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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Binding sitei126 – 1261SubstrateBy similarity
Binding sitei166 – 1661SubstrateBy similarity
Binding sitei216 – 2161ATPBy similarity
Binding sitei304 – 3041ATP; via carbonyl oxygenBy similarity
Binding sitei335 – 3351ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi364 – 3674ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:ML0571
ORF Names:B1496_C2_162
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0571.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinasePRO_0000145967Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0571.

Structurei

3D structure databases

ProteinModelPortaliP46712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIPNLKDLL EEGVSGRCVL VRCDLNVPLG DDGAITDLGR VTASVPTLKA
60 70 80 90 100
LLEAGAKIVV AAHLGRPKNG PDPKLSLEPV AAALGEQLGQ NVQLVCSTDR
110 120 130 140 150
SPVGGDALAC VERLTDGDLL LLQNIRFDPR ETSKVDDERL ALAKQLVELV
160 170 180 190 200
GSAGAFVSDG FGVVHRRQAS VYDVATLLPH YAGILVADEI RILEQLTSSA
210 220 230 240 250
KRPYAVVLGG SKVSDKLGVI ESLATKADSI VLGGGMCFTF LAAQGFSVGK
260 270 280 290 300
SLLETEMIET CRSLLDTYAD VLRLPMDIVV TEKFVADSPP QTVAADAIPD
310 320 330 340 350
GLMGLDIGPE SVKRFATLLS NASTIFWNGP MGVFEFPAYA AGTRGVAEAI
360 370 380 390 400
VAVTGKGAFS VVGGGDSAAA MRALSLPEGS VSHLSTGGGA SLEYLEGKTL
410
PGIEVLGREQ PRGGDS
Length:416
Mass (Da):43,279
Last modified:November 1, 1995 - v1
Checksum:i559BAE226C9D2E53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17121.1.
AL583919 Genomic DNA. Translation: CAC30079.1.
PIRiS72781.
RefSeqiNP_301483.1. NC_002677.1.
WP_010907807.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30079; CAC30079; CAC30079.
GeneIDi909304.
KEGGimle:ML0571.
PATRICi18052104. VBIMycLep78757_0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17121.1.
AL583919 Genomic DNA. Translation: CAC30079.1.
PIRiS72781.
RefSeqiNP_301483.1. NC_002677.1.
WP_010907807.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0571.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30079; CAC30079; CAC30079.
GeneIDi909304.
KEGGimle:ML0571.
PATRICi18052104. VBIMycLep78757_0999.

Organism-specific databases

LepromaiML0571.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPGK_MYCLE
AccessioniPrimary (citable) accession number: P46712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.