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P46734

- MP2K3_HUMAN

UniProt

P46734 - MP2K3_HUMAN

Protein

Dual specificity mitogen-activated protein kinase kinase 3

Gene

MAP2K3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (01 Nov 2002)
      Previous versions | rss
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    Functioni

    Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by dual phosphorylation on Ser-218 and Thr-222.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931ATPPROSITE-ProRule annotation
    Active sitei190 – 1901Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 789ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase activity Source: ProtInc
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: UniProtKB
    5. protein serine/threonine kinase activity Source: UniProtKB-KW
    6. protein tyrosine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of MAPK activity Source: Reactome
    2. cardiac muscle contraction Source: Ensembl
    3. inflammatory response Source: Ensembl
    4. innate immune response Source: Reactome
    5. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    6. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    7. positive regulation of protein kinase activity Source: UniProtKB
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. regulation of cytokine biosynthetic process Source: Ensembl
    10. signal transduction Source: ProtInc
    11. stress-activated MAPK cascade Source: Reactome
    12. toll-like receptor 10 signaling pathway Source: Reactome
    13. toll-like receptor 2 signaling pathway Source: Reactome
    14. toll-like receptor 3 signaling pathway Source: Reactome
    15. toll-like receptor 4 signaling pathway Source: Reactome
    16. toll-like receptor 5 signaling pathway Source: Reactome
    17. toll-like receptor 9 signaling pathway Source: Reactome
    18. toll-like receptor signaling pathway Source: Reactome
    19. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    20. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    21. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.12.2. 2681.
    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    SignaLinkiP46734.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
    Short name:
    MAP kinase kinase 3
    Short name:
    MAPKK 3
    Alternative name(s):
    MAPK/ERK kinase 3
    Short name:
    MEK 3
    Stress-activated protein kinase kinase 2
    Short name:
    SAPK kinase 2
    Short name:
    SAPKK-2
    Short name:
    SAPKK2
    Gene namesi
    Name:MAP2K3
    Synonyms:MEK3, MKK3, PRKMK3, SKK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6843. MAP2K3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. membrane Source: UniProtKB
    3. nucleoplasm Source: Reactome

    Pathology & Biotechi

    Involvement in diseasei

    Defects in MAP2K3 may be involved in colon cancer.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi218 – 2181S → A: Inactivation. 1 Publication
    Mutagenesisi218 – 2181S → E: Constitutive activation. 1 Publication
    Mutagenesisi222 – 2221T → A: Inactivation. 1 Publication
    Mutagenesisi222 – 2221T → E: Constitutive activation. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    PharmGKBiPA30588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Dual specificity mitogen-activated protein kinase kinase 3PRO_0000086378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications
    Modified residuei3 – 31Phosphoserine2 Publications
    Modified residuei15 – 151Phosphoserine2 Publications
    Modified residuei218 – 2181Phosphoserine2 Publications
    Modified residuei222 – 2221Phosphothreonine2 Publications

    Post-translational modificationi

    Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.1 Publication
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP46734.
    PaxDbiP46734.
    PRIDEiP46734.

    PTM databases

    PhosphoSiteiP46734.

    Miscellaneous databases

    PMAP-CutDBP46734.

    Expressioni

    Tissue specificityi

    Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

    Gene expression databases

    ArrayExpressiP46734.
    BgeeiP46734.
    CleanExiHS_MAP2K3.
    GenevestigatoriP46734.

    Organism-specific databases

    HPAiCAB018548.
    HPA044497.

    Interactioni

    Subunit structurei

    Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DYRK1BQ9Y4632EBI-602462,EBI-634187
    LRRK2Q5S0075EBI-602462,EBI-5323863
    MAP3K5Q996832EBI-602462,EBI-476263
    MAPK14Q165392EBI-602462,EBI-73946

    Protein-protein interaction databases

    BioGridi111592. 28 interactions.
    DIPiDIP-34242N.
    IntActiP46734. 11 interactions.
    MINTiMINT-4300215.
    STRINGi9606.ENSP00000345083.

    Structurei

    3D structure databases

    ProteinModelPortaliP46734.
    SMRiP46734. Positions 16-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 325262Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000234206.
    HOVERGENiHBG108518.
    KOiK04432.
    OMAiNYLELME.
    PhylomeDBiP46734.
    TreeFamiTF350701.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: P46734-1) [UniParc]FASTAAdd to Basket

    Also known as: 3b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI    50
    TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN 100
    SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF 150
    YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK 200
    EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD 250
    VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 300
    FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS 347
    Length:347
    Mass (Da):39,318
    Last modified:November 1, 2002 - v2
    Checksum:iA80BA4FDFF8F75A2
    GO
    Isoform 1 (identifier: P46734-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.

    Show »
    Length:318
    Mass (Da):36,173
    Checksum:i966821BE4B76E8FA
    GO
    Isoform 2 (identifier: P46734-3) [UniParc]FASTAAdd to Basket

    Also known as: 3c

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: MESPASSQPASMPQSK → MGVQGTLMSRDSQTPHLLSIL

    Show »
    Length:352
    Mass (Da):39,940
    Checksum:iF59612D9001EA9C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti341 – 3411E → K(PubMed:7839144)Curated
    Sequence conflicti341 – 3411E → K1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261R → T.1 Publication
    VAR_040817
    Natural varianti40 – 401P → T.
    Corresponds to variant rs33911218 [ dbSNP | Ensembl ].
    VAR_046062
    Natural varianti55 – 551R → T.
    Corresponds to variant rs36047035 [ dbSNP | Ensembl ].
    VAR_061742
    Natural varianti68 – 681S → P.1 Publication
    Corresponds to variant rs34105301 [ dbSNP | Ensembl ].
    VAR_046063
    Natural varianti84 – 841A → T.1 Publication
    Corresponds to variant rs2305873 [ dbSNP | Ensembl ].
    VAR_046064
    Natural varianti90 – 901M → I.1 Publication
    Corresponds to variant rs36076766 [ dbSNP | Ensembl ].
    VAR_046065
    Natural varianti94 – 941R → L.1 Publication
    Corresponds to variant rs56067280 [ dbSNP | Ensembl ].
    VAR_046066
    Natural varianti96 – 961R → W.1 Publication
    Corresponds to variant rs56216806 [ dbSNP | Ensembl ].
    VAR_046067
    Natural varianti175 – 1751R → W in colon cancer. 1 Publication
    VAR_014208
    Natural varianti215 – 2151L → V in colon cancer. 1 Publication
    VAR_014209
    Natural varianti293 – 2931R → H.1 Publication
    Corresponds to variant rs35206134 [ dbSNP | Ensembl ].
    VAR_046068
    Natural varianti339 – 3391V → M.1 Publication
    Corresponds to variant rs2363198 [ dbSNP | Ensembl ].
    VAR_046069

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929Missing in isoform 1. 2 PublicationsVSP_004878Add
    BLAST
    Alternative sequencei1 – 1616MESPA…MPQSK → MGVQGTLMSRDSQTPHLLSI L in isoform 2. CuratedVSP_004877Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36719 mRNA. Translation: AAC41718.1.
    D87116 mRNA. Translation: BAA13248.1.
    U66839 mRNA. Translation: AAB40652.1.
    U66840 Genomic DNA. Translation: AAB40653.1.
    AK093838 mRNA. Translation: BAG52769.1.
    BC032478 mRNA. Translation: AAH32478.1.
    CCDSiCCDS11217.1. [P46734-1]
    CCDS11218.1. [P46734-2]
    RefSeqiNP_002747.2. NM_002756.4. [P46734-2]
    NP_659731.1. NM_145109.2. [P46734-1]
    XP_005256779.1. XM_005256722.1. [P46734-2]
    XP_005256780.1. XM_005256723.1. [P46734-2]
    UniGeneiHs.514012.

    Genome annotation databases

    EnsembliENST00000316920; ENSP00000319139; ENSG00000034152. [P46734-2]
    ENST00000342679; ENSP00000345083; ENSG00000034152. [P46734-1]
    ENST00000361818; ENSP00000355081; ENSG00000034152. [P46734-2]
    GeneIDi5606.
    KEGGihsa:5606.
    UCSCiuc002gys.3. human. [P46734-1]

    Polymorphism databases

    DMDMi24638466.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36719 mRNA. Translation: AAC41718.1 .
    D87116 mRNA. Translation: BAA13248.1 .
    U66839 mRNA. Translation: AAB40652.1 .
    U66840 Genomic DNA. Translation: AAB40653.1 .
    AK093838 mRNA. Translation: BAG52769.1 .
    BC032478 mRNA. Translation: AAH32478.1 .
    CCDSi CCDS11217.1. [P46734-1 ]
    CCDS11218.1. [P46734-2 ]
    RefSeqi NP_002747.2. NM_002756.4. [P46734-2 ]
    NP_659731.1. NM_145109.2. [P46734-1 ]
    XP_005256779.1. XM_005256722.1. [P46734-2 ]
    XP_005256780.1. XM_005256723.1. [P46734-2 ]
    UniGenei Hs.514012.

    3D structure databases

    ProteinModelPortali P46734.
    SMRi P46734. Positions 16-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111592. 28 interactions.
    DIPi DIP-34242N.
    IntActi P46734. 11 interactions.
    MINTi MINT-4300215.
    STRINGi 9606.ENSP00000345083.

    Chemistry

    BindingDBi P46734.
    ChEMBLi CHEMBL2109.
    GuidetoPHARMACOLOGYi 2064.

    PTM databases

    PhosphoSitei P46734.

    Polymorphism databases

    DMDMi 24638466.

    Proteomic databases

    MaxQBi P46734.
    PaxDbi P46734.
    PRIDEi P46734.

    Protocols and materials databases

    DNASUi 5606.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316920 ; ENSP00000319139 ; ENSG00000034152 . [P46734-2 ]
    ENST00000342679 ; ENSP00000345083 ; ENSG00000034152 . [P46734-1 ]
    ENST00000361818 ; ENSP00000355081 ; ENSG00000034152 . [P46734-2 ]
    GeneIDi 5606.
    KEGGi hsa:5606.
    UCSCi uc002gys.3. human. [P46734-1 ]

    Organism-specific databases

    CTDi 5606.
    GeneCardsi GC17P021187.
    HGNCi HGNC:6843. MAP2K3.
    HPAi CAB018548.
    HPA044497.
    MIMi 602315. gene.
    neXtProti NX_P46734.
    PharmGKBi PA30588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000234206.
    HOVERGENi HBG108518.
    KOi K04432.
    OMAi NYLELME.
    PhylomeDBi P46734.
    TreeFami TF350701.

    Enzyme and pathway databases

    BRENDAi 2.7.12.2. 2681.
    Reactomei REACT_169436. Oxidative Stress Induced Senescence.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    SignaLinki P46734.

    Miscellaneous databases

    ChiTaRSi MAP2K3. human.
    GeneWikii MAP2K3.
    GenomeRNAii 5606.
    NextBioi 21784.
    PMAP-CutDB P46734.
    PROi P46734.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46734.
    Bgeei P46734.
    CleanExi HS_MAP2K3.
    Genevestigatori P46734.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
      Derijard B., Raingeaud J., Barrett T., Wu I.-H., Han J., Ulevitch R.J., Davis R.J.
      Science 267:682-685(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2."
      Moriguchi T., Toyoshima F., Gotoh Y., Iwamatsu A., Irie K., Mori E., Kuroyanagi N., Hagiwara M., Matsumoto K., Nishida E.
      J. Biol. Chem. 271:26981-26988(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. Han J.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 2 AND 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Leukocyte.
    6. "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."
      Raingeaud J., Whitmarsh A.J., Barrett T., Derijard B., Davis R.J.
      Mol. Cell. Biol. 16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-218 AND THR-222, MUTAGENESIS OF SER-218 AND THR-222.
    7. "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2."
      Chen Z., Cobb M.H.
      J. Biol. Chem. 276:16070-16075(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY TAOK2.
    8. "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha."
      Lim S., Jin K., Friedman E.
      J. Biol. Chem. 277:25040-25046(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYRK1B.
      Tissue: Muscle.
    9. "Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."
      McLaughlin N.J., Banerjee A., Kelher M.R., Gamboni-Robertson F., Hamiel C., Sheppard F.R., Moore E.E., Silliman C.C.
      J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    10. "Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation."
      Mukherjee S., Keitany G., Li Y., Wang Y., Ball H.L., Goldsmith E.J., Orth K.
      Science 312:1211-1214(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YOPJ, ACETYLATION.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Mutation analyses of 268 candidate genes in human tumor cell lines."
      Teng D.-H., Chen Y., Lian L., Ha P.C., Tavtigian S.V., Wong A.K.C.
      Genomics 74:352-364(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS COLON CANCER TRP-175 AND VAL-215.
    16. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-26; PRO-68; THR-84; ILE-90; LEU-94; TRP-96; HIS-293 AND MET-339.

    Entry informationi

    Entry nameiMP2K3_HUMAN
    AccessioniPrimary (citable) accession number: P46734
    Secondary accession number(s): B3KSK7
    , Q99441, Q9UE71, Q9UE72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 2002
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3