Reviewed,
UniProtKB/Swiss-Prot P46695 (IEX1_HUMAN)
Last modified
October 13, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Radiation-inducible immediate-early gene IEX-1 Alternative name(s): Immediate early protein GLY96 Immediate early response 3 protein PACAP-responsive gene 1 protein Short name=Protein PRG1 Differentiation-dependent gene 2 protein Short name=Protein DIF-2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 156 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Induction | By radiation, TPA, okadaic acid and TNF-alpha. |
| Post-translational modification | Glycosylated. |
| Sequence similarities | Belongs to the IER3 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal-anchor Transmembrane |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | anatomical structure morphogenesis Ref.3 Traceable author statement. Source: ProtInc anti-apoptosisTraceable author statement. Source: ProtInc apoptosis Ref.3Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 156 | 156 | Radiation-inducible immediate-early gene IEX-1 | PRO_0000084159 | |||||
Regions | |||||||||
| Topological domain | 1 – 82 | 82 | Cytoplasmic Potential | ||||||
| Transmembrane | 83 – 99 | 17 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 100 – 156 | 57 | Extracellular Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 133 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 127 | 1 | P → A: dbSNP rs3094124. Ref.6 | VAR_058496 | |||||
Experimental info | |||||||||
| Sequence conflict | 54 | 1 | A → G in AAB36278. Ref.1 | ||||||
| Sequence conflict | 106 | 1 | P → R in AAB36278. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and characterization of a radiation-inducible glycosylated human early-response gene." Kondratyev A.D., Chung K.-N., Jung M.O. Cancer Res. 56:1498-1502(1996) [PubMed: 8603392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line." Schaefer H., Trauzold A., Siegel E.G., Folsch U.R., Schmidt W.E. Cancer Res. 56:2641-2648(1996) [PubMed: 8653710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine." Pietzsch A., Buechler C., Aslanidis C., Schmitz G. Biochem. Biophys. Res. Commun. 235:4-9(1997) [PubMed: 9196025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-127. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Entry information
| Entry name | IEX1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P46695 Secondary accession number(s): Q5SU30, Q92691, Q93044 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


