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Protein

Programmed cell death protein 2

Gene

Pdcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger protein Rp-8
Gene namesi
Name:Pdcd2
Synonyms:Rp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104643. Pdcd2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183051 – 343Programmed cell death protein 2Add BLAST343

Post-translational modificationi

Ubiquitinated by PRKN, promoting proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP46718.
MaxQBiP46718.
PaxDbiP46718.
PeptideAtlasiP46718.
PRIDEiP46718.

PTM databases

PhosphoSitePlusiP46718.

Expressioni

Developmental stagei

Expressed during apoptosis of lymphoid and myeloid cells.

Gene expression databases

CleanExiMM_PDCD2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052523.

Structurei

3D structure databases

ProteinModelPortaliP46718.
SMRiP46718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP46718.
KOiK14801.
PhylomeDBiP46718.
TreeFamiTF313722.

Family and domain databases

Gene3Di2.30.320.10. 1 hit.
InterProiView protein in InterPro
IPR007320. PDCD2_C.
IPR035948. YwqG-like_sf.
IPR002893. Znf_MYND.
PfamiView protein in Pfam
PF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPGPVE LGFAEEAPAW RLRSEQFPSK VGGRPAWLGL AELPGPGALA
60 70 80 90 100
CARCGRPLAF LLQVYAPLPG RDDAFHRSLF LFCCREPLCC AGLRVFRNQL
110 120 130 140 150
PRNNAFYSYE PPSETEALGT ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ
160 170 180 190 200
AHYCSKEHQT LDWRLGHKQA CTQSDKIDHM VPDHNFLFPE FEIVTETEDE
210 220 230 240 250
ILPEVVEMED YSEVTGSMGG IPEEELDSMA KHESKEDHIF QKFKSKIALE
260 270 280 290 300
PEQILRYGRG IKPIWISGEN IPQEKDIPDC PCGAKRIFEF QVMPQLLNHL
310 320 330 340
KADRLGRSID WGVLAVFTCA ESCSLGSGYT EEFVWKQDVT DTP
Length:343
Mass (Da):38,342
Last modified:May 10, 2004 - v2
Checksum:i6D67243B0EA16BAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88L → P in BAC32560 (PubMed:16141072).Curated1
Sequence conflicti248A → P in AAA83433 (PubMed:7880439).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10903 mRNA. Translation: AAA83433.1.
AK045985 mRNA. Translation: BAC32560.1.
CCDSiCCDS28413.1.
PIRiI49067.
RefSeqiNP_032825.2. NM_008799.2.
UniGeneiMm.323.

Genome annotation databases

GeneIDi18567.
KEGGimmu:18567.
UCSCiuc008aoq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPDCD2_MOUSE
AccessioniPrimary (citable) accession number: P46718
Secondary accession number(s): Q8BR06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 10, 2004
Last modified: October 25, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot