Zinc finger protein ZIC 1 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P46684 (ZIC1_MOUSE)

Last modified June 16, 2009. Version 75. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein of the cerebellum 1

Gene names

Name:	Zic1
Synonyms:	Zic

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during maturation of the cerebellum. Ref.1
Subcellular location	Nucleus.
Tissue specificity	CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Ref.1
Developmental stage	In the early embryonic stage, it is expressed in the dorsal half of the neural tube and adjacent mesenchyme, and in the developing cerebellum it is expressed persistently in the granule cell lineage throughout the prenatal and postnatal periods. Ref.1
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Hide | Top

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	behavior Inferred from mutant phenotype. Source: MGI brain development Ref.1 Inferred from direct assay. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW inner ear morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB pattern specification process Inferred from direct assay. Source: UniProtKB regulation of smoothened signaling pathway Inferred from physical interaction. Source: UniProtKB skeletal system development Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GLI1	P08151	2	EBI-308006,EBI-308084	From a different organism.
Gli2	Q8K0K3	2	EBI-308006,EBI-308039
GLI3	P10071	2	EBI-308006,EBI-308055	From a different organism.

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 447

447

Zinc finger protein ZIC 1

PRO_0000047245

Regions

Zinc finger

225 – 260

C2H2-type 1; atypical

Zinc finger

269 – 296

C2H2-type 2; atypical

Zinc finger

302 – 326

C2H2-type 3

Zinc finger

332 – 356

C2H2-type 4

Zinc finger

362 – 384

C2H2-type 5

Compositional bias

73 – 76

Poly-Ala

Compositional bias

79 – 82

Poly-His

Compositional bias

110 – 116

Poly-Ala

Compositional bias

386 – 440

Ser-rich

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

P46684-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9185912BDBCCE23E
Show »

FASTA

447

48,416

        10         20         30         40         50         60 
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG 

        70         80         90        100        110        120 
QTAFTSQAPG YRAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL 

       130        140        150        160        170        180 
FAASAGGFGG PHGHTDAAGH LLFSGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ 

       190        200        210        220        230        240 
VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK 

       250        260        270        280        290        300 
SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 

       310        320        330        340        350        360 
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK 

       370        380        390        400        410        420 
PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPTTDNPTTS 

       430        440 
SMSPSSSAVH HTAGHSALSS NFNEWYV

« Hide

Hide | Top

References

[1]	"A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells." Aruga J., Yokota N., Hashimoto M., Furuichi T., Fukuda M., Mikoshiba K. J. Neurochem. 63:1880-1890(1994) [PubMed: 7931345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: ICR. Tissue: Cerebellum.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	D32167 mRNA. Translation: BAA06878.1.
IPI	IPI00136023.
PIR	I56511.
UniGene	Mm.335350 Mm.473691
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46684. 3 interactions.
Genome annotation databases
Ensembl	ENSMUSG00000032368. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:106683. Zic1.
Phylogenomic databases
HOGENOM	P46684.
HOVERGEN	P46684.
Gene expression databases
ArrayExpress	P46684.
Bgee	P46684.
CleanEx	MM_ZIC1.
GermOnline	ENSMUSG00000032368. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Hide | Top

Entry information

Entry name

ZIC1_MOUSE

Accession

Primary (citable) accession number: P46684

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents