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P46721

- SO1A2_HUMAN

UniProt

P46721 - SO1A2_HUMAN

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Protein

Solute carrier organic anion transporter family member 1A2

Gene

SLCO1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids By similarity. Selectively inhibited by the grapefruit juice component naringin.By similarity1 Publication

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. bile acid and bile salt transport Source: Reactome
  2. bile acid metabolic process Source: Reactome
  3. organic anion transport Source: ProtInc
  4. small molecule metabolic process Source: Reactome
  5. sodium-independent organic anion transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.14. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A2
Alternative name(s):
OATP-A
Organic anion-transporting polypeptide 1
Short name:
OATP-1
Sodium-independent organic anion transporter
Solute carrier family 21 member 3
Gene namesi
Name:SLCO1A2
Synonyms:OATP, OATP1, OATP1A2, SLC21A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10956. SLCO1A2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A2PRO_0000191042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46721.
PRIDEiP46721.

PTM databases

PhosphoSiteiP46721.

Expressioni

Gene expression databases

BgeeiP46721.
CleanExiHS_SLCO1A2.
ExpressionAtlasiP46721. baseline and differential.
GenevestigatoriP46721.

Organism-specific databases

HPAiHPA027537.

Interactioni

Protein-protein interaction databases

IntActiP46721. 1 interaction.
STRINGi9606.ENSP00000305974.

Structurei

3D structure databases

ProteinModelPortaliP46721.
SMRiP46721. Positions 443-471.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence Analysis
Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
BLAST
Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
BLAST
Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini378 – 3814CytoplasmicSequence Analysis
Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
BLAST
Topological domaini537 – 5459CytoplasmicSequence Analysis
Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
BLAST
Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiP46721.
KOiK03460.
OMAiQQDLYVG.
OrthoDBiEOG7GFB4C.
PhylomeDBiP46721.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform OATP1a (identifier: P46721-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ
60 70 80 90 100
FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC
110 120 130 140 150
FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT
160 170 180 190 200
KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE
210 220 230 240 250
TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL
260 270 280 290 300
ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS
360 370 380 390 400
SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL
410 420 430 440 450
LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW
460 470 480 490 500
DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC
510 520 530 540 550
DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
610 620 630 640 650
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE
660 670
CKDIYQKSTV LKDDELKTKL
Length:670
Mass (Da):74,145
Last modified:November 1, 1995 - v1
Checksum:iC3A740CEF1E6F129
GO
Isoform OATP1b (identifier: P46721-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
     559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
     582-670: Missing.

Show »
Length:579
Mass (Da):64,369
Checksum:i6D80DBB0029DC66E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131I → T.1 Publication
Corresponds to variant rs10841795 [ dbSNP | Ensembl ].
VAR_024644
Natural varianti128 – 1281N → Y.1 Publication
Corresponds to variant rs11568567 [ dbSNP | Ensembl ].
VAR_020289
Natural varianti135 – 1351N → I.1 Publication
Corresponds to variant rs45502302 [ dbSNP | Ensembl ].
VAR_020290
Natural varianti172 – 1721E → D.1 Publication
Corresponds to variant rs11568563 [ dbSNP | Ensembl ].
VAR_020291
Natural varianti187 – 1871A → T.1 Publication
VAR_036823
Natural varianti220 – 2201V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036409
Natural varianti355 – 3551I → V.
Corresponds to variant rs45628437 [ dbSNP | Ensembl ].
VAR_020292
Natural varianti668 – 6681T → S.1 Publication
Corresponds to variant rs11568557 [ dbSNP | Ensembl ].
VAR_020293

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b. CuratedVSP_006130Add
BLAST
Alternative sequencei559 – 58123AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b. CuratedVSP_006131Add
BLAST
Alternative sequencei582 – 67089Missing in isoform OATP1b. CuratedVSP_006132Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21943 mRNA. Translation: AAA87732.1.
AF085224 mRNA. Translation: AAD52694.1.
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA. Translation: CAB97006.1.
AF279784 mRNA. Translation: AAG30037.1.
Y08062 Genomic DNA. Translation: CAB64372.1.
CCDSiCCDS8686.1. [P46721-1]
RefSeqiNP_066580.1. NM_021094.3. [P46721-1]
NP_602307.1. NM_134431.3. [P46721-1]
XP_005253531.1. XM_005253474.2. [P46721-1]
XP_005253535.1. XM_005253478.1. [P46721-2]
UniGeneiHs.46440.

Genome annotation databases

EnsembliENST00000307378; ENSP00000305974; ENSG00000084453. [P46721-1]
GeneIDi6579.
KEGGihsa:6579.
UCSCiuc001rer.3. human. [P46721-1]
uc001ret.3. human. [P46721-2]

Polymorphism databases

DMDMi1171882.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21943 mRNA. Translation: AAA87732.1 .
AF085224 mRNA. Translation: AAD52694.1 .
AJ400735
, AJ400736 , AJ400737 , AJ400738 , AJ400739 , AJ400740 , AJ400741 , AJ400742 , AJ400743 , AJ400744 , AJ400745 , AJ400746 , AJ400747 , AJ400748 Genomic DNA. Translation: CAB97006.1 .
AF279784 mRNA. Translation: AAG30037.1 .
Y08062 Genomic DNA. Translation: CAB64372.1 .
CCDSi CCDS8686.1. [P46721-1 ]
RefSeqi NP_066580.1. NM_021094.3. [P46721-1 ]
NP_602307.1. NM_134431.3. [P46721-1 ]
XP_005253531.1. XM_005253474.2. [P46721-1 ]
XP_005253535.1. XM_005253478.1. [P46721-2 ]
UniGenei Hs.46440.

3D structure databases

ProteinModelPortali P46721.
SMRi P46721. Positions 443-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P46721. 1 interaction.
STRINGi 9606.ENSP00000305974.

Chemistry

ChEMBLi CHEMBL1743123.
DrugBanki DB00345. Aminohippurate.
DB01076. Atorvastatin.
DB00887. Bumetanide.
DB00291. Chlorambucil.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB01234. Dexamethasone.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00584. Enalapril.
DB00199. Erythromycin.
DB00783. Estradiol.
DB04573. Estriol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01016. Glyburide.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB00224. Indinavir.
DB00328. Indomethacin.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB06710. Methyltestosterone.
DB08893. Mirabegron.
DB01183. Naloxone.
DB00788. Naproxen.
DB00220. Nelfinavir.
DB01092. Ouabain.
DB00175. Pravastatin.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01032. Probenecid.
DB00908. Quinidine.
DB00468. Quinine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB00728. Rocuronium.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00421. Spironolactone.
DB00669. Sumatriptan.
DB08834. Tauroursodeoxycholic acid.
DB00624. Testosterone.
DB01124. Tolbutamide.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi 1219.

Protein family/group databases

TCDBi 2.A.60.1.14. the organo anion transporter (oat) family.

PTM databases

PhosphoSitei P46721.

Polymorphism databases

DMDMi 1171882.

Proteomic databases

PaxDbi P46721.
PRIDEi P46721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307378 ; ENSP00000305974 ; ENSG00000084453 . [P46721-1 ]
GeneIDi 6579.
KEGGi hsa:6579.
UCSCi uc001rer.3. human. [P46721-1 ]
uc001ret.3. human. [P46721-2 ]

Organism-specific databases

CTDi 6579.
GeneCardsi GC12M021417.
HGNCi HGNC:10956. SLCO1A2.
HPAi HPA027537.
MIMi 602883. gene.
neXtProti NX_P46721.
PharmGKBi PA328.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256971.
GeneTreei ENSGT00760000119014.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi P46721.
KOi K03460.
OMAi QQDLYVG.
OrthoDBi EOG7GFB4C.
PhylomeDBi P46721.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Miscellaneous databases

ChiTaRSi SLCO1A2. human.
GeneWikii SLCO1A2.
GenomeRNAii 6579.
NextBioi 25595.
PROi P46721.
SOURCEi Search...

Gene expression databases

Bgeei P46721.
CleanExi HS_SLCO1A2.
ExpressionAtlasi P46721. baseline and differential.
Genevestigatori P46721.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver."
    Kullak-Ublick G.-A., Hagenbuch B., Stieger B., Schteingart C.D., Hofmann A.F., Wolkoff A.W., Meier P.J.
    Gastroenterology 109:1274-1282(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OATP1A).
    Tissue: Liver.
  2. "Isolation of human neural alternative form of organic anion transporter subtype."
    Abe T., Kakyo M., Yawo H.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1B).
  3. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
    Koenig J., Cui Y., Nies A.T., Keppler D.
    J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
  4. "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes."
    Speek M.
    Mol. Cell. Biol. 21:1973-1985(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
    Tissue: Teratocarcinoma.
  5. "Upstream region of the human organic anion transporting polypeptide A (OATP-A) gene."
    Kullak-Ublick G.-A.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-20.
  6. "Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice."
    Bailey D.G., Dresser G.K., Leake B.F., Kim R.B.
    Clin. Pharmacol. Ther. 81:495-502(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry."
    Lee W., Glaeser H., Smith L.H., Roberts R.L., Moeckel G.W., Gervasini G., Leake B.F., Kim R.B.
    J. Biol. Chem. 280:9610-9617(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-13; TYR-128; ILE-135; ASP-172; THR-187 AND SER-668.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-220.

Entry informationi

Entry nameiSO1A2_HUMAN
AccessioniPrimary (citable) accession number: P46721
Secondary accession number(s): Q9UGP7, Q9UL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3