Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Programmed cell death protein 2

Gene

Pdcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger protein Rp-8
Gene namesi
Name:Pdcd2
Synonyms:Rp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104643. Pdcd2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183051 – 343Programmed cell death protein 2Add BLAST343

Post-translational modificationi

Ubiquitinated by PRKN, promoting proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP46718.
MaxQBiP46718.
PaxDbiP46718.
PeptideAtlasiP46718.
PRIDEiP46718.

PTM databases

PhosphoSitePlusiP46718.

Expressioni

Developmental stagei

Expressed during apoptosis of lymphoid and myeloid cells.

Gene expression databases

BgeeiENSMUSG00000014771.
CleanExiMM_PDCD2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052523.

Structurei

3D structure databases

ProteinModelPortaliP46718.
SMRiP46718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP46718.
KOiK14801.
PhylomeDBiP46718.
TreeFamiTF313722.

Family and domain databases

InterProiView protein in InterPro
IPR007320. PDCD2_C.
IPR002893. Znf_MYND.
PfamiView protein in Pfam
PF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPGPVE LGFAEEAPAW RLRSEQFPSK VGGRPAWLGL AELPGPGALA
60 70 80 90 100
CARCGRPLAF LLQVYAPLPG RDDAFHRSLF LFCCREPLCC AGLRVFRNQL
110 120 130 140 150
PRNNAFYSYE PPSETEALGT ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ
160 170 180 190 200
AHYCSKEHQT LDWRLGHKQA CTQSDKIDHM VPDHNFLFPE FEIVTETEDE
210 220 230 240 250
ILPEVVEMED YSEVTGSMGG IPEEELDSMA KHESKEDHIF QKFKSKIALE
260 270 280 290 300
PEQILRYGRG IKPIWISGEN IPQEKDIPDC PCGAKRIFEF QVMPQLLNHL
310 320 330 340
KADRLGRSID WGVLAVFTCA ESCSLGSGYT EEFVWKQDVT DTP
Length:343
Mass (Da):38,342
Last modified:May 10, 2004 - v2
Checksum:i6D67243B0EA16BAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88L → P in BAC32560 (PubMed:16141072).Curated1
Sequence conflicti248A → P in AAA83433 (PubMed:7880439).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10903 mRNA. Translation: AAA83433.1.
AK045985 mRNA. Translation: BAC32560.1.
CCDSiCCDS28413.1.
PIRiI49067.
RefSeqiNP_032825.2. NM_008799.2.
UniGeneiMm.323.

Genome annotation databases

GeneIDi18567.
KEGGimmu:18567.
UCSCiuc008aoq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10903 mRNA. Translation: AAA83433.1.
AK045985 mRNA. Translation: BAC32560.1.
CCDSiCCDS28413.1.
PIRiI49067.
RefSeqiNP_032825.2. NM_008799.2.
UniGeneiMm.323.

3D structure databases

ProteinModelPortaliP46718.
SMRiP46718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052523.

PTM databases

PhosphoSitePlusiP46718.

Proteomic databases

EPDiP46718.
MaxQBiP46718.
PaxDbiP46718.
PeptideAtlasiP46718.
PRIDEiP46718.

Protocols and materials databases

DNASUi18567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18567.
KEGGimmu:18567.
UCSCiuc008aoq.1. mouse.

Organism-specific databases

CTDi5134.
MGIiMGI:104643. Pdcd2.

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP46718.
KOiK14801.
PhylomeDBiP46718.
TreeFamiTF313722.

Miscellaneous databases

PROiPR:P46718.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014771.
CleanExiMM_PDCD2.

Family and domain databases

InterProiView protein in InterPro
IPR007320. PDCD2_C.
IPR002893. Znf_MYND.
PfamiView protein in Pfam
PF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD2_MOUSE
AccessioniPrimary (citable) accession number: P46718
Secondary accession number(s): Q8BR06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 10, 2004
Last modified: May 10, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.