SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46694

- IEX1_MOUSE

UniProt

P46694 - IEX1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Radiation-inducible immediate-early gene IEX-1

Gene
Ier3, Gly96, Iex1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival By similarity. As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.1 Publication

GO - Biological processi

  1. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  2. mitotic G2 DNA damage checkpoint Source: MGI
  3. negative regulation of apoptotic process Source: InterPro
  4. negative regulation of glycolytic process Source: MGI
  5. negative regulation of inflammatory response Source: MGI
  6. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: MGI
  7. negative regulation of systemic arterial blood pressure Source: MGI
  8. positive regulation of protein catabolic process Source: MGI
  9. regulation of DNA repair Source: MGI
  10. regulation of nucleocytoplasmic transport Source: MGI
  11. regulation of reactive oxygen species metabolic process Source: MGI
  12. regulation of response to DNA damage stimulus Source: MGI
  13. response to protozoan Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Radiation-inducible immediate-early gene IEX-1
Alternative name(s):
Immediate early protein GLY96
Immediate early response 3 protein
Gene namesi
Name:Ier3
Synonyms:Gly96, Iex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:104814. Ier3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8585Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei86 – 10217Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini103 – 15351Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Radiation-inducible immediate-early gene IEX-1PRO_0000084160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine By similarity
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP46694.

PTM databases

PhosphoSiteiP46694.

Expressioni

Tissue specificityi

Expressed predominantly in the lung, testes and the uterus.

Inductioni

By serum growth factors and TPA.

Gene expression databases

ArrayExpressiP46694.
BgeeiP46694.
CleanExiMM_IER3.
GenevestigatoriP46694.

Interactioni

Subunit structurei

Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003635.

Family & Domainsi

Sequence similaritiesi

Belongs to the IER3 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46208.
HOVERGENiHBG000172.
InParanoidiP46694.
PhylomeDBiP46694.

Family and domain databases

InterProiIPR024829. IEX-1.
[Graphical view]
PANTHERiPTHR16915. PTHR16915. 1 hit.
PRINTSiPR02100. GENEIEX1.

Sequencei

Sequence statusi: Complete.

P46694-1 [UniParc]FASTAAdd to Basket

« Hide

MCHSRNHLHT MTGLRAPSPA PSTGPELRRG SGPEIFTFDP LPERAVVSTA    50
RLNTSRGHRK RSRRVLYPRV VRRQLPTEEP NIAKRVLFLL FAIIFCQILM 100
AEEGVSQPLA PEDATSAVTP EPISAPITAP PVLEPLNLTS ESSDYALDLK 150
AFL 153
Length:153
Mass (Da):16,875
Last modified:November 1, 1995 - v1
Checksum:iF4429E3B0120DE11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67644 mRNA. No translation available.
PIRiS33363.
UniGeneiMm.25613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67644 mRNA. No translation available.
PIRi S33363.
UniGenei Mm.25613.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000003635.

PTM databases

PhosphoSitei P46694.

Proteomic databases

PRIDEi P46694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:104814. Ier3.

Phylogenomic databases

eggNOGi NOG46208.
HOVERGENi HBG000172.
InParanoidi P46694.
PhylomeDBi P46694.

Miscellaneous databases

ChiTaRSi IER3. mouse.
PROi P46694.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46694.
Bgeei P46694.
CleanExi MM_IER3.
Genevestigatori P46694.

Family and domain databases

InterProi IPR024829. IEX-1.
[Graphical view ]
PANTHERi PTHR16915. PTHR16915. 1 hit.
PRINTSi PR02100. GENEIEX1.
ProtoNeti Search...

Publicationsi

  1. "Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein."
    Charles C.H., Yoon J.K., Simske J.S., Lau L.F.
    Oncogene 8:797-801(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis."
    Hamidi T., Algul H., Cano C.E., Sandi M.J., Molejon M.I., Riemann M., Calvo E.L., Lomberk G., Dagorn J.C., Weih F., Urrutia R., Schmid R.M., Iovanna J.L.
    J. Clin. Invest. 122:2092-2103(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIEX1_MOUSE
AccessioniPrimary (citable) accession number: P46694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi