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P46710 (CAPP_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppc
Ordered Locus Names:ML0578
ORF Names:B1496_C3_207
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the PEPCase type 1 family.

Sequence caution

The sequence AAA17132.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
PRO_0000166600

Sites

Active site1611 By similarity
Active site5931 By similarity

Sequences

Sequence LengthMass (Da)Tools
P46710 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 3EE8FD762EC45180

FASTA934102,516
        10         20         30         40         50         60 
MVEFSDAILE PIGAVQRTRV GREATEPMRA DIRLLGTILG DTLREQNGDE VFDLVERVRV 

        70         80         90        100        110        120 
ESFRVRRSEI DRADMARMFS GLDIHLAIPI IRAFSHFALL ANVAEDIHRE RRRHIHLDAG 

       130        140        150        160        170        180 
EPLRDSSLAA TYAKLDLAKL DSATVADALT GAVVSPVITA HPTETRRRTV FVTQRRITEL 

       190        200        210        220        230        240 
MRLHAEGHTE TADGRSIERE LRRQILTLWQ TALIRLARLQ ISDEIDVGLR YYSAALFHVI 

       250        260        270        280        290        300 
PQVNSEVRNA LRARWPDAEL LSGPILQPGS WIGGDRDGNP NVTADVVRRA TGSAAYTVVA 

       310        320        330        340        350        360 
HYLAELTHLE QELSMSARLI TVTPELATLA ASCQDAACAD EPYRRALRVI RGRLSSTAAH 

       370        380        390        400        410        420 
ILDQQPPNQL GLGLPPYSTP AELCADLDTI EASLCTHGAA LLADDRLALL REGVGVFGFH 

       430        440        450        460        470        480 
LCGLDMRQNS DVHEEVVAEL LAWAGMHQDY SSLPEDQRVK LLVAELGNRR PLVGDRAQLS 

       490        500        510        520        530        540 
DLARGELAVL AAAAHAVELY GSAAVPNYII SMCQSVSDVL EVAILLKETG LLDASGSQPY 

       550        560        570        580        590        600 
CPVGISPLFE TIDDLHNGAA ILHAMLELPL YRTLVAARGN WQEVMLGYSD SNKDGGYLAA 

       610        620        630        640        650        660 
NWAVYRAELA LVDVARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA VNGSLRLTEQ 

       670        680        690        700        710        720 
GEVIAAKYAE PQIARRNLES LVAATLESTL LDVEGLGDAA ESAYAILDEV AGLARRSYAE 

       730        740        750        760        770        780 
LVNTPGFVDY FQASTPVSEI GSLNIGNRPT SRKPTTSIAD LRAIPWVLAW SQSRVMLPGW 

       790        800        810        820        830        840 
YGTGSAFQQW VAAGPESESQ RVEMLHDLYQ RWPFFRSVLS NMAQVLAKSD LGLAARYAEL 

       850        860        870        880        890        900 
VVDEALRRRV FDKIADEHRR TIAIHKLITG HDDLLADNPA LARSVFNRFP YLEPLNHLQV 

       910        920        930 
ELLRRYRSGH DDEMVQRGIL LTMNGLASAL RNSG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00013 Genomic DNA. Translation: AAA17132.1. Different initiation.
AL583919 Genomic DNA. Translation: CAC30086.1.
PIRB86981.
S72765.
RefSeqNP_301490.1. NC_002677.1.

3D structure databases

ProteinModelPortalP46710.
ModBaseSearch...

Protein-protein interaction databases

STRING272631.ML0578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30086; CAC30086; CAC30086.
GeneID909360.
KEGGmle:ML0578.
PATRIC18052120. VBIMycLep78757_1007.

Organism-specific databases

LepromaML0578.
CMRSearch...

Phylogenomic databases

eggNOGCOG2352.
HOGENOMHOG000238647.
KOK01595.
OMAAIPWVFG.
ProtClustDBPRK00009.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPP_MYCLE
AccessionPrimary (citable) accession number: P46710
Secondary accession number(s): Q9CCN5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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