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Protein

Unconventional myosin-Ib

Gene

Myo1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi108 – 1158ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
MIH-L
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Gene namesi
Name:Myo1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107752. Myo1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107Unconventional myosin-IbPRO_0000123443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineBy similarity
Cross-linki287 – 287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki287 – 287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP46735.
PaxDbiP46735.
PeptideAtlasiP46735.
PRIDEiP46735.

PTM databases

iPTMnetiP46735.
PhosphoSiteiP46735.
SwissPalmiP46735.

Expressioni

Tissue specificityi

Prominent expression is seen in the brain, lung and liver. It is also expressed in the heart and testis. A high level expression is seen in virtually all neurons (but not glia) in the postnatal and adult mouse brain and in neuroblasts of the cerebellar external granular layer.

Gene expression databases

BgeeiENSMUSG00000018417.
CleanExiMM_MYO1B.
ExpressionAtlasiP46735. baseline and differential.
GenevisibleiP46735. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201663. 1 interaction.
IntActiP46735. 7 interactions.
MINTiMINT-1864019.
STRINGi10090.ENSMUSP00000018561.

Structurei

3D structure databases

ProteinModelPortaliP46735.
SMRiP46735. Positions 5-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 701687Myosin motorAdd
BLAST
Domaini704 – 72724IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini728 – 74922IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 77829IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini780 – 80728IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini808 – 83730IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini923 – 1107185TH1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni592 – 5998Actin-bindingSequence analysis

Sequence similaritiesi

Contains 5 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiP46735.
KOiK10356.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P46735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKMEVKSSL LDNMIGVGDM VLLEPLNEET FIDNLKKRFD HNEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE DYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL YKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFLDHEAEA VLEVVAAVLK LGNIEFKPES RVNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTSIDQVVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTTLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKAGHSLI
560 570 580 590 600
KSLFPEGNPA KVNLKRPPTA GSQFKASVAT LMRNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFNES LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEHSF GRSKIFIRNP RTLFQLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKRS QVVIAAWYRR YAQQKRYQQI
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAATTIAAYW HGTQARRELK
810 820 830 840 850
RLKEEARRKH AVAVIWAYWL GLKVRREYRK FFRANAGKKI YEFTLQRIVQ
860 870 880 890 900
KYLLEMKNKM PSLSPIDKNW PSRPYLFLDS THKELKRIFH LWRCKKYRDQ
910 920 930 940 950
FTDQQKLIYE EKLEASELFK DKKALYPSSV GQPFQGAYLE INKNPKYKKL
960 970 980 990 1000
KDAIEEKIII AEVVNKINRA NGKSTSRIFL LTNNNLLLAD QKSGQIKSEV
1010 1020 1030 1040 1050
PLVDVTKVSM SSQNDGFFAV HLKEGSEAAS KGDFLFSSDH LIEMATKLYR
1060 1070 1080 1090 1100
TTLSQTKQKL NIEISDEFLV QFRQDKVCVK FIQGNQKNGS VPTCKRKNNR

LLEVAVP
Length:1,107
Mass (Da):128,564
Last modified:July 27, 2011 - v3
Checksum:i42B339708CA9B7E6
GO
Isoform 2 (identifier: P46735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-819: Missing.

Show »
Length:1,078
Mass (Da):125,022
Checksum:iDDC6FAC4197C80ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441I → R in CAA49604 (PubMed:8458427).Curated
Sequence conflicti260 – 2601I → Y in CAA49604 (PubMed:8458427).Curated
Sequence conflicti304 – 3041N → I in AAA39800 (PubMed:8449986).Curated
Sequence conflicti307 – 31711KEICELTSIDQ → NEKFASRPASVK in AAA39800 (PubMed:8449986).CuratedAdd
BLAST
Sequence conflicti333 – 3331Q → R in AAA39800 (PubMed:8449986).Curated
Sequence conflicti546 – 5461G → D in AAA39800 (PubMed:8449986).Curated
Sequence conflicti570 – 5712AG → RS in CAA49604 (PubMed:8458427).Curated
Sequence conflicti742 – 7421A → E in CAA49604 (PubMed:8458427).Curated
Sequence conflicti809 – 8102KH → ND in CAA49604 (PubMed:8458427).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei791 – 81929Missing in isoform 2. 1 PublicationVSP_003347Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00923 mRNA. Translation: AAA39800.1.
AK141207 mRNA. Translation: BAE24587.1.
CH466548 Genomic DNA. Translation: EDK99961.1.
BC046300 mRNA. Translation: AAH46300.1.
X69987 mRNA. Translation: CAA49604.1.
CCDSiCCDS14942.1. [P46735-1]
CCDS69887.1. [P46735-2]
PIRiA45438.
RefSeqiNP_034993.2. NM_010863.4. [P46735-1]
UniGeneiMm.3390.
Mm.465429.

Genome annotation databases

EnsembliENSMUST00000046390; ENSMUSP00000040447; ENSMUSG00000018417. [P46735-1]
GeneIDi17912.
KEGGimmu:17912.
UCSCiuc007axr.3. mouse. [P46735-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00923 mRNA. Translation: AAA39800.1.
AK141207 mRNA. Translation: BAE24587.1.
CH466548 Genomic DNA. Translation: EDK99961.1.
BC046300 mRNA. Translation: AAH46300.1.
X69987 mRNA. Translation: CAA49604.1.
CCDSiCCDS14942.1. [P46735-1]
CCDS69887.1. [P46735-2]
PIRiA45438.
RefSeqiNP_034993.2. NM_010863.4. [P46735-1]
UniGeneiMm.3390.
Mm.465429.

3D structure databases

ProteinModelPortaliP46735.
SMRiP46735. Positions 5-728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201663. 1 interaction.
IntActiP46735. 7 interactions.
MINTiMINT-1864019.
STRINGi10090.ENSMUSP00000018561.

PTM databases

iPTMnetiP46735.
PhosphoSiteiP46735.
SwissPalmiP46735.

Proteomic databases

MaxQBiP46735.
PaxDbiP46735.
PeptideAtlasiP46735.
PRIDEiP46735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046390; ENSMUSP00000040447; ENSMUSG00000018417. [P46735-1]
GeneIDi17912.
KEGGimmu:17912.
UCSCiuc007axr.3. mouse. [P46735-1]

Organism-specific databases

CTDi4430.
MGIiMGI:107752. Myo1b.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiP46735.
KOiK10356.

Miscellaneous databases

ChiTaRSiMyo1b. mouse.
PROiP46735.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018417.
CleanExiMM_MYO1B.
ExpressionAtlasiP46735. baseline and differential.
GenevisibleiP46735. MM.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1B_MOUSE
AccessioniPrimary (citable) accession number: P46735
Secondary accession number(s): P70244, Q80VD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.