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P46721 (SO1A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1A2
Alternative name(s):
OATP-A
Organic anion-transporting polypeptide 1
Short name=OATP-1
Sodium-independent organic anion transporter
Solute carrier family 21 member 3
Gene names
Name:SLCO1A2
Synonyms:OATP, OATP1, OATP1A2, SLC21A3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids By similarity. Selectively inhibited by the grapefruit juice component naringin. Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform OATP1a (identifier: P46721-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform OATP1b (identifier: P46721-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
     559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
     582-670: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Solute carrier organic anion transporter family member 1A2
PRO_0000191042

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Name=1; Potential
Topological domain41 – 5919Extracellular Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 866Cytoplasmic Potential
Transmembrane87 – 11125Helical; Name=3; Potential
Topological domain112 – 15544Extracellular Potential
Transmembrane156 – 18429Helical; Name=4; Potential
Topological domain185 – 20319Cytoplasmic Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Topological domain225 – 24218Extracellular Potential
Transmembrane243 – 26725Helical; Name=6; Potential
Topological domain268 – 31144Cytoplasmic Potential
Transmembrane312 – 33322Helical; Name=7; Potential
Topological domain334 – 35320Extracellular Potential
Transmembrane354 – 37724Helical; Name=8; Potential
Topological domain378 – 3814Cytoplasmic Potential
Transmembrane382 – 40524Helical; Name=9; Potential
Topological domain406 – 513108Extracellular Potential
Transmembrane514 – 53623Helical; Name=10; Potential
Topological domain537 – 5459Cytoplasmic Potential
Transmembrane546 – 57126Helical; Name=11; Potential
Topological domain572 – 60534Extracellular Potential
Transmembrane606 – 62318Helical; Name=12; Potential
Topological domain624 – 67047Cytoplasmic Potential
Domain433 – 48856Kazal-like

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation4121N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Disulfide bond439 ↔ 465 By similarity
Disulfide bond443 ↔ 454 By similarity
Disulfide bond445 ↔ 469 By similarity

Natural variations

Alternative sequence1 – 1919MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b.
VSP_006130
Alternative sequence559 – 58123AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b.
VSP_006131
Alternative sequence582 – 67089Missing in isoform OATP1b.
VSP_006132
Natural variant131I → T. Ref.7
Corresponds to variant rs10841795 [ dbSNP | Ensembl ].
VAR_024644
Natural variant1281N → Y. Ref.7
Corresponds to variant rs11568567 [ dbSNP | Ensembl ].
VAR_020289
Natural variant1351N → I. Ref.7
Corresponds to variant rs45502302 [ dbSNP | Ensembl ].
VAR_020290
Natural variant1721E → D. Ref.7
Corresponds to variant rs11568563 [ dbSNP | Ensembl ].
VAR_020291
Natural variant1871A → T. Ref.7
VAR_036823
Natural variant2201V → I in a colorectal cancer sample; somatic mutation. Ref.8
VAR_036409
Natural variant3551I → V.
Corresponds to variant rs45628437 [ dbSNP | Ensembl ].
VAR_020292
Natural variant6681T → S. Ref.7
Corresponds to variant rs11568557 [ dbSNP | Ensembl ].
VAR_020293

Sequences

Sequence LengthMass (Da)Tools
Isoform OATP1a [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C3A740CEF1E6F129

FASTA67074,145
        10         20         30         40         50         60 
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF 

        70         80         90        100        110        120 
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS 

       130        140        150        160        170        180 
VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI 

       190        200        210        220        230        240 
SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR 

       250        260        270        280        290        300 
WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG 

       310        320        330        340        350        360 
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI 

       370        380        390        400        410        420 
YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT 

       430        440        450        460        470        480 
SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV 

       490        500        510        520        530        540 
FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK 

       550        560        570        580        590        600 
SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI 

       610        620        630        640        650        660 
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV 

       670 
LKDDELKTKL 

« Hide

Isoform OATP1b [UniParc].

Checksum: 6D80DBB0029DC66E
Show »

FASTA57964,369

References

« Hide 'large scale' references
[1]"Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver."
Kullak-Ublick G.-A., Hagenbuch B., Stieger B., Schteingart C.D., Hofmann A.F., Wolkoff A.W., Meier P.J.
Gastroenterology 109:1274-1282(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OATP1A).
Tissue: Liver.
[2]"Isolation of human neural alternative form of organic anion transporter subtype."
Abe T., Kakyo M., Yawo H.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1B).
[3]"Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
Koenig J., Cui Y., Nies A.T., Keppler D.
J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
[4]"Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes."
Speek M.
Mol. Cell. Biol. 21:1973-1985(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
Tissue: Teratocarcinoma.
[5]"Upstream region of the human organic anion transporting polypeptide A (OATP-A) gene."
Kullak-Ublick G.-A.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-20.
[6]"Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice."
Bailey D.G., Dresser G.K., Leake B.F., Kim R.B.
Clin. Pharmacol. Ther. 81:495-502(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry."
Lee W., Glaeser H., Smith L.H., Roberts R.L., Moeckel G.W., Gervasini G., Leake B.F., Kim R.B.
J. Biol. Chem. 280:9610-9617(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-13; TYR-128; ILE-135; ASP-172; THR-187 AND SER-668.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-220.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21943 mRNA. Translation: AAA87732.1.
AF085224 mRNA. Translation: AAD52694.1.
AJ400735 expand/collapse EMBL AC list , AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA. Translation: CAB97006.1.
AF279784 mRNA. Translation: AAG30037.1.
Y08062 Genomic DNA. Translation: CAB64372.1.
RefSeqNP_066580.1. NM_021094.3.
NP_602307.1. NM_134431.3.
XP_005253531.1. XM_005253474.2.
XP_005253535.1. XM_005253478.1.
UniGeneHs.46440.

3D structure databases

ProteinModelPortalP46721.
SMRP46721. Positions 442-503, 595-624.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP46721. 1 interaction.
STRING9606.ENSP00000305974.

Chemistry

ChEMBLCHEMBL1743123.
GuidetoPHARMACOLOGY1219.

Protein family/group databases

TCDB2.A.60.1.14. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteP46721.

Polymorphism databases

DMDM1171882.

Proteomic databases

PaxDbP46721.
PRIDEP46721.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307378; ENSP00000305974; ENSG00000084453. [P46721-1]
ENST00000390670; ENSP00000375088; ENSG00000084453. [P46721-2]
ENST00000452078; ENSP00000393973; ENSG00000084453. [P46721-1]
GeneID6579.
KEGGhsa:6579.
UCSCuc001rer.3. human. [P46721-1]
uc001ret.3. human. [P46721-2]

Organism-specific databases

CTD6579.
GeneCardsGC12M021417.
HGNCHGNC:10956. SLCO1A2.
HPAHPA027537.
MIM602883. gene.
neXtProtNX_P46721.
PharmGKBPA328.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256971.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidP46721.
KOK03460.
OMAQQDLYVG.
OrthoDBEOG7GFB4C.
PhylomeDBP46721.
TreeFamTF317540.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP46721.
BgeeP46721.
CleanExHS_SLCO1A2.
GenevestigatorP46721.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO1A2. human.
GeneWikiSLCO1A2.
GenomeRNAi6579.
NextBio25595.
PROP46721.
SOURCESearch...

Entry information

Entry nameSO1A2_HUMAN
AccessionPrimary (citable) accession number: P46721
Secondary accession number(s): Q9UGP7, Q9UL38
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM