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Protein

Programmed cell death protein 2

Gene

Pdcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 17138MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger protein Rp-8
Gene namesi
Name:Pdcd2
Synonyms:Rp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104643. Pdcd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Programmed cell death protein 2PRO_0000218305Add
BLAST

Post-translational modificationi

Ubiquitinated by PARK2, promoting proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP46718.
MaxQBiP46718.
PaxDbiP46718.
PeptideAtlasiP46718.
PRIDEiP46718.

PTM databases

PhosphoSiteiP46718.

Expressioni

Developmental stagei

Expressed during apoptosis of lymphoid and myeloid cells.

Gene expression databases

BgeeiENSMUSG00000014771.
CleanExiMM_PDCD2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052523.

Structurei

3D structure databases

ProteinModelPortaliP46718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 17138MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP46718.
KOiK14801.
PhylomeDBiP46718.
TreeFamiTF313722.

Family and domain databases

InterProiIPR007320. PDCD2_C.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPGPVE LGFAEEAPAW RLRSEQFPSK VGGRPAWLGL AELPGPGALA
60 70 80 90 100
CARCGRPLAF LLQVYAPLPG RDDAFHRSLF LFCCREPLCC AGLRVFRNQL
110 120 130 140 150
PRNNAFYSYE PPSETEALGT ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ
160 170 180 190 200
AHYCSKEHQT LDWRLGHKQA CTQSDKIDHM VPDHNFLFPE FEIVTETEDE
210 220 230 240 250
ILPEVVEMED YSEVTGSMGG IPEEELDSMA KHESKEDHIF QKFKSKIALE
260 270 280 290 300
PEQILRYGRG IKPIWISGEN IPQEKDIPDC PCGAKRIFEF QVMPQLLNHL
310 320 330 340
KADRLGRSID WGVLAVFTCA ESCSLGSGYT EEFVWKQDVT DTP
Length:343
Mass (Da):38,342
Last modified:May 10, 2004 - v2
Checksum:i6D67243B0EA16BAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881L → P in BAC32560 (PubMed:16141072).Curated
Sequence conflicti248 – 2481A → P in AAA83433 (PubMed:7880439).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10903 mRNA. Translation: AAA83433.1.
AK045985 mRNA. Translation: BAC32560.1.
CCDSiCCDS28413.1.
PIRiI49067.
RefSeqiNP_032825.2. NM_008799.2.
UniGeneiMm.323.

Genome annotation databases

GeneIDi18567.
KEGGimmu:18567.
UCSCiuc008aoq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10903 mRNA. Translation: AAA83433.1.
AK045985 mRNA. Translation: BAC32560.1.
CCDSiCCDS28413.1.
PIRiI49067.
RefSeqiNP_032825.2. NM_008799.2.
UniGeneiMm.323.

3D structure databases

ProteinModelPortaliP46718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052523.

PTM databases

PhosphoSiteiP46718.

Proteomic databases

EPDiP46718.
MaxQBiP46718.
PaxDbiP46718.
PeptideAtlasiP46718.
PRIDEiP46718.

Protocols and materials databases

DNASUi18567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18567.
KEGGimmu:18567.
UCSCiuc008aoq.1. mouse.

Organism-specific databases

CTDi5134.
MGIiMGI:104643. Pdcd2.

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP46718.
KOiK14801.
PhylomeDBiP46718.
TreeFamiTF313722.

Miscellaneous databases

PROiP46718.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014771.
CleanExiMM_PDCD2.

Family and domain databases

InterProiIPR007320. PDCD2_C.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD2_MOUSE
AccessioniPrimary (citable) accession number: P46718
Secondary accession number(s): Q8BR06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.