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Protein

Ankyrin repeat-containing protein YAR1

Gene

YAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal rate of cell proliferation.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • regulation of protein localization Source: SGD
  • response to osmotic stress Source: SGD
  • ribosomal small subunit biogenesis Source: SGD
  • ribosomal small subunit export from nucleus Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-34125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat-containing protein YAR1
Gene namesi
Name:YAR1
Ordered Locus Names:YPL239W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL239W.
SGDiS000006160. YAR1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Ankyrin repeat-containing protein YAR1PRO_0000067079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP46683.
PeptideAtlasiP46683.

PTM databases

iPTMnetiP46683.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RPS3P057502EBI-20829,EBI-16140

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi35924. 58 interactions.
IntActiP46683. 4 interactions.
MINTiMINT-2493177.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2213Combined sources
Helixi25 – 3410Combined sources
Helixi38 – 436Combined sources
Turni47 – 493Combined sources
Helixi53 – 597Combined sources
Helixi63 – 7614Combined sources
Helixi79 – 868Combined sources
Helixi96 – 1027Combined sources
Helixi106 – 1149Combined sources
Helixi130 – 1367Combined sources
Helixi140 – 14910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BSZX-ray2.84B1-200[»]
ProteinModelPortaliP46683.
SMRiP46683. Positions 7-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati49 – 7830ANK 1Add
BLAST
Repeati92 – 12130ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000111159.
InParanoidiP46683.
KOiK06867.
OMAiENVGWEE.
OrthoDBiEOG7B8SGP.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHSEPLDQ EDQDTIILDA RAGDLDSLKD IFTTLVSPEL LSTCKESESD
60 70 80 90 100
STALHMAAAN GHIETVRYIL ETVSRANSAE DLKAFVNEVN KTGNTALHWA
110 120 130 140 150
SLNGKLDVVK LLCDEYEADP FIRNKFGHDA IFEAENSGKE EVETYFLKKY
160 170 180 190 200
DVEPEDDEED TQTEGKNSVQ ITKGTEIEQV TKEATEALRE ETEKLNINKD
Length:200
Mass (Da):22,356
Last modified:November 1, 1995 - v1
Checksum:i8089CFC062E65395
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181A → P no nucleotide entry (PubMed:3136928).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34385 Genomic DNA. Translation: AAB60315.1.
Z67751 Genomic DNA. Translation: CAA91605.1.
Z73595 Genomic DNA. Translation: CAA97960.1.
AY558138 Genomic DNA. Translation: AAS56464.1.
M21813 Genomic DNA. No translation available.
BK006949 Genomic DNA. Translation: DAA11198.1.
PIRiS61025.
RefSeqiNP_015085.1. NM_001184053.1.

Genome annotation databases

EnsemblFungiiYPL239W; YPL239W; YPL239W.
GeneIDi855837.
KEGGisce:YPL239W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34385 Genomic DNA. Translation: AAB60315.1.
Z67751 Genomic DNA. Translation: CAA91605.1.
Z73595 Genomic DNA. Translation: CAA97960.1.
AY558138 Genomic DNA. Translation: AAS56464.1.
M21813 Genomic DNA. No translation available.
BK006949 Genomic DNA. Translation: DAA11198.1.
PIRiS61025.
RefSeqiNP_015085.1. NM_001184053.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BSZX-ray2.84B1-200[»]
ProteinModelPortaliP46683.
SMRiP46683. Positions 7-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35924. 58 interactions.
IntActiP46683. 4 interactions.
MINTiMINT-2493177.

PTM databases

iPTMnetiP46683.

Proteomic databases

MaxQBiP46683.
PeptideAtlasiP46683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL239W; YPL239W; YPL239W.
GeneIDi855837.
KEGGisce:YPL239W.

Organism-specific databases

EuPathDBiFungiDB:YPL239W.
SGDiS000006160. YAR1.

Phylogenomic databases

HOGENOMiHOG000111159.
InParanoidiP46683.
KOiK06867.
OMAiENVGWEE.
OrthoDBiEOG7B8SGP.

Enzyme and pathway databases

BioCyciYEAST:G3O-34125-MONOMER.

Miscellaneous databases

PROiP46683.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation."
    Lycan D.E., Stafford K.A., Bollinger W., Breeden L.L.
    Gene 171:33-40(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96902 / S288c / TD28.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process."
    Donahue T.F., Cigan A.M., Pabich E.K., Valavicius B.C.
    Cell 54:621-632(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-200.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYAR1_YEAST
AccessioniPrimary (citable) accession number: P46683
Secondary accession number(s): D6W3D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 13100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.