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P46710

- CAPP_MYCLE

UniProt

P46710 - CAPP_MYCLE

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, ML0578, B1496_C3_207
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611 By similarity
Active sitei593 – 5931 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:ML0578
ORF Names:B1496_C3_207
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000166600Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0578.

Structurei

3D structure databases

ProteinModelPortaliP46710.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiELSTISC.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46710-1 [UniParc]FASTAAdd to Basket

« Hide

MVEFSDAILE PIGAVQRTRV GREATEPMRA DIRLLGTILG DTLREQNGDE    50
VFDLVERVRV ESFRVRRSEI DRADMARMFS GLDIHLAIPI IRAFSHFALL 100
ANVAEDIHRE RRRHIHLDAG EPLRDSSLAA TYAKLDLAKL DSATVADALT 150
GAVVSPVITA HPTETRRRTV FVTQRRITEL MRLHAEGHTE TADGRSIERE 200
LRRQILTLWQ TALIRLARLQ ISDEIDVGLR YYSAALFHVI PQVNSEVRNA 250
LRARWPDAEL LSGPILQPGS WIGGDRDGNP NVTADVVRRA TGSAAYTVVA 300
HYLAELTHLE QELSMSARLI TVTPELATLA ASCQDAACAD EPYRRALRVI 350
RGRLSSTAAH ILDQQPPNQL GLGLPPYSTP AELCADLDTI EASLCTHGAA 400
LLADDRLALL REGVGVFGFH LCGLDMRQNS DVHEEVVAEL LAWAGMHQDY 450
SSLPEDQRVK LLVAELGNRR PLVGDRAQLS DLARGELAVL AAAAHAVELY 500
GSAAVPNYII SMCQSVSDVL EVAILLKETG LLDASGSQPY CPVGISPLFE 550
TIDDLHNGAA ILHAMLELPL YRTLVAARGN WQEVMLGYSD SNKDGGYLAA 600
NWAVYRAELA LVDVARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA 650
VNGSLRLTEQ GEVIAAKYAE PQIARRNLES LVAATLESTL LDVEGLGDAA 700
ESAYAILDEV AGLARRSYAE LVNTPGFVDY FQASTPVSEI GSLNIGNRPT 750
SRKPTTSIAD LRAIPWVLAW SQSRVMLPGW YGTGSAFQQW VAAGPESESQ 800
RVEMLHDLYQ RWPFFRSVLS NMAQVLAKSD LGLAARYAEL VVDEALRRRV 850
FDKIADEHRR TIAIHKLITG HDDLLADNPA LARSVFNRFP YLEPLNHLQV 900
ELLRRYRSGH DDEMVQRGIL LTMNGLASAL RNSG 934
Length:934
Mass (Da):102,516
Last modified:April 27, 2001 - v2
Checksum:i3EE8FD762EC45180
GO

Sequence cautioni

The sequence AAA17132.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00013 Genomic DNA. Translation: AAA17132.1. Different initiation.
AL583919 Genomic DNA. Translation: CAC30086.1.
PIRiB86981.
S72765.
RefSeqiNP_301490.1. NC_002677.1.
WP_010907814.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30086; CAC30086; CAC30086.
GeneIDi909360.
KEGGimle:ML0578.
PATRICi18052120. VBIMycLep78757_1007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00013 Genomic DNA. Translation: AAA17132.1 . Different initiation.
AL583919 Genomic DNA. Translation: CAC30086.1 .
PIRi B86981.
S72765.
RefSeqi NP_301490.1. NC_002677.1.
WP_010907814.1. NC_002677.1.

3D structure databases

ProteinModelPortali P46710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0578.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30086 ; CAC30086 ; CAC30086 .
GeneIDi 909360.
KEGGi mle:ML0578.
PATRICi 18052120. VBIMycLep78757_1007.

Organism-specific databases

Lepromai ML0578.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ELSTISC.
OrthoDBi EOG6TJ7T8.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCAPP_MYCLE
AccessioniPrimary (citable) accession number: P46710
Secondary accession number(s): Q9CCN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi