P46705 (MURI_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	ML1172
ORF Names:	B1549_C2_210

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Glutamate racemase HAMAP MF_00258		PRO_0000095488

Sequences

	Sequence		Length	Mass (Da)
	P46705 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 41FC66FCEA48AD06	FASTA	272	28,855
	10 20 30 40 50 60 MSSPLLPVGV FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLSIP EIRAHALAIC 70 80 90 100 110 120 DDLVGRGVKI LVIACNTASA ACLRDARERY DVPVVEVILP AVRRAVAATR NGRIGVIGTR 130 140 150 160 170 180 ATIASHAYQD AFAAARDTEI TAVACPRFVD FVECGVTSGR QVLGLAEGYL EPLQRSGVDT 190 200 210 220 230 240 LVLGCTHYPL LAGLIQLAMG ENVTLVSSAE ETAKEVLRVL TERDLLRRHD APPVNRVFEA 250 260 270 TGDPEAFIQL AARFLGPAVS GVQPARLHSR VR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00014 Genomic DNA. Translation: AAA50890.1. AL583921 Genomic DNA. Translation: CAC31553.1.
PIR	S72790.
RefSeq	NP_301854.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P46705.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029013; EBMYCP00000028619; EBMYCG00000029008.
GeneID	910270.
GenomeReviews	Gene locus ML1172 in contig AL450380_GR.
KEGG	mle:ML1172.
NMPDR	fig|272631.1.peg.726.
PATRIC	18054376. VBIMycLep78757_2129.
Organism-specific databases
Leproma	ML1172.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016063.
HOGENOM	HBG645102.
OMA	PQEDTIY.
ProtClustDB	PRK00865.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1172-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_MYCLE

Accession

Primary (citable) accession number: P46705

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program