue | 68 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 110 | 1 | N6-acetyllysine Ref.9 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs." Frigerio J.-M., Dagorn J.-C., Iovanna J.L. Biochim. Biophys. Acta 1262:64-68(1995) [PubMed: 7772601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon. |
| [2] | "Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A." Kusuda J., Hirai M., Tanuma R., Hirata M., Hashimoto K. Cytogenet. Cell Genet. 85:248-251(1999) [PubMed: 10449908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Lymph. |
| [6] | "A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed: 9582194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-106. |
| [7] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [8] | "Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, MASS SPECTROMETRY. |
| [9] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-47; LYS-55 AND LYS-110, MASS SPECTROMETRY. |
| [10] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U14968 mRNA. Translation: AAA85656.1. AB020236 Genomic DNA. Translation: BAA77361.1. AK311767 mRNA. Translation: BAG34710.1. CH471064 Genomic DNA. Translation: EAW68619.1. BC005326 mRNA. Translation: AAH05326.1. BC020169 mRNA. Translation: AAH20169.1. AB007178 Genomic DNA. Translation: BAA25837.1. |
| IPI | IPI00456758. |
| PIR | S55914. |
| RefSeq | NP_000981.1. NM_000990.4. |
| UniGene | Hs.523463. |
3D structure databases | |
| ProteinModelPortal | P46776. |
| SMR | P46776. Positions 6-147. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P46776. 7 interactions. |
| MINT | MINT-1150308. |
| STRING | P46776. |
PTM databases | |
| PhosphoSite | P46776. |
Polymorphism databases | |
| DMDM | 1173017. |
2D gel databases | |
| SWISS-2DPAGE | P46776. |
Proteomic databases | |
| PRIDE | P46776. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000314138; ENSP00000346015; ENSG00000166441. |
| GeneID | 6157. |
| KEGG | hsa:6157. |
| UCSC | uc001mgs.2. human. |
Organism-specific databases | |
| CTD | 6157. |
| GeneCards | GC11P008703. |
| H-InvDB | HIX0009426. |
| HGNC | HGNC:10329. RPL27A. |
| MIM | 603637. gene. |
| neXtProt | NX_P46776. |
| PharmGKB | PA34708. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG07279. |
| HOGENOM | HBG727142. |
| HOVERGEN | HBG054587. |
| InParanoid | P46776. |
| OMA | KNQHYCP. |
| OrthoDB | EOG4CJVJC. |
| PhylomeDB | P46776. |
Enzyme and pathway databases | |
| Reactome | REACT_111045. Developmental Biology. REACT_111217. Metabolism. REACT_15380. Diabetes pathways. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression. |
Gene expression databases | |
| ArrayExpress | P46776. |
| Bgee | P46776. |
| CleanEx | HS_RPL27A. |
| Genevestigator | P46776. |
| GermOnline | ENSG00000166441. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001196. Ribosomal_L15_CS. IPR021131. Ribosomal_L18e/L15P. [Graphical view] |
| KO | K02900. |
| Pfam | PF00828. Ribosomal_L18e. 1 hit. [Graphical view] |
| SUPFAM | SSF52080. Ribosomal_L18e/L15. 1 hit. |
| PROSITE | PS00475. RIBOSOMAL_L15. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 23911. |
| SOURCE | Search... |
Entry information
| Entry name | RL27A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P46776 Secondary accession number(s): B2R4B3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Ribosomal proteins Ribosomal proteins families and list of entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with