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Protein

Gap junction beta-2 protein

Gene

GJB2

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-2 protein
Alternative name(s):
Connexin-26
Short name:
Cx26
Gene namesi
Name:GJB2
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 131CytoplasmicSequence analysisAdd BLAST33
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Topological domaini155 – 192ExtracellularSequence analysisAdd BLAST38
Transmembranei193 – 215HelicalSequence analysisAdd BLAST23
Topological domaini216 – 226CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578611 – 226Gap junction beta-2 proteinAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 180By similarity
Disulfide bondi60 ↔ 174By similarity
Disulfide bondi64 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000140773.
HOVERGENiHBG009576.
KOiK07621.
OMAiVMYDGFA.
OrthoDBiEOG091G0FKH.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWSALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYYRH
110 120 130 140 150
EKKRKFIRGE IKTEFKDIEE IKNQKVRIEG SLWWTYTGSI FFRVIFEAAF
160 170 180 190 200
MYVFYVMYDG FAMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG
210 220
ICILLNVTEL CYLLIRFCSG KSKKPV
Length:226
Mass (Da):26,215
Last modified:November 1, 1995 - v1
Checksum:iDCE2F0C1B4FCEF7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17592 mRNA. Translation: AAA67446.1.
RefSeqiNP_001009780.1. NM_001009780.1.
UniGeneiOar.400.

Genome annotation databases

EnsembliENSOART00000018600; ENSOARP00000018338; ENSOARG00000017089.
GeneIDi443345.
KEGGioas:443345.

Similar proteinsi

Entry informationi

Entry nameiCXB2_SHEEP
AccessioniPrimary (citable) accession number: P46691
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families