Reviewed, UniProtKB/Swiss-Prot P46702 (PUR6_MYCLE)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	ML0736
ORF Names:	B1308_F3_98

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074976
Sites
	Binding site	13	1	Substrate By similarity
	Binding site	16	1	Substrate By similarity
	Binding site	43	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46702-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: DBB69909059894E3	FASTA	171	17,912
	10 20 30 40 50 60 MTRQPRVGVI MGSDSDWSVM QDAAHALAEF DIPIEVRVVS AHRTPAEMFD YARNAVDRSI 70 80 90 100 110 120 AVIIAGAGGA AHLPGMVASA TPLPVIGVPV PLARLDGLDS LLSIVQMPAG VPVATVSIGG 130 140 150 160 170 ARNAGLLAVR ILGSSDLQLR AQLVAFQDRL ADTVRAKDAD LQRFRGKLIG D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the mycobacterial sigma gene cluster." Doukhan L., Predich M., Nair G., Dussurget O., Mandic-Mulec I., Cole S.T., Smith D.R., Smith I. Gene 165:67-70(1995) [PubMed: 7489918] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00012 Genomic DNA. Translation: AAA85943.1. AL583919 Genomic DNA. Translation: CAC30245.1.
PIR	A87001.
RefSeq	NP_301576.1.
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Genome annotation databases
GeneID	909681.
GenomeReviews	Gene locus ML0736 in contig AL450380_GR.
KEGG	mle:ML0736.
NMPDR	fig|272631.1.peg.448.
Organism-specific databases
Leproma	ML0736.
CMR	Search...
Phylogenomic databases
HOGENOM	P46702.
OMA	GVVMGSS.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0736-MON.
BRENDA	4.1.1.21. 808.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_MYCLE

Accession

Primary (citable) accession number: P46702

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)