Reviewed, UniProtKB/Swiss-Prot P46703 (ACDP_MYCLE)

Names and origin

Protein names

Recommended name:
    Probable acyl-CoA dehydrogenase fadE25
    EC=1.3.99.-

Gene names

Name:	fadE25
Synonyms:	acd
Ordered Locus Names:	ML0737
ORF Names:	B1308_F1_34

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Probable acyl-CoA dehydrogenase fadE25		PRO_0000201187

Sequences

	Sequence		Length	Mass (Da)
	P46703-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EFC80CDB3ED884B1	FASTA	389	41,719
	10 20 30 40 50 60 MVGWSGNPLF DLFKLPEEHN ELRATIRALA EKEIAPHAAD VDQRARFPEE ALAALNASGF 70 80 90 100 110 120 NAIHVPEEYG GQGADSVAAC IVIEEVARVD ASASLIPAVN KLGTMGLILR GSEELKKQVL 130 140 150 160 170 180 PSLAAEGAMA SYALSEREAG SDAASMRTRA KADGDDWILN GFKCWITNGG KSTWYTVMAV 190 200 210 220 230 240 TDPDKGANGI SAFIVHKDDE GFSIGPKEKK LGIKGSPTTE LYFDKCRIPG DRIIGEPGTG 250 260 270 280 290 300 FKTALATLDH TRPTIGAQAV GIAQGALDAA IVYTKDRKQF GESISTFQSI QFMLADMAMK 310 320 330 340 350 360 VEAARLIVYA AAARAERGEP DLGFISAASK CFASDIAMEV TTDAVQLFGG AGYTSDFPVE 370 380 RFMRDAKITQ IYEGTNQIQR VVMSRALLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the mycobacterial sigma gene cluster." Doukhan L., Predich M., Nair G., Dussurget O., Mandic-Mulec I., Cole S.T., Smith D.R., Smith I. Gene 165:67-70(1995) [PubMed: 7489918] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00012 Genomic DNA. Translation: AAA85936.1. AL583919 Genomic DNA. Translation: CAC30246.1.
PIR	B87001.
RefSeq	NP_301577.1.
3D structure databases
HSSP	HSSP built from PDB template 1JQI based on UniProtKB P15651.
ModBase	Search...
Genome annotation databases
GeneID	909685.
GenomeReviews	Gene locus ML0737 in contig AL450380_GR.
KEGG	mle:ML0737.
NMPDR	fig|272631.1.peg.449.
Organism-specific databases
Leproma	ML0737.
CMR	Search...
Phylogenomic databases
HOGENOM	P46703.
OMA	P46703. HYDARIN.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0737-MON.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACDP_MYCLE

Accession

Primary (citable) accession number: P46703

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)