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P46710

- CAPP_MYCLE

UniProt

P46710 - CAPP_MYCLE

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.By similarity

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei161 – 1611By similarity
    Active sitei593 – 5931By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
    Short name:
    PEPC
    Short name:
    PEPCase
    Gene namesi
    Name:ppc
    Ordered Locus Names:ML0578
    ORF Names:B1496_C3_207
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0578.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Phosphoenolpyruvate carboxylasePRO_0000166600Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0578.

    Structurei

    3D structure databases

    ProteinModelPortaliP46710.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG2352.
    HOGENOMiHOG000238647.
    KOiK01595.
    OMAiELSTISC.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46710-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEFSDAILE PIGAVQRTRV GREATEPMRA DIRLLGTILG DTLREQNGDE    50
    VFDLVERVRV ESFRVRRSEI DRADMARMFS GLDIHLAIPI IRAFSHFALL 100
    ANVAEDIHRE RRRHIHLDAG EPLRDSSLAA TYAKLDLAKL DSATVADALT 150
    GAVVSPVITA HPTETRRRTV FVTQRRITEL MRLHAEGHTE TADGRSIERE 200
    LRRQILTLWQ TALIRLARLQ ISDEIDVGLR YYSAALFHVI PQVNSEVRNA 250
    LRARWPDAEL LSGPILQPGS WIGGDRDGNP NVTADVVRRA TGSAAYTVVA 300
    HYLAELTHLE QELSMSARLI TVTPELATLA ASCQDAACAD EPYRRALRVI 350
    RGRLSSTAAH ILDQQPPNQL GLGLPPYSTP AELCADLDTI EASLCTHGAA 400
    LLADDRLALL REGVGVFGFH LCGLDMRQNS DVHEEVVAEL LAWAGMHQDY 450
    SSLPEDQRVK LLVAELGNRR PLVGDRAQLS DLARGELAVL AAAAHAVELY 500
    GSAAVPNYII SMCQSVSDVL EVAILLKETG LLDASGSQPY CPVGISPLFE 550
    TIDDLHNGAA ILHAMLELPL YRTLVAARGN WQEVMLGYSD SNKDGGYLAA 600
    NWAVYRAELA LVDVARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA 650
    VNGSLRLTEQ GEVIAAKYAE PQIARRNLES LVAATLESTL LDVEGLGDAA 700
    ESAYAILDEV AGLARRSYAE LVNTPGFVDY FQASTPVSEI GSLNIGNRPT 750
    SRKPTTSIAD LRAIPWVLAW SQSRVMLPGW YGTGSAFQQW VAAGPESESQ 800
    RVEMLHDLYQ RWPFFRSVLS NMAQVLAKSD LGLAARYAEL VVDEALRRRV 850
    FDKIADEHRR TIAIHKLITG HDDLLADNPA LARSVFNRFP YLEPLNHLQV 900
    ELLRRYRSGH DDEMVQRGIL LTMNGLASAL RNSG 934
    Length:934
    Mass (Da):102,516
    Last modified:April 27, 2001 - v2
    Checksum:i3EE8FD762EC45180
    GO

    Sequence cautioni

    The sequence AAA17132.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00013 Genomic DNA. Translation: AAA17132.1. Different initiation.
    AL583919 Genomic DNA. Translation: CAC30086.1.
    PIRiB86981.
    S72765.
    RefSeqiNP_301490.1. NC_002677.1.
    WP_010907814.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30086; CAC30086; CAC30086.
    GeneIDi909360.
    KEGGimle:ML0578.
    PATRICi18052120. VBIMycLep78757_1007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00013 Genomic DNA. Translation: AAA17132.1 . Different initiation.
    AL583919 Genomic DNA. Translation: CAC30086.1 .
    PIRi B86981.
    S72765.
    RefSeqi NP_301490.1. NC_002677.1.
    WP_010907814.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P46710.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30086 ; CAC30086 ; CAC30086 .
    GeneIDi 909360.
    KEGGi mle:ML0578.
    PATRICi 18052120. VBIMycLep78757_1007.

    Organism-specific databases

    Lepromai ML0578.

    Phylogenomic databases

    eggNOGi COG2352.
    HOGENOMi HOG000238647.
    KOi K01595.
    OMAi ELSTISC.
    OrthoDBi EOG6TJ7T8.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiCAPP_MYCLE
    AccessioniPrimary (citable) accession number: P46710
    Secondary accession number(s): Q9CCN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3