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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

nadC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the catabolism of quinolinic acid (QA).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041SubstrateBy similarity
Binding sitei161 – 1611SubstrateBy similarity
Binding sitei171 – 1711SubstrateBy similarity
Binding sitei200 – 2001SubstrateBy similarity
Binding sitei221 – 2211SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00331.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Gene namesi
Name:nadC
Ordered Locus Names:ML1227
ORF Names:B1170_C1_168
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Nicotinate-nucleotide pyrophosphorylase [carboxylating]PRO_0000155945Add
BLAST

Interactioni

Subunit structurei

Hexamer formed by 3 homodimers.By similarity

Protein-protein interaction databases

STRINGi272631.ML1227.

Structurei

3D structure databases

ProteinModelPortaliP46714.
SMRiP46714. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1393Substrate bindingBy similarity
Regioni247 – 2493Substrate bindingBy similarity
Regioni268 – 2703Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

eggNOGiENOG4105D18. Bacteria.
COG0157. LUCA.
HOGENOMiHOG000224022.
OrthoDBiPOG091H05QJ.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.

Sequencei

Sequence statusi: Complete.

P46714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDCEFDAA RDTIRRALHE DLRYGLDITT QATVPAGTVV TGSMVPREPG
60 70 80 90 100
VIAGVDVALL VLDEVFGVDG YRVLYRVEDG ARLQSGQPLL TVQAAARGLL
110 120 130 140 150
TAERTMLNLV CHMSGIATVT VAWVDAVRGT KAKIRDTRKT LPGLRALQKY
160 170 180 190 200
AVRVGGGVNH RLGLGDTALI KDNHVAAVGS VVDALRAVRA AAPELPCEVE
210 220 230 240 250
VDSLEQLDAM LAEEPELILL DNFPVWQTQV AVQRRDIRAP TVLLESSGGL
260 270 280
SLENAAIYAG TGVDYLAVGA LTHSVRILDI GLDL
Length:284
Mass (Da):30,308
Last modified:November 1, 1995 - v1
Checksum:iD2EE754D8759933B
GO

Sequence cautioni

The sequence CAC31608 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00010 Genomic DNA. Translation: AAA17060.1.
AL583921 Genomic DNA. Translation: CAC31608.1. Different initiation.
PIRiE87062.
S72696.
RefSeqiWP_010908210.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31608; CAC31608; CAC31608.
PATRICi18054620. VBIMycLep78757_2250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00010 Genomic DNA. Translation: AAA17060.1.
AL583921 Genomic DNA. Translation: CAC31608.1. Different initiation.
PIRiE87062.
S72696.
RefSeqiWP_010908210.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46714.
SMRiP46714. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31608; CAC31608; CAC31608.
PATRICi18054620. VBIMycLep78757_2250.

Organism-specific databases

LepromaiML1227.

Phylogenomic databases

eggNOGiENOG4105D18. Bacteria.
COG0157. LUCA.
HOGENOMiHOG000224022.
OrthoDBiPOG091H05QJ.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00331.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADC_MYCLE
AccessioniPrimary (citable) accession number: P46714
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.