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P46734

- MP2K3_HUMAN

UniProt

P46734 - MP2K3_HUMAN

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Protein
Dual specificity mitogen-activated protein kinase kinase 3
Gene
MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by dual phosphorylation on Ser-218 and Thr-222.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATP By similarity
Active sitei190 – 1901Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 789ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase activity Source: RefGenome
  3. protein binding Source: UniProtKB
  4. protein kinase binding Source: UniProtKB
  5. protein tyrosine kinase activity Source: UniProtKB-KW
  6. receptor signaling protein serine/threonine kinase activity Source: RefGenome

GO - Biological processi

  1. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  2. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  3. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  4. activation of MAPK activity Source: Reactome
  5. cardiac muscle contraction Source: Ensembl
  6. inflammatory response Source: Ensembl
  7. innate immune response Source: Reactome
  8. positive regulation of protein kinase activity Source: UniProtKB
  9. positive regulation of transcription, DNA-templated Source: UniProtKB
  10. regulation of cytokine biosynthetic process Source: Ensembl
  11. signal transduction Source: ProtInc
  12. stress-activated MAPK cascade Source: Reactome
  13. toll-like receptor 10 signaling pathway Source: Reactome
  14. toll-like receptor 2 signaling pathway Source: Reactome
  15. toll-like receptor 3 signaling pathway Source: Reactome
  16. toll-like receptor 4 signaling pathway Source: Reactome
  17. toll-like receptor 5 signaling pathway Source: Reactome
  18. toll-like receptor 9 signaling pathway Source: Reactome
  19. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  20. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  21. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 2681.
ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
SignaLinkiP46734.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
Short name:
MAP kinase kinase 3
Short name:
MAPKK 3
Alternative name(s):
MAPK/ERK kinase 3
Short name:
MEK 3
Stress-activated protein kinase kinase 2
Short name:
SAPK kinase 2
Short name:
SAPKK-2
Short name:
SAPKK2
Gene namesi
Name:MAP2K3
Synonyms:MEK3, MKK3, PRKMK3, SKK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6843. MAP2K3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: Reactome
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Defects in MAP2K3 may be involved in colon cancer.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi218 – 2181S → A: Inactivation. 1 Publication
Mutagenesisi218 – 2181S → E: Constitutive activation. 1 Publication
Mutagenesisi222 – 2221T → A: Inactivation. 1 Publication
Mutagenesisi222 – 2221T → E: Constitutive activation. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

PharmGKBiPA30588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Dual specificity mitogen-activated protein kinase kinase 3
PRO_0000086378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei3 – 31Phosphoserine1 Publication
Modified residuei15 – 151Phosphoserine1 Publication
Modified residuei218 – 2181Phosphoserine1 Publication
Modified residuei222 – 2221Phosphothreonine1 Publication

Post-translational modificationi

Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.2 Publications
Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP46734.
PaxDbiP46734.
PRIDEiP46734.

PTM databases

PhosphoSiteiP46734.

Miscellaneous databases

PMAP-CutDBP46734.

Expressioni

Tissue specificityi

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Gene expression databases

ArrayExpressiP46734.
BgeeiP46734.
CleanExiHS_MAP2K3.
GenevestigatoriP46734.

Organism-specific databases

HPAiCAB018548.
HPA044497.

Interactioni

Subunit structurei

Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DYRK1BQ9Y4632EBI-602462,EBI-634187
LRRK2Q5S0075EBI-602462,EBI-5323863
MAP3K5Q996832EBI-602462,EBI-476263
MAPK14Q165392EBI-602462,EBI-73946

Protein-protein interaction databases

BioGridi111592. 27 interactions.
DIPiDIP-34242N.
IntActiP46734. 8 interactions.
MINTiMINT-4300215.
STRINGi9606.ENSP00000345083.

Structurei

3D structure databases

ProteinModelPortaliP46734.
SMRiP46734. Positions 16-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 325262Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
KOiK04432.
OMAiNYLELME.
PhylomeDBiP46734.
TreeFamiTF350701.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: P46734-1) [UniParc]FASTAAdd to Basket

Also known as: 3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI    50
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN 100
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF 150
YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK 200
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD 250
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 300
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS 347
Length:347
Mass (Da):39,318
Last modified:November 1, 2002 - v2
Checksum:iA80BA4FDFF8F75A2
GO
Isoform 1 (identifier: P46734-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:318
Mass (Da):36,173
Checksum:i966821BE4B76E8FA
GO
Isoform 2 (identifier: P46734-3) [UniParc]FASTAAdd to Basket

Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MESPASSQPASMPQSK → MGVQGTLMSRDSQTPHLLSIL

Show »
Length:352
Mass (Da):39,940
Checksum:iF59612D9001EA9C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261R → T.1 Publication
VAR_040817
Natural varianti40 – 401P → T.
Corresponds to variant rs33911218 [ dbSNP | Ensembl ].
VAR_046062
Natural varianti55 – 551R → T.
Corresponds to variant rs36047035 [ dbSNP | Ensembl ].
VAR_061742
Natural varianti68 – 681S → P.1 Publication
Corresponds to variant rs34105301 [ dbSNP | Ensembl ].
VAR_046063
Natural varianti84 – 841A → T.1 Publication
Corresponds to variant rs2305873 [ dbSNP | Ensembl ].
VAR_046064
Natural varianti90 – 901M → I.1 Publication
Corresponds to variant rs36076766 [ dbSNP | Ensembl ].
VAR_046065
Natural varianti94 – 941R → L.1 Publication
Corresponds to variant rs56067280 [ dbSNP | Ensembl ].
VAR_046066
Natural varianti96 – 961R → W.1 Publication
Corresponds to variant rs56216806 [ dbSNP | Ensembl ].
VAR_046067
Natural varianti175 – 1751R → W in colon cancer. 1 Publication
VAR_014208
Natural varianti215 – 2151L → V in colon cancer. 1 Publication
VAR_014209
Natural varianti293 – 2931R → H.1 Publication
Corresponds to variant rs35206134 [ dbSNP | Ensembl ].
VAR_046068
Natural varianti339 – 3391V → M.1 Publication
Corresponds to variant rs2363198 [ dbSNP | Ensembl ].
VAR_046069

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 1.
VSP_004878Add
BLAST
Alternative sequencei1 – 1616MESPA…MPQSK → MGVQGTLMSRDSQTPHLLSI L in isoform 2.
VSP_004877Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti341 – 3411E → K1 Publication
Sequence conflicti341 – 3411E → K1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36719 mRNA. Translation: AAC41718.1.
D87116 mRNA. Translation: BAA13248.1.
U66839 mRNA. Translation: AAB40652.1.
U66840 Genomic DNA. Translation: AAB40653.1.
AK093838 mRNA. Translation: BAG52769.1.
BC032478 mRNA. Translation: AAH32478.1.
CCDSiCCDS11217.1. [P46734-1]
CCDS11218.1. [P46734-2]
RefSeqiNP_002747.2. NM_002756.4. [P46734-2]
NP_659731.1. NM_145109.2. [P46734-1]
XP_005256779.1. XM_005256722.1. [P46734-2]
XP_005256780.1. XM_005256723.1. [P46734-2]
UniGeneiHs.514012.

Genome annotation databases

EnsembliENST00000316920; ENSP00000319139; ENSG00000034152. [P46734-2]
ENST00000342679; ENSP00000345083; ENSG00000034152. [P46734-1]
ENST00000361818; ENSP00000355081; ENSG00000034152. [P46734-2]
GeneIDi5606.
KEGGihsa:5606.
UCSCiuc002gys.3. human. [P46734-1]

Polymorphism databases

DMDMi24638466.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36719 mRNA. Translation: AAC41718.1 .
D87116 mRNA. Translation: BAA13248.1 .
U66839 mRNA. Translation: AAB40652.1 .
U66840 Genomic DNA. Translation: AAB40653.1 .
AK093838 mRNA. Translation: BAG52769.1 .
BC032478 mRNA. Translation: AAH32478.1 .
CCDSi CCDS11217.1. [P46734-1 ]
CCDS11218.1. [P46734-2 ]
RefSeqi NP_002747.2. NM_002756.4. [P46734-2 ]
NP_659731.1. NM_145109.2. [P46734-1 ]
XP_005256779.1. XM_005256722.1. [P46734-2 ]
XP_005256780.1. XM_005256723.1. [P46734-2 ]
UniGenei Hs.514012.

3D structure databases

ProteinModelPortali P46734.
SMRi P46734. Positions 16-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111592. 27 interactions.
DIPi DIP-34242N.
IntActi P46734. 8 interactions.
MINTi MINT-4300215.
STRINGi 9606.ENSP00000345083.

Chemistry

BindingDBi P46734.
ChEMBLi CHEMBL2109.
GuidetoPHARMACOLOGYi 2064.

PTM databases

PhosphoSitei P46734.

Polymorphism databases

DMDMi 24638466.

Proteomic databases

MaxQBi P46734.
PaxDbi P46734.
PRIDEi P46734.

Protocols and materials databases

DNASUi 5606.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316920 ; ENSP00000319139 ; ENSG00000034152 . [P46734-2 ]
ENST00000342679 ; ENSP00000345083 ; ENSG00000034152 . [P46734-1 ]
ENST00000361818 ; ENSP00000355081 ; ENSG00000034152 . [P46734-2 ]
GeneIDi 5606.
KEGGi hsa:5606.
UCSCi uc002gys.3. human. [P46734-1 ]

Organism-specific databases

CTDi 5606.
GeneCardsi GC17P021187.
HGNCi HGNC:6843. MAP2K3.
HPAi CAB018548.
HPA044497.
MIMi 602315. gene.
neXtProti NX_P46734.
PharmGKBi PA30588.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000234206.
HOVERGENi HBG108518.
KOi K04432.
OMAi NYLELME.
PhylomeDBi P46734.
TreeFami TF350701.

Enzyme and pathway databases

BRENDAi 2.7.12.2. 2681.
Reactomei REACT_169436. Oxidative Stress Induced Senescence.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
SignaLinki P46734.

Miscellaneous databases

ChiTaRSi MAP2K3. human.
GeneWikii MAP2K3.
GenomeRNAii 5606.
NextBioi 21784.
PMAP-CutDB P46734.
PROi P46734.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46734.
Bgeei P46734.
CleanExi HS_MAP2K3.
Genevestigatori P46734.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
    Derijard B., Raingeaud J., Barrett T., Wu I.-H., Han J., Ulevitch R.J., Davis R.J.
    Science 267:682-685(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2."
    Moriguchi T., Toyoshima F., Gotoh Y., Iwamatsu A., Irie K., Mori E., Kuroyanagi N., Hagiwara M., Matsumoto K., Nishida E.
    J. Biol. Chem. 271:26981-26988(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. Han J.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 2 AND 3).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Leukocyte.
  6. "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."
    Raingeaud J., Whitmarsh A.J., Barrett T., Derijard B., Davis R.J.
    Mol. Cell. Biol. 16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-218 AND THR-222, MUTAGENESIS OF SER-218 AND THR-222.
  7. "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2."
    Chen Z., Cobb M.H.
    J. Biol. Chem. 276:16070-16075(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY TAOK2.
  8. "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha."
    Lim S., Jin K., Friedman E.
    J. Biol. Chem. 277:25040-25046(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYRK1B.
    Tissue: Muscle.
  9. "Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."
    McLaughlin N.J., Banerjee A., Kelher M.R., Gamboni-Robertson F., Hamiel C., Sheppard F.R., Moore E.E., Silliman C.C.
    J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  10. "Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation."
    Mukherjee S., Keitany G., Li Y., Wang Y., Ball H.L., Goldsmith E.J., Orth K.
    Science 312:1211-1214(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YOPJ, ACETYLATION.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mutation analyses of 268 candidate genes in human tumor cell lines."
    Teng D.-H., Chen Y., Lian L., Ha P.C., Tavtigian S.V., Wong A.K.C.
    Genomics 74:352-364(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS COLON CANCER TRP-175 AND VAL-215.
  16. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-26; PRO-68; THR-84; ILE-90; LEU-94; TRP-96; HIS-293 AND MET-339.

Entry informationi

Entry nameiMP2K3_HUMAN
AccessioniPrimary (citable) accession number: P46734
Secondary accession number(s): B3KSK7
, Q99441, Q9UE71, Q9UE72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 2002
Last modified: September 3, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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