P46712 (PGK_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	ML0571
ORF Names:	B1496_C2_162

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Phosphoglycerate kinase HAMAP MF_00145		PRO_0000145967
Regions
	Nucleotide binding	364 – 367	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	63 – 66	4	Substrate binding By similarity
Sites
	Binding site	40	1	Substrate By similarity
	Binding site	126	1	Substrate By similarity
	Binding site	166	1	Substrate By similarity
	Binding site	216	1	ATP By similarity
	Binding site	304	1	ATP; via carbonyl oxygen By similarity
	Binding site	335	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46712 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 559BAE226C9D2E53	FASTA	416	43,279
	10 20 30 40 50 60 MRIPNLKDLL EEGVSGRCVL VRCDLNVPLG DDGAITDLGR VTASVPTLKA LLEAGAKIVV 70 80 90 100 110 120 AAHLGRPKNG PDPKLSLEPV AAALGEQLGQ NVQLVCSTDR SPVGGDALAC VERLTDGDLL 130 140 150 160 170 180 LLQNIRFDPR ETSKVDDERL ALAKQLVELV GSAGAFVSDG FGVVHRRQAS VYDVATLLPH 190 200 210 220 230 240 YAGILVADEI RILEQLTSSA KRPYAVVLGG SKVSDKLGVI ESLATKADSI VLGGGMCFTF 250 260 270 280 290 300 LAAQGFSVGK SLLETEMIET CRSLLDTYAD VLRLPMDIVV TEKFVADSPP QTVAADAIPD 310 320 330 340 350 360 GLMGLDIGPE SVKRFATLLS NASTIFWNGP MGVFEFPAYA AGTRGVAEAI VAVTGKGAFS 370 380 390 400 410 VVGGGDSAAA MRALSLPEGS VSHLSTGGGA SLEYLEGKTL PGIEVLGREQ PRGGDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00013 Genomic DNA. Translation: AAA17121.1. AL583919 Genomic DNA. Translation: CAC30079.1.
PIR	S72781.
RefSeq	NP_301483.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P46712.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000028258; EBMYCP00000027864; EBMYCG00000028253.
GeneID	909304.
GenomeReviews	Gene locus ML0571 in contig AL450380_GR.
KEGG	mle:ML0571.
NMPDR	fig|272631.1.peg.355.
PATRIC	18052104. VBIMycLep78757_0999.
Organism-specific databases
Leproma	ML0571.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017271.
HOGENOM	HBG453500.
OMA	QDETRIL.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0571-MONOMER.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KO	K00927.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_MYCLE

Accession

Primary (citable) accession number: P46712

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program