P46769 (RSSA_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein SA

Gene names

Name:	rps-0
ORF Names:	B0393.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits By similarity.
Subunit structure	Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps-21 By similarity.
Subcellular location	Cytoplasm.
Developmental stage	Expressed at a stable level throughout development. Ref.3
Sequence similarities	Belongs to the ribosomal protein S2P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from Biological aspect of Ancestor. Source: RefGenome endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from Biological aspect of Ancestor. Source: RefGenome growth Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticle Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase rRNA export from nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome ribosomal small subunit assembly Inferred from Biological aspect of Ancestor. Source: RefGenome translation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	90S preribosome Inferred from Biological aspect of Ancestor. Source: RefGenome cytosolic small ribosomal subunit Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural constituent of ribosome Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
rps-21	P49197	4	EBI-313262,EBI-313268

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 276	275	40S ribosomal protein SA		PRO_0000134352
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P46769 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 51CB51C5C1B923DE	FASTA	276	30,703
	10 20 30 40 50 60 MSGGAAHSAL TEEDVMKLLA TQAHLGSTNL NFQMQQYVYK RRFDGPNIIN VKKTWEKLLL 70 80 90 100 110 120 AARAIAAVEN PADVVVVSAR PYAQRALLKF AAHTGATAIF GRFSPGCLTN QIQKTFKEPR 130 140 150 160 170 180 LLVISDPRID HQAVTEASYV GVPVISFVNT ESPLKLIDIG VPCNNKGERS IGLMWWMLAR 190 200 210 220 230 240 EILILRGKIS RQTGFVLEGK EIMPDLYFYR DPTETEKEET GAHADVAEAQ EYQQPTDIDF 250 260 270 TTQGGKVDDW AAETATWTAE TKTTEEWANA PTQSNW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	Bienvenut W.V. Submitted (AUG-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-17; 42-52; 64-80; 129-155; 170-180 AND 192-200, MASS SPECTROMETRY, ACETYLATION AT SER-2.
[3]	"Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis." Tabuse Y., Nabetani T., Tsugita A. Proteomics 5:2876-2891(2005) [PubMed: 15996007] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z37983 Genomic DNA. Translation: CAA86061.1.
PIR	T18742.
RefSeq	NP_497978.1. NM_065577.4.
UniGene	Cel.10142.
3D structure databases
ProteinModelPortal	P46769.
SMR	P46769. Positions 10-210.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26217N.
IntAct	P46769. 4 interactions.
MINT	MINT-1037948.
STRING	P46769.
2D gel databases
World-2DPAGE	0020:P46769.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0393.1.1; B0393.1.1; B0393.1. B0393.1.2; B0393.1.2; B0393.1.
GeneID	175628.
KEGG	cel:B0393.1.
UCSC	B0393.1.1. c. elegans.
Organism-specific databases
CTD	175628.
WormBase	B0393.1; CE00854; WBGene00004469; rps-0.
Phylogenomic databases
eggNOG	meNOG04038.
GeneTree	EMGT00050000005297.
HOGENOM	HBG736296.
InParanoid	P46769.
OMA	LAANCHI.
PhylomeDB	P46769.
Family and domain databases
InterPro	IPR001865. Ribosomal_S2. IPR018130. Ribosomal_S2_CS. IPR005707. Ribosomal_S2_euk/arc. IPR023591. Ribosomal_S2_flav_dom. [Graphical view]
KO	K02998.
PANTHER	PTHR11489. Ribosomal_S2_e/a. 1 hit.
Pfam	PF00318. Ribosomal_S2. 2 hits. [Graphical view]
PRINTS	PR00395. RIBOSOMALS2.
SUPFAM	SSF52313. Ribosomal_S2. 1 hit.
TIGRFAMs	TIGR01012. Sa_S2_E_A. 1 hit.
PROSITE	PS00962. RIBOSOMAL_S2_1. 1 hit. PS00963. RIBOSOMAL_S2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	888964.

Entry information

Entry name

RSSA_CAEEL

Accession

Primary (citable) accession number: P46769

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project