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P46694

- IEX1_MOUSE

UniProt

P46694 - IEX1_MOUSE

Protein

Radiation-inducible immediate-early gene IEX-1

Gene

Ier3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival By similarity. As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.By similarity1 Publication

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    2. mitotic G2 DNA damage checkpoint Source: MGI
    3. negative regulation of apoptotic process Source: InterPro
    4. negative regulation of glycolytic process Source: MGI
    5. negative regulation of inflammatory response Source: MGI
    6. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: MGI
    7. negative regulation of systemic arterial blood pressure Source: MGI
    8. positive regulation of protein catabolic process Source: MGI
    9. regulation of DNA repair Source: MGI
    10. regulation of nucleocytoplasmic transport Source: MGI
    11. regulation of reactive oxygen species metabolic process Source: MGI
    12. regulation of response to DNA damage stimulus Source: MGI
    13. response to protozoan Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Radiation-inducible immediate-early gene IEX-1
    Alternative name(s):
    Immediate early protein GLY96
    Immediate early response 3 protein
    Gene namesi
    Name:Ier3
    Synonyms:Gly96, Iex1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:104814. Ier3.

    Subcellular locationi

    Membrane By similarity; Single-pass type II membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Radiation-inducible immediate-early gene IEX-1PRO_0000084160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311PhosphoserineBy similarity
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP46694.

    PTM databases

    PhosphoSiteiP46694.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the lung, testes and the uterus.

    Inductioni

    By serum growth factors and TPA.

    Gene expression databases

    ArrayExpressiP46694.
    BgeeiP46694.
    CleanExiMM_IER3.
    GenevestigatoriP46694.

    Interactioni

    Subunit structurei

    Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000003635.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8585CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 15351ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10217Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IER3 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46208.
    HOVERGENiHBG000172.
    InParanoidiP46694.
    PhylomeDBiP46694.

    Family and domain databases

    InterProiIPR024829. IEX-1.
    [Graphical view]
    PANTHERiPTHR16915. PTHR16915. 1 hit.
    PRINTSiPR02100. GENEIEX1.

    Sequencei

    Sequence statusi: Complete.

    P46694-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCHSRNHLHT MTGLRAPSPA PSTGPELRRG SGPEIFTFDP LPERAVVSTA    50
    RLNTSRGHRK RSRRVLYPRV VRRQLPTEEP NIAKRVLFLL FAIIFCQILM 100
    AEEGVSQPLA PEDATSAVTP EPISAPITAP PVLEPLNLTS ESSDYALDLK 150
    AFL 153
    Length:153
    Mass (Da):16,875
    Last modified:November 1, 1995 - v1
    Checksum:iF4429E3B0120DE11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67644 mRNA. No translation available.
    PIRiS33363.
    UniGeneiMm.25613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67644 mRNA. No translation available.
    PIRi S33363.
    UniGenei Mm.25613.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000003635.

    PTM databases

    PhosphoSitei P46694.

    Proteomic databases

    PRIDEi P46694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:104814. Ier3.

    Phylogenomic databases

    eggNOGi NOG46208.
    HOVERGENi HBG000172.
    InParanoidi P46694.
    PhylomeDBi P46694.

    Miscellaneous databases

    ChiTaRSi IER3. mouse.
    PROi P46694.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46694.
    Bgeei P46694.
    CleanExi MM_IER3.
    Genevestigatori P46694.

    Family and domain databases

    InterProi IPR024829. IEX-1.
    [Graphical view ]
    PANTHERi PTHR16915. PTHR16915. 1 hit.
    PRINTSi PR02100. GENEIEX1.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein."
      Charles C.H., Yoon J.K., Simske J.S., Lau L.F.
      Oncogene 8:797-801(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis."
      Hamidi T., Algul H., Cano C.E., Sandi M.J., Molejon M.I., Riemann M., Calvo E.L., Lomberk G., Dagorn J.C., Weih F., Urrutia R., Schmid R.M., Iovanna J.L.
      J. Clin. Invest. 122:2092-2103(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiIEX1_MOUSE
    AccessioniPrimary (citable) accession number: P46694
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3