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Protein

40S ribosomal protein SA

Gene

rps-0

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Gene namesi
Name:rps-0UniRule annotation
ORF Names:B0393.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0393.1; CE00854; WBGene00004469; rps-0.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001343522 – 27640S ribosomal protein SAAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineUniRule annotation1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP46769.
PaxDbiP46769.
PeptideAtlasiP46769.
PRIDEiP46769.

2D gel databases

World-2DPAGEi0020:P46769.

PTM databases

iPTMnetiP46769.

Expressioni

Developmental stagei

Expressed at a stable level throughout development.1 Publication

Gene expression databases

BgeeiWBGene00004469.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps-21.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
rps-21P491974EBI-313262,EBI-313268

Protein-protein interaction databases

BioGridi40862. 9 interactors.
DIPiDIP-26217N.
IntActiP46769. 4 interactors.
MINTiMINT-1037948.
STRINGi6239.B0393.1.2.

Structurei

3D structure databases

ProteinModelPortaliP46769.
SMRiP46769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0830. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000015036.
HOGENOMiHOG000232073.
InParanoidiP46769.
KOiK02998.
OMAiYWILARE.
OrthoDBiEOG091G0J0Q.
PhylomeDBiP46769.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_03015. Ribosomal_S2_euk. 1 hit.
InterProiView protein in InterPro
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiView protein in Pfam
PF00318. Ribosomal_S2. 1 hit.
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. uS2_euk_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGAAHSAL TEEDVMKLLA TQAHLGSTNL NFQMQQYVYK RRFDGPNIIN
60 70 80 90 100
VKKTWEKLLL AARAIAAVEN PADVVVVSAR PYAQRALLKF AAHTGATAIF
110 120 130 140 150
GRFSPGCLTN QIQKTFKEPR LLVISDPRID HQAVTEASYV GVPVISFVNT
160 170 180 190 200
ESPLKLIDIG VPCNNKGERS IGLMWWMLAR EILILRGKIS RQTGFVLEGK
210 220 230 240 250
EIMPDLYFYR DPTETEKEET GAHADVAEAQ EYQQPTDIDF TTQGGKVDDW
260 270
AAETATWTAE TKTTEEWANA PTQSNW
Length:276
Mass (Da):30,703
Last modified:January 23, 2007 - v3
Checksum:i51CB51C5C1B923DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37983 Genomic DNA. Translation: CAA86061.1.
PIRiT18742.
RefSeqiNP_497978.1. NM_065577.5.
UniGeneiCel.10142.

Genome annotation databases

EnsemblMetazoaiB0393.1.1; B0393.1.1; WBGene00004469.
B0393.1.2; B0393.1.2; WBGene00004469.
GeneIDi175628.
KEGGicel:CELE_B0393.1.
UCSCiB0393.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37983 Genomic DNA. Translation: CAA86061.1.
PIRiT18742.
RefSeqiNP_497978.1. NM_065577.5.
UniGeneiCel.10142.

3D structure databases

ProteinModelPortaliP46769.
SMRiP46769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40862. 9 interactors.
DIPiDIP-26217N.
IntActiP46769. 4 interactors.
MINTiMINT-1037948.
STRINGi6239.B0393.1.2.

PTM databases

iPTMnetiP46769.

2D gel databases

World-2DPAGEi0020:P46769.

Proteomic databases

EPDiP46769.
PaxDbiP46769.
PeptideAtlasiP46769.
PRIDEiP46769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0393.1.1; B0393.1.1; WBGene00004469.
B0393.1.2; B0393.1.2; WBGene00004469.
GeneIDi175628.
KEGGicel:CELE_B0393.1.
UCSCiB0393.1.1. c. elegans.

Organism-specific databases

CTDi175628.
WormBaseiB0393.1; CE00854; WBGene00004469; rps-0.

Phylogenomic databases

eggNOGiKOG0830. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000015036.
HOGENOMiHOG000232073.
InParanoidiP46769.
KOiK02998.
OMAiYWILARE.
OrthoDBiEOG091G0J0Q.
PhylomeDBiP46769.

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiPR:P46769.

Gene expression databases

BgeeiWBGene00004469.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_03015. Ribosomal_S2_euk. 1 hit.
InterProiView protein in InterPro
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiView protein in Pfam
PF00318. Ribosomal_S2. 1 hit.
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. uS2_euk_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSSA_CAEEL
AccessioniPrimary (citable) accession number: P46769
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.