Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46716

- GSA_MYCLE

UniProt

P46716 - GSA_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Synonyms:gsa
Ordered Locus Names:ML2414
ORF Names:B2168_C1_190
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2414.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML2414.

Structurei

3D structure databases

ProteinModelPortaliP46716.
SMRiP46716. Positions 17-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46716-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSTDQATAP AGPAVSISAK LFEDACAVIP GGVNSPVRAF SAVGGTPLFI
60 70 80 90 100
TEARGCWLTD ADGRRYVDLV CSWGPMILGH AHPAVVDAVA TVAASGLSFG
110 120 130 140 150
APTPAETQLA AEIIGRMAPV ERIRLVNSGT EATMSAVRLA RGFTGRTKII
160 170 180 190 200
KFSGCYHGHV DALLADAGSG VATLSLPSSP GVTGAAAADT IVLPYNDIEA
210 220 230 240 250
VRQTFARLGD QIAAVITEAS PGNMGVVPPA PGYNAALRAI TAEHGALLII
260 270 280 290 300
DEVMTGFRVS RSGWYGLDPV AADLFIFGKV MSGGMPAAAF GGRAEVMERL
310 320 330 340 350
APLGPVYQAG TLSGNPVAMA AGLATLRAAA DAVYATLDRN ADRLVAMLSE
360 370 380 390 400
ALTDAGVPHQ IPRAGNMFSV FFSEAPVTDF ASACNSQVWR YPAFFHALLD
410 420 430 440
AGVYPPCSTF EAWFVSAALD DAAFGRIVDA LPGAAAAAVA ARHRES
Length:446
Mass (Da):45,790
Last modified:November 1, 1995 - v1
Checksum:i1C684412C451FF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17225.1.
AL583925 Genomic DNA. Translation: CAC31930.1.
PIRiS72889.
RefSeqiNP_302563.1. NC_002677.1.
WP_010908883.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31930; CAC31930; CAC31930.
GeneIDi908589.
KEGGimle:ML2414.
PATRICi18059451. VBIMycLep78757_4640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17225.1 .
AL583925 Genomic DNA. Translation: CAC31930.1 .
PIRi S72889.
RefSeqi NP_302563.1. NC_002677.1.
WP_010908883.1. NC_002677.1.

3D structure databases

ProteinModelPortali P46716.
SMRi P46716. Positions 17-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31930 ; CAC31930 ; CAC31930 .
GeneIDi 908589.
KEGGi mle:ML2414.
PATRICi 18059451. VBIMycLep78757_4640.

Organism-specific databases

Lepromai ML2414.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGSA_MYCLE
AccessioniPrimary (citable) accession number: P46716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3