Reviewed, UniProtKB/Swiss-Prot P46707 (THIL_MYCLE)

Names and origin

Protein names

Recommended name:
    Probable acetyl-CoA acetyltransferase
    EC=2.3.1.9
Alternative name(s):
    Acetoacetyl-CoA thiolase

Gene names

Name:	fadA4
Ordered Locus Names:	ML1158
ORF Names:	B1549_C1_166

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 acetyl-CoA = CoA + acetoacetyl-CoA.
Sequence similarities	Belongs to the thiolase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	acetyl-CoA C-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Probable acetyl-CoA acetyltransferase		PRO_0000206457
Sites
	Active site	88	1	Acyl-thioester intermediate By similarity
	Active site	349	1	Proton acceptor By similarity
	Active site	379	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46707-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 9055A3BC878D47E1	FASTA	393	40,529
	10 20 30 40 50 60 MTTSVIVTGA RTPIGKLMGS LKDFSASDLG AITIAAALKK ANVAPSIVQY VIIGQVLTAG 70 80 90 100 110 120 AGQMPARQAA VAAGIGWDVP ALTINKMCLS GLDAIALADQ LIRAGEFDVV VAGGQESMTK 130 140 150 160 170 180 APHLLMDSRS GYKYGDVTIV DHLAYDGLHD VFTNQPMGAL TEQRNDVEKF TRQEQDEFAA 190 200 210 220 230 240 RSHQKAAAAW KDGVFADEVV PVSIPQSKGD SLQFTEDEGI RANTSAESLA GLKPAFRCGG 250 260 270 280 290 300 TITPGSASQI SDGAATVVVM NKEKAQQLGL TWLVEIGAHG VVAGPDSTLQ SQPANAIKKA 310 320 330 340 350 360 VDREGISVEQ LDVVEINEAF AAVALASARE LGIAPELVNV NGGAIAVGHP LGMSGARITL 370 380 390 HVALELARRG SGYGVAALCG AGGQGDALIL RAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00014 Genomic DNA. Translation: AAA50881.1. AL583921 Genomic DNA. Translation: CAC31539.1.
PIR	S72804.
RefSeq	NP_301848.1.
3D structure databases
HSSP	HSSP built from PDB template 1PXT based on UniProtKB P27796.
ModBase	Search...
Genome annotation databases
GeneID	910257.
GenomeReviews	Gene locus ML1158 in contig AL450380_GR.
KEGG	mle:ML1158.
NMPDR	fig|272631.1.peg.720.
Organism-specific databases
Leproma	ML1158.
CMR	Search...
Phylogenomic databases
HOGENOM	P46707.
OMA	DANTHDG.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1158-MON.
BRENDA	2.3.1.9. 808.
Family and domain databases
InterPro	IPR002155. Thiolase. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 1 hit.
PANTHER	PTHR18919. Thiolase. 1 hit.
Pfam	PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. [Graphical view]
PIRSF	PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
TIGRFAMs	TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITE	PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIL_MYCLE

Accession

Primary (citable) accession number: P46707

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)