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Protein

Solute carrier organic anion transporter family member 1A2

Gene

SLCO1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084453-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.14. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A2
Alternative name(s):
OATP-A
Organic anion-transporting polypeptide 1
Short name:
OATP-1
Sodium-independent organic anion transporter
Solute carrier family 21 member 3
Gene namesi
Name:SLCO1A2
Synonyms:OATP, OATP1, OATP1A2, SLC21A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10956. SLCO1A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 155ExtracellularSequence analysisAdd BLAST44
Transmembranei156 – 184Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini185 – 203CytoplasmicSequence analysisAdd BLAST19
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 242ExtracellularSequence analysisAdd BLAST18
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 311CytoplasmicSequence analysisAdd BLAST44
Transmembranei312 – 333Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini334 – 353ExtracellularSequence analysisAdd BLAST20
Transmembranei354 – 377Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini378 – 381CytoplasmicSequence analysis4
Transmembranei382 – 405Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini406 – 513ExtracellularSequence analysisAdd BLAST108
Transmembranei514 – 536Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini537 – 545CytoplasmicSequence analysis9
Transmembranei546 – 571Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini572 – 605ExtracellularSequence analysisAdd BLAST34
Transmembranei606 – 623Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini624 – 670CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6579.
OpenTargetsiENSG00000084453.
PharmGKBiPA328.

Chemistry databases

ChEMBLiCHEMBL1743123.
DrugBankiDB00345. Aminohippurate.
DB01076. Atorvastatin.
DB00887. Bumetanide.
DB00291. Chlorambucil.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB03619. Deoxycholic Acid.
DB01234. Dexamethasone.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00584. Enalapril.
DB00199. Erythromycin.
DB00783. Estradiol.
DB04573. Estriol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01016. Glyburide.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB06710. Methyltestosterone.
DB08893. Mirabegron.
DB01183. Naloxone.
DB00788. Naproxen.
DB00220. Nelfinavir.
DB01092. Ouabain.
DB00175. Pravastatin.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01032. Probenecid.
DB00908. Quinidine.
DB00468. Quinine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB00728. Rocuronium.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00421. Spironolactone.
DB00669. Sumatriptan.
DB08834. Tauroursodeoxycholic acid.
DB00624. Testosterone.
DB01124. Tolbutamide.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi1219.

Polymorphism and mutation databases

BioMutaiSLCO1A2.
DMDMi1171882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910421 – 670Solute carrier organic anion transporter family member 1A2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi412N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46721.
PeptideAtlasiP46721.
PRIDEiP46721.

PTM databases

iPTMnetiP46721.
PhosphoSitePlusiP46721.

Expressioni

Gene expression databases

BgeeiENSG00000084453.
CleanExiHS_SLCO1A2.
ExpressionAtlasiP46721. baseline and differential.
GenevisibleiP46721. HS.

Interactioni

Protein-protein interaction databases

IntActiP46721. 1 interactor.
STRINGi9606.ENSP00000305974.

Chemistry databases

BindingDBiP46721.

Structurei

3D structure databases

ProteinModelPortaliP46721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 488Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiP46721.
KOiK03460.
OMAiDCNCPSK.
OrthoDBiEOG091G08QD.
PhylomeDBiP46721.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform OATP1a (identifier: P46721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ
60 70 80 90 100
FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC
110 120 130 140 150
FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT
160 170 180 190 200
KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE
210 220 230 240 250
TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL
260 270 280 290 300
ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS
360 370 380 390 400
SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL
410 420 430 440 450
LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW
460 470 480 490 500
DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC
510 520 530 540 550
DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
610 620 630 640 650
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE
660 670
CKDIYQKSTV LKDDELKTKL
Length:670
Mass (Da):74,145
Last modified:November 1, 1995 - v1
Checksum:iC3A740CEF1E6F129
GO
Isoform OATP1b (identifier: P46721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
     559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
     582-670: Missing.

Show »
Length:579
Mass (Da):64,369
Checksum:i6D80DBB0029DC66E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02464413I → T.1 PublicationCorresponds to variant rs10841795dbSNPEnsembl.1
Natural variantiVAR_020289128N → Y.1 PublicationCorresponds to variant rs11568567dbSNPEnsembl.1
Natural variantiVAR_020290135N → I.1 PublicationCorresponds to variant rs45502302dbSNPEnsembl.1
Natural variantiVAR_020291172E → D.1 PublicationCorresponds to variant rs11568563dbSNPEnsembl.1
Natural variantiVAR_036823187A → T.1 PublicationCorresponds to variant rs750165758dbSNPEnsembl.1
Natural variantiVAR_036409220V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020292355I → V.Corresponds to variant rs45628437dbSNPEnsembl.1
Natural variantiVAR_020293668T → S.1 PublicationCorresponds to variant rs11568557dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0061301 – 19MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b. CuratedAdd BLAST19
Alternative sequenceiVSP_006131559 – 581AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b. CuratedAdd BLAST23
Alternative sequenceiVSP_006132582 – 670Missing in isoform OATP1b. CuratedAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21943 mRNA. Translation: AAA87732.1.
AF085224 mRNA. Translation: AAD52694.1.
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA. Translation: CAB97006.1.
AF279784 mRNA. Translation: AAG30037.1.
Y08062 Genomic DNA. Translation: CAB64372.1.
CCDSiCCDS8686.1. [P46721-1]
RefSeqiNP_066580.1. NM_021094.3. [P46721-1]
NP_602307.1. NM_134431.3. [P46721-1]
XP_005253531.1. XM_005253474.3. [P46721-1]
XP_011519120.1. XM_011520818.1. [P46721-1]
XP_011519121.1. XM_011520819.1. [P46721-1]
UniGeneiHs.46440.

Genome annotation databases

EnsembliENST00000307378; ENSP00000305974; ENSG00000084453. [P46721-1]
GeneIDi6579.
KEGGihsa:6579.
UCSCiuc001res.3. human. [P46721-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21943 mRNA. Translation: AAA87732.1.
AF085224 mRNA. Translation: AAD52694.1.
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA. Translation: CAB97006.1.
AF279784 mRNA. Translation: AAG30037.1.
Y08062 Genomic DNA. Translation: CAB64372.1.
CCDSiCCDS8686.1. [P46721-1]
RefSeqiNP_066580.1. NM_021094.3. [P46721-1]
NP_602307.1. NM_134431.3. [P46721-1]
XP_005253531.1. XM_005253474.3. [P46721-1]
XP_011519120.1. XM_011520818.1. [P46721-1]
XP_011519121.1. XM_011520819.1. [P46721-1]
UniGeneiHs.46440.

3D structure databases

ProteinModelPortaliP46721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46721. 1 interactor.
STRINGi9606.ENSP00000305974.

Chemistry databases

BindingDBiP46721.
ChEMBLiCHEMBL1743123.
DrugBankiDB00345. Aminohippurate.
DB01076. Atorvastatin.
DB00887. Bumetanide.
DB00291. Chlorambucil.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB03619. Deoxycholic Acid.
DB01234. Dexamethasone.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00584. Enalapril.
DB00199. Erythromycin.
DB00783. Estradiol.
DB04573. Estriol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01016. Glyburide.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB06710. Methyltestosterone.
DB08893. Mirabegron.
DB01183. Naloxone.
DB00788. Naproxen.
DB00220. Nelfinavir.
DB01092. Ouabain.
DB00175. Pravastatin.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01032. Probenecid.
DB00908. Quinidine.
DB00468. Quinine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB00728. Rocuronium.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00421. Spironolactone.
DB00669. Sumatriptan.
DB08834. Tauroursodeoxycholic acid.
DB00624. Testosterone.
DB01124. Tolbutamide.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi1219.

Protein family/group databases

TCDBi2.A.60.1.14. the organo anion transporter (oat) family.

PTM databases

iPTMnetiP46721.
PhosphoSitePlusiP46721.

Polymorphism and mutation databases

BioMutaiSLCO1A2.
DMDMi1171882.

Proteomic databases

PaxDbiP46721.
PeptideAtlasiP46721.
PRIDEiP46721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307378; ENSP00000305974; ENSG00000084453. [P46721-1]
GeneIDi6579.
KEGGihsa:6579.
UCSCiuc001res.3. human. [P46721-1]

Organism-specific databases

CTDi6579.
DisGeNETi6579.
GeneCardsiSLCO1A2.
HGNCiHGNC:10956. SLCO1A2.
MIMi602883. gene.
neXtProtiNX_P46721.
OpenTargetsiENSG00000084453.
PharmGKBiPA328.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiP46721.
KOiK03460.
OMAiDCNCPSK.
OrthoDBiEOG091G08QD.
PhylomeDBiP46721.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084453-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSLCO1A2. human.
GeneWikiiSLCO1A2.
GenomeRNAii6579.
PROiP46721.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084453.
CleanExiHS_SLCO1A2.
ExpressionAtlasiP46721. baseline and differential.
GenevisibleiP46721. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1A2_HUMAN
AccessioniPrimary (citable) accession number: P46721
Secondary accession number(s): Q9UGP7, Q9UL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.