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Protein

Glutamate racemase

Gene

murI

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Proton donor/acceptorUniRule annotation1
Active sitei185Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1275-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:ML1172
ORF Names:B1549_C2_210
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi

Organism-specific databases

LepromaiML1172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000954881 – 272Glutamate racemaseAdd BLAST272

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1172

Structurei

3D structure databases

ProteinModelPortaliP46705
SMRiP46705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Substrate bindingUniRule annotation2
Regioni44 – 45Substrate bindingUniRule annotation2
Regioni76 – 77Substrate bindingUniRule annotation2
Regioni186 – 187Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
HOGENOMiHOG000262396
KOiK01776
OMAiVYGCTHY
OrthoDBiPOG091H00P1

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPLLPVGV FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLSIP
60 70 80 90 100
EIRAHALAIC DDLVGRGVKI LVIACNTASA ACLRDARERY DVPVVEVILP
110 120 130 140 150
AVRRAVAATR NGRIGVIGTR ATIASHAYQD AFAAARDTEI TAVACPRFVD
160 170 180 190 200
FVECGVTSGR QVLGLAEGYL EPLQRSGVDT LVLGCTHYPL LAGLIQLAMG
210 220 230 240 250
ENVTLVSSAE ETAKEVLRVL TERDLLRRHD APPVNRVFEA TGDPEAFIQL
260 270
AARFLGPAVS GVQPARLHSR VR
Length:272
Mass (Da):28,855
Last modified:November 1, 1995 - v1
Checksum:i41FC66FCEA48AD06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00014 Genomic DNA Translation: AAA50890.1
AL583921 Genomic DNA Translation: CAC31553.1
PIRiS72790
RefSeqiNP_301854.1, NC_002677.1
WP_010908178.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31553; CAC31553; CAC31553
GeneIDi910270
KEGGimle:ML1172
PATRICifig|272631.5.peg.2129

Similar proteinsi

Entry informationi

Entry nameiMURI_MYCLE
AccessioniPrimary (citable) accession number: P46705
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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