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Protein

Actin-interacting protein 1

Gene

AIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: SGD
  • barbed-end actin filament capping Source: SGD
  • negative regulation of cytokinesis Source: SGD
  • response to osmotic stress Source: SGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32792-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-interacting protein 1
Gene namesi
Name:AIP1
Ordered Locus Names:YMR092C
ORF Names:YM9582.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR092C.
SGDiS000004698. AIP1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • actin filament Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000508412 – 615Actin-interacting protein 1Add BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP46680.
PRIDEiP46680.

PTM databases

iPTMnetiP46680.

Interactioni

Subunit structurei

Interacts with actin and cofilin in a ternary complex.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi35267. 35 interactors.
DIPiDIP-890N.
IntActiP46680. 7 interactors.
MINTiMINT-399089.

Structurei

Secondary structure

1615
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Beta strandi25 – 27Combined sources3
Turni28 – 31Combined sources4
Beta strandi32 – 37Combined sources6
Beta strandi40 – 45Combined sources6
Beta strandi55 – 59Combined sources5
Turni61 – 64Combined sources4
Beta strandi67 – 72Combined sources6
Beta strandi80 – 85Combined sources6
Beta strandi88 – 98Combined sources11
Turni99 – 102Combined sources4
Beta strandi103 – 113Combined sources11
Beta strandi119 – 124Combined sources6
Beta strandi128 – 135Combined sources8
Beta strandi141 – 146Combined sources6
Turni147 – 149Combined sources3
Beta strandi152 – 155Combined sources4
Beta strandi163 – 168Combined sources6
Beta strandi170 – 173Combined sources4
Beta strandi175 – 180Combined sources6
Turni181 – 183Combined sources3
Beta strandi184 – 189Combined sources6
Turni190 – 192Combined sources3
Beta strandi193 – 199Combined sources7
Beta strandi201 – 203Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi221 – 226Combined sources6
Beta strandi231 – 235Combined sources5
Turni236 – 238Combined sources3
Beta strandi241 – 244Combined sources4
Beta strandi256 – 271Combined sources16
Beta strandi274 – 280Combined sources7
Turni281 – 284Combined sources4
Beta strandi285 – 291Combined sources7
Helixi297 – 299Combined sources3
Beta strandi301 – 308Combined sources8
Beta strandi311 – 316Combined sources6
Beta strandi321 – 325Combined sources5
Beta strandi328 – 335Combined sources8
Beta strandi342 – 346Combined sources5
Turni347 – 350Combined sources4
Beta strandi351 – 354Combined sources4
Beta strandi359 – 361Combined sources3
Turni362 – 365Combined sources4
Beta strandi366 – 368Combined sources3
Beta strandi375 – 379Combined sources5
Beta strandi387 – 390Combined sources4
Turni391 – 393Combined sources3
Beta strandi394 – 397Combined sources4
Beta strandi400 – 404Combined sources5
Beta strandi409 – 414Combined sources6
Beta strandi416 – 424Combined sources9
Beta strandi427 – 433Combined sources7
Turni434 – 436Combined sources3
Beta strandi439 – 444Combined sources6
Beta strandi449 – 454Combined sources6
Beta strandi456 – 463Combined sources8
Turni464 – 466Combined sources3
Beta strandi469 – 473Combined sources5
Beta strandi476 – 482Combined sources7
Beta strandi491 – 496Combined sources6
Beta strandi500 – 507Combined sources8
Beta strandi512 – 516Combined sources5
Turni517 – 520Combined sources4
Beta strandi521 – 524Combined sources4
Beta strandi534 – 539Combined sources6
Beta strandi555 – 560Combined sources6
Beta strandi565 – 571Combined sources7
Beta strandi577 – 579Combined sources3
Beta strandi587 – 594Combined sources8
Beta strandi597 – 602Combined sources6
Beta strandi607 – 612Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PGUX-ray2.30A/B1-615[»]
1PI6X-ray2.50A1-615[»]
ProteinModelPortaliP46680.
SMRiP46680.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 45WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST44
Repeati46 – 94WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST49
Repeati95 – 146WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST52
Repeati147 – 189WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati190 – 235WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST46
Repeati236 – 280WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST45
Repeati281 – 325WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST45
Repeati326 – 363WD 8PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati364 – 399WD 9PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati400 – 433WD 10PROSITE-ProRule annotation1 PublicationAdd BLAST34
Repeati434 – 473WD 11PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati474 – 516WD 12PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati517 – 569WD 13PROSITE-ProRule annotation1 PublicationAdd BLAST53
Repeati570 – 611WD 14PROSITE-ProRule annotation1 PublicationAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi363 – 366Poly-Ser4

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
InParanoidiP46680.
OMAiACINELT.
OrthoDBiEOG092C1AB2.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSISLKEII PPQPSTQRNF TTHLSYDPTT NAIAYPCGKS AFVRCLDDGD
60 70 80 90 100
SKVPPVVQFT GHGSSVVTTV KFSPIKGSQY LCSGDESGKV IVWGWTFDKE
110 120 130 140 150
SNSVEVNVKS EFQVLAGPIS DISWDFEGRR LCVVGEGRDN FGVFISWDSG
160 170 180 190 200
NSLGEVSGHS QRINACHLKQ SRPMRSMTVG DDGSVVFYQG PPFKFSASDR
210 220 230 240 250
THHKQGSFVR DVEFSPDSGE FVITVGSDRK ISCFDGKSGE FLKYIEDDQE
260 270 280 290 300
PVQGGIFALS WLDSQKFATV GADATIRVWD VTTSKCVQKW TLDKQQLGNQ
310 320 330 340 350
QVGVVATGNG RIISLSLDGT LNFYELGHDE VLKTISGHNK GITALTVNPL
360 370 380 390 400
ISGSYDGRIM EWSSSSMHQD HSNLIVSLDN SKAQEYSSIS WDDTLKVNGI
410 420 430 440 450
TKHEFGSQPK VASANNDGFT AVLTNDDDLL ILQSFTGDII KSVRLNSPGS
460 470 480 490 500
AVSLSQNYVA VGLEEGNTIQ VFKLSDLEVS FDLKTPLRAK PSYISISPSE
510 520 530 540 550
TYIAAGDVMG KILLYDLQSR EVKTSRWAFH TSKINAISWK PAEKGANEEE
560 570 580 590 600
IEEDLVATGS LDTNIFIYSV KRPMKIIKAL NAHKDGVNNL LWETPSTLVS
610
SGADACIKRW NVVLE
Length:615
Mass (Da):67,326
Last modified:November 1, 1995 - v1
Checksum:iB8340BF68DD08257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35666 Genomic DNA. Translation: AAA79141.1.
Z49259 Genomic DNA. Translation: CAA89239.1.
BK006946 Genomic DNA. Translation: DAA09989.1.
PIRiS54468.
RefSeqiNP_013810.1. NM_001182592.1.

Genome annotation databases

EnsemblFungiiYMR092C; YMR092C; YMR092C.
GeneIDi855117.
KEGGisce:YMR092C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35666 Genomic DNA. Translation: AAA79141.1.
Z49259 Genomic DNA. Translation: CAA89239.1.
BK006946 Genomic DNA. Translation: DAA09989.1.
PIRiS54468.
RefSeqiNP_013810.1. NM_001182592.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PGUX-ray2.30A/B1-615[»]
1PI6X-ray2.50A1-615[»]
ProteinModelPortaliP46680.
SMRiP46680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35267. 35 interactors.
DIPiDIP-890N.
IntActiP46680. 7 interactors.
MINTiMINT-399089.

PTM databases

iPTMnetiP46680.

Proteomic databases

MaxQBiP46680.
PRIDEiP46680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR092C; YMR092C; YMR092C.
GeneIDi855117.
KEGGisce:YMR092C.

Organism-specific databases

EuPathDBiFungiDB:YMR092C.
SGDiS000004698. AIP1.

Phylogenomic databases

GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
InParanoidiP46680.
OMAiACINELT.
OrthoDBiEOG092C1AB2.

Enzyme and pathway databases

BioCyciYEAST:G3O-32792-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Miscellaneous databases

EvolutionaryTraceiP46680.
PROiP46680.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIP1_YEAST
AccessioniPrimary (citable) accession number: P46680
Secondary accession number(s): D6VZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.