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P46723

- HEM2_MYCLE

UniProt

P46723 - HEM2_MYCLE

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Protein
Delta-aminolevulinic acid dehydratase
Gene
hemB, ML2419, B2168_C3_264
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021Schiff-base intermediate with substrate By similarity
Binding sitei212 – 2121Substrate 1 By similarity
Binding sitei223 – 2231Substrate 1 By similarity
Metal bindingi239 – 2391Magnesium By similarity
Active sitei254 – 2541Schiff-base intermediate with substrate By similarity
Binding sitei280 – 2801Substrate 2 By similarity
Binding sitei319 – 3191Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:ML2419
ORF Names:B2168_C3_264
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Delta-aminolevulinic acid dehydratase
PRO_0000140504Add
BLAST

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi272631.ML2419.

Structurei

3D structure databases

ProteinModelPortaliP46723.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiDMILTYF.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46723-1 [UniParc]FASTAAdd to Basket

« Hide

MSVSGYPRHR PRRLRSTPAM RRLVAQTSLE PRNLVLPMFV ADGIDELRPI    50
ASMPGVVQHT RDSLRRAAVA AVDAGVGGLN LFGVPRDQDK DATGSAGVDP 100
DGILNVALRD LAEDLGDATV LMADTCLDEF TDHGHCGVLD GQGRVDNDAT 150
VARYVELAVA QAESGANVVG PSGMMDGQIG ALRDGLDSAG YADVAILAYA 200
AKFSSAFYGP FREAVSCSLS GDRRTYQQEP GNAREALREI KLDLDEGADI 250
IMIKPASGYL DVVATAAGVS PVPVAAYQVS GEYAMICAAA ANNWIDERAA 300
VLESLTSIRR AGADIVFTYW AADVACWLS 329
Length:329
Mass (Da):34,775
Last modified:November 1, 1995 - v1
Checksum:i1E0EBA9498B8609C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00018 Genomic DNA. Translation: AAA17246.1.
AL583925 Genomic DNA. Translation: CAC31935.1.
PIRiS72910.
RefSeqiNP_302564.1. NC_002677.1.
WP_010908884.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31935; CAC31935; CAC31935.
GeneIDi908581.
KEGGimle:ML2419.
PATRICi18059483. VBIMycLep78757_4656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00018 Genomic DNA. Translation: AAA17246.1 .
AL583925 Genomic DNA. Translation: CAC31935.1 .
PIRi S72910.
RefSeqi NP_302564.1. NC_002677.1.
WP_010908884.1. NC_002677.1.

3D structure databases

ProteinModelPortali P46723.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31935 ; CAC31935 ; CAC31935 .
GeneIDi 908581.
KEGGi mle:ML2419.
PATRICi 18059483. VBIMycLep78757_4656.

Organism-specific databases

Lepromai ML2419.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi DMILTYF.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiHEM2_MYCLE
AccessioniPrimary (citable) accession number: P46723
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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