P46725 (P5CR_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	ML2430
ORF Names:	B2168_C2_211

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Pyrroline-5-carboxylate reductase		PRO_0000187293

Sequences

	Sequence		Length	Mass (Da)
	P46725 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EA8606C9CBBB6D9D	FASTA	294	30,237
	10 20 30 40 50 60 MLSSMARIAI IGGGSIGEAL LSGLLRAGRQ VKDLVVAERM PDRARYLADT YSVLVTSVTD 70 80 90 100 110 120 AVENAMFVVV AVKPTDVESV MGDLVQAAAV ANDSAEQVLV TVAAGVTITY LESKLPAGTP 130 140 150 160 170 180 VVRAMPNAAA LVGAGVTVLA KGRFVTGQQF EDVLAMFDAV GGVLTVPESQ MDAVTAVSGS 190 200 210 220 230 240 GPAYFFLLVE ALVDAGVAVG LTRQVATELA AQTMAGSAAM LLERMDQDRH SAEVAPLGAQ 250 260 270 280 290 VDVPAAQLRA TITSPGGTTA AALRELERGG LRMVVDAAVQ AAKIRSEQLR ITSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00018 Genomic DNA. Translation: AAA17233.1. AL583925 Genomic DNA. Translation: CAC31947.1.
PIR	S72897.
RefSeq	NP_302575.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P46725.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000027960; EBMYCP00000027566; EBMYCG00000027955.
GeneID	908565.
GenomeReviews	Gene locus ML2430 in contig AL450380_GR.
KEGG	mle:ML2430.
NMPDR	fig|272631.1.peg.1447.
PATRIC	18059509. VBIMycLep78757_4669.
Organism-specific databases
Leproma	ML2430.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017740.
HOGENOM	HBG726602.
OMA	HKKYGVK.
ProtClustDB	PRK11880.
Enzyme and pathway databases
BioCyc	MLEP272631:ML2430-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_MYCLE

Accession

Primary (citable) accession number: P46725

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program