Reviewed, UniProtKB/Swiss-Prot P46776 (RL27A_HUMAN)

Names and origin

Protein names

Recommended name:
    60S ribosomal protein L27a

Gene names

Name:

RPL27A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L15P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	translational elongation Inferred from Experiment. Source: Reactome
Cellular component	cytosolic large ribosomal subunit Ref.1 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc structural constituent of ribosome Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 148	147	60S ribosomal protein L27a		PRO_0000104879
Amino acid modifications
	Modified residue	68	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P46776-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CB5E09C91507798F	FASTA	148	16,561
	10 20 30 40 50 60 MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH 70 80 90 100 110 120 YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ 130 140 PVIVKAKFFS RRAEEKIKSV GGACVLVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs." Frigerio J.-M., Dagorn J.-C., Iovanna J.L. Biochim. Biophys. Acta 1262:64-68(1995) [PubMed: 7772601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[2]	"Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A." Kusuda J., Hirai M., Tanuma R., Hirata M., Hashimoto K. Cytogenet. Cell Genet. 85:248-251(1999) [PubMed: 10449908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Lymph.
[4]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed: 9582194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-106.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14968 mRNA. Translation: AAA85656.1. AB020236 Genomic DNA. Translation: BAA77361.1. BC005326 mRNA. Translation: AAH05326.1. BC020169 mRNA. Translation: AAH20169.1. AB007178 Genomic DNA. Translation: BAA25837.1.
IPI	IPI00456758.
PIR	S55914.
RefSeq	NP_000981.1.
UniGene	Hs.523463
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P46776. 2 interactions.
PTM databases
PhosphoSite	P46776.
2-D gel databases
SWISS-2DPAGE	P46776.
Proteomic databases
PRIDE	P46776.
Genome annotation databases
Ensembl	ENSG00000166441. Homo sapiens. [Contig view]
GeneID	6157.
KEGG	hsa:6157.
Organism-specific databases
GeneCards	GC06M153645. GC11P008660.
HGNC	HGNC:10329. RPL27A.
MIM	603637. gene.
PharmGKB	PA34708.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P46776.
HOVERGEN	P46776.
OMA	P46776. HHHRTNL.
Enzyme and pathway databases
Reactome	REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
Bgee	P46776.
CleanEx	HS_RPL27A.
GermOnline	ENSG00000166441. Homo sapiens.
Family and domain databases
InterPro	IPR001196. Ribosomal_L15. [Graphical view]
Pfam	PF00256. L15. 1 hit. [Graphical view]
PROSITE	PS00475. RIBOSOMAL_L15. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	23911.
SOURCE	Search...

Entry information

Entry name

RL27A_HUMAN

Accession

Primary (citable) accession number: P46776

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)