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P46721

- SO1A2_HUMAN

UniProt

P46721 - SO1A2_HUMAN

Protein

Solute carrier organic anion transporter family member 1A2

Gene

SLCO1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids By similarity. Selectively inhibited by the grapefruit juice component naringin.By similarity1 Publication

    GO - Molecular functioni

    1. organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. bile acid and bile salt transport Source: Reactome
    2. bile acid metabolic process Source: Reactome
    3. organic anion transport Source: ProtInc
    4. small molecule metabolic process Source: Reactome
    5. sodium-independent organic anion transport Source: Reactome
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.14. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1A2
    Alternative name(s):
    OATP-A
    Organic anion-transporting polypeptide 1
    Short name:
    OATP-1
    Sodium-independent organic anion transporter
    Solute carrier family 21 member 3
    Gene namesi
    Name:SLCO1A2
    Synonyms:OATP, OATP1, OATP1A2, SLC21A3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10956. SLCO1A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA328.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Solute carrier organic anion transporter family member 1A2PRO_0000191042Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
    Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 469PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP46721.
    PRIDEiP46721.

    PTM databases

    PhosphoSiteiP46721.

    Expressioni

    Gene expression databases

    ArrayExpressiP46721.
    BgeeiP46721.
    CleanExiHS_SLCO1A2.
    GenevestigatoriP46721.

    Organism-specific databases

    HPAiHPA027537.

    Interactioni

    Protein-protein interaction databases

    IntActiP46721. 1 interaction.
    STRINGi9606.ENSP00000305974.

    Structurei

    3D structure databases

    ProteinModelPortaliP46721.
    SMRiP46721. Positions 443-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 866CytoplasmicSequence Analysis
    Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini378 – 3814CytoplasmicSequence Analysis
    Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 5459CytoplasmicSequence Analysis
    Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256971.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiP46721.
    KOiK03460.
    OMAiQQDLYVG.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiP46721.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform OATP1a (identifier: P46721-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ    50
    FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC 100
    FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT 150
    KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE 200
    TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL 250
    ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG 300
    ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS 350
    SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL 400
    LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW 450
    DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC 500
    DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL 550
    HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI 600
    YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE 650
    CKDIYQKSTV LKDDELKTKL 670
    Length:670
    Mass (Da):74,145
    Last modified:November 1, 1995 - v1
    Checksum:iC3A740CEF1E6F129
    GO
    Isoform OATP1b (identifier: P46721-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
         559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
         582-670: Missing.

    Show »
    Length:579
    Mass (Da):64,369
    Checksum:i6D80DBB0029DC66E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131I → T.1 Publication
    Corresponds to variant rs10841795 [ dbSNP | Ensembl ].
    VAR_024644
    Natural varianti128 – 1281N → Y.1 Publication
    Corresponds to variant rs11568567 [ dbSNP | Ensembl ].
    VAR_020289
    Natural varianti135 – 1351N → I.1 Publication
    Corresponds to variant rs45502302 [ dbSNP | Ensembl ].
    VAR_020290
    Natural varianti172 – 1721E → D.1 Publication
    Corresponds to variant rs11568563 [ dbSNP | Ensembl ].
    VAR_020291
    Natural varianti187 – 1871A → T.1 Publication
    VAR_036823
    Natural varianti220 – 2201V → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036409
    Natural varianti355 – 3551I → V.
    Corresponds to variant rs45628437 [ dbSNP | Ensembl ].
    VAR_020292
    Natural varianti668 – 6681T → S.1 Publication
    Corresponds to variant rs11568557 [ dbSNP | Ensembl ].
    VAR_020293

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b. CuratedVSP_006130Add
    BLAST
    Alternative sequencei559 – 58123AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b. CuratedVSP_006131Add
    BLAST
    Alternative sequencei582 – 67089Missing in isoform OATP1b. CuratedVSP_006132Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21943 mRNA. Translation: AAA87732.1.
    AF085224 mRNA. Translation: AAD52694.1.
    AJ400735
    , AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA. Translation: CAB97006.1.
    AF279784 mRNA. Translation: AAG30037.1.
    Y08062 Genomic DNA. Translation: CAB64372.1.
    CCDSiCCDS8686.1. [P46721-1]
    RefSeqiNP_066580.1. NM_021094.3. [P46721-1]
    NP_602307.1. NM_134431.3. [P46721-1]
    XP_005253531.1. XM_005253474.2. [P46721-1]
    XP_005253535.1. XM_005253478.1. [P46721-2]
    UniGeneiHs.46440.

    Genome annotation databases

    EnsembliENST00000307378; ENSP00000305974; ENSG00000084453. [P46721-1]
    GeneIDi6579.
    KEGGihsa:6579.
    UCSCiuc001rer.3. human. [P46721-1]
    uc001ret.3. human. [P46721-2]

    Polymorphism databases

    DMDMi1171882.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21943 mRNA. Translation: AAA87732.1 .
    AF085224 mRNA. Translation: AAD52694.1 .
    AJ400735
    , AJ400736 , AJ400737 , AJ400738 , AJ400739 , AJ400740 , AJ400741 , AJ400742 , AJ400743 , AJ400744 , AJ400745 , AJ400746 , AJ400747 , AJ400748 Genomic DNA. Translation: CAB97006.1 .
    AF279784 mRNA. Translation: AAG30037.1 .
    Y08062 Genomic DNA. Translation: CAB64372.1 .
    CCDSi CCDS8686.1. [P46721-1 ]
    RefSeqi NP_066580.1. NM_021094.3. [P46721-1 ]
    NP_602307.1. NM_134431.3. [P46721-1 ]
    XP_005253531.1. XM_005253474.2. [P46721-1 ]
    XP_005253535.1. XM_005253478.1. [P46721-2 ]
    UniGenei Hs.46440.

    3D structure databases

    ProteinModelPortali P46721.
    SMRi P46721. Positions 443-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P46721. 1 interaction.
    STRINGi 9606.ENSP00000305974.

    Chemistry

    ChEMBLi CHEMBL1743123.
    GuidetoPHARMACOLOGYi 1219.

    Protein family/group databases

    TCDBi 2.A.60.1.14. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei P46721.

    Polymorphism databases

    DMDMi 1171882.

    Proteomic databases

    PaxDbi P46721.
    PRIDEi P46721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307378 ; ENSP00000305974 ; ENSG00000084453 . [P46721-1 ]
    GeneIDi 6579.
    KEGGi hsa:6579.
    UCSCi uc001rer.3. human. [P46721-1 ]
    uc001ret.3. human. [P46721-2 ]

    Organism-specific databases

    CTDi 6579.
    GeneCardsi GC12M021417.
    HGNCi HGNC:10956. SLCO1A2.
    HPAi HPA027537.
    MIMi 602883. gene.
    neXtProti NX_P46721.
    PharmGKBi PA328.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256971.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi P46721.
    KOi K03460.
    OMAi QQDLYVG.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi P46721.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO1A2. human.
    GeneWikii SLCO1A2.
    GenomeRNAii 6579.
    NextBioi 25595.
    PROi P46721.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46721.
    Bgeei P46721.
    CleanExi HS_SLCO1A2.
    Genevestigatori P46721.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver."
      Kullak-Ublick G.-A., Hagenbuch B., Stieger B., Schteingart C.D., Hofmann A.F., Wolkoff A.W., Meier P.J.
      Gastroenterology 109:1274-1282(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OATP1A).
      Tissue: Liver.
    2. "Isolation of human neural alternative form of organic anion transporter subtype."
      Abe T., Kakyo M., Yawo H.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1B).
    3. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
      Koenig J., Cui Y., Nies A.T., Keppler D.
      J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
    4. "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes."
      Speek M.
      Mol. Cell. Biol. 21:1973-1985(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
      Tissue: Teratocarcinoma.
    5. "Upstream region of the human organic anion transporting polypeptide A (OATP-A) gene."
      Kullak-Ublick G.-A.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-20.
    6. "Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice."
      Bailey D.G., Dresser G.K., Leake B.F., Kim R.B.
      Clin. Pharmacol. Ther. 81:495-502(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry."
      Lee W., Glaeser H., Smith L.H., Roberts R.L., Moeckel G.W., Gervasini G., Leake B.F., Kim R.B.
      J. Biol. Chem. 280:9610-9617(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-13; TYR-128; ILE-135; ASP-172; THR-187 AND SER-668.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-220.

    Entry informationi

    Entry nameiSO1A2_HUMAN
    AccessioniPrimary (citable) accession number: P46721
    Secondary accession number(s): Q9UGP7, Q9UL38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3