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P46712 (PGK_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:ML0571
ORF Names:B1496_C2_162
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145967

Regions

Nucleotide binding364 – 3674ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1261Substrate By similarity
Binding site1661Substrate By similarity
Binding site2161ATP By similarity
Binding site3041ATP; via carbonyl oxygen By similarity
Binding site3351ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P46712 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 559BAE226C9D2E53

FASTA41643,279
        10         20         30         40         50         60 
MRIPNLKDLL EEGVSGRCVL VRCDLNVPLG DDGAITDLGR VTASVPTLKA LLEAGAKIVV 

        70         80         90        100        110        120 
AAHLGRPKNG PDPKLSLEPV AAALGEQLGQ NVQLVCSTDR SPVGGDALAC VERLTDGDLL 

       130        140        150        160        170        180 
LLQNIRFDPR ETSKVDDERL ALAKQLVELV GSAGAFVSDG FGVVHRRQAS VYDVATLLPH 

       190        200        210        220        230        240 
YAGILVADEI RILEQLTSSA KRPYAVVLGG SKVSDKLGVI ESLATKADSI VLGGGMCFTF 

       250        260        270        280        290        300 
LAAQGFSVGK SLLETEMIET CRSLLDTYAD VLRLPMDIVV TEKFVADSPP QTVAADAIPD 

       310        320        330        340        350        360 
GLMGLDIGPE SVKRFATLLS NASTIFWNGP MGVFEFPAYA AGTRGVAEAI VAVTGKGAFS 

       370        380        390        400        410 
VVGGGDSAAA MRALSLPEGS VSHLSTGGGA SLEYLEGKTL PGIEVLGREQ PRGGDS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00013 Genomic DNA. Translation: AAA17121.1.
AL583919 Genomic DNA. Translation: CAC30079.1.
PIRS72781.
RefSeqNP_301483.1. NC_002677.1.

3D structure databases

ProteinModelPortalP46712.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30079; CAC30079; CAC30079.
GeneID909304.
KEGGmle:ML0571.
PATRIC18052104. VBIMycLep78757_0999.

Organism-specific databases

LepromaML0571.
CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAGLDCGEK.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCLE
AccessionPrimary (citable) accession number: P46712
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways