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Reviewed, UniProtKB/Swiss-Prot P46680 (AIP1_YEAST)

Last modified November 4, 2008. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Actin-interacting protein 1
Gene names
Name: AIP1
Ordered Locus Names: YMR092C
ORF Names: YM9582.17C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length615 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.

Subunit structure

Interacts with actin and cofilin in a ternary complex.

Subcellular location

Cytoplasmcytoskeleton. Cytoplasmcytoskeletonactin patch.

Miscellaneous

Present with 11100 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WD repeat AIP1 family.

Contains 11 WD repeats.

Ontologies

Keywords

   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
WD repeat
   LigandActin-binding
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome

Gene Ontology (GO)

   Biological processactin filament depolymerization Ref.3

Inferred from genetic interaction. Source: SGD

response to osmotic stress

Traceable author statement. Source: SGD

   Cellular componentactin cortical patch

Traceable author statement. Source: SGD

nucleus

Inferred from direct assay. Source: SGD

   Molecular functionactin binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 615615Actin-interacting protein 1
PRO_0000050841

Regions

Repeat62 – 10948WD 1
Repeat114 – 15744WD 2
Repeat158 – 20144WD 3
Repeat204 – 24441WD 4
Repeat251 – 28939WD 5
Repeat337 – 36731WD 6
Repeat370 – 40637WD 7
Repeat442 – 48140WD 8
Repeat486 – 52540WD 9
Repeat529 – 57850WD 10
Repeat583 – 61331WD 11
Compositional bias363 – 3664Poly-Ser

Amino acid modifications

Modified residue3541Phosphoserine
Modified residue3551Phosphotyrosine

Secondary structure

........................................................................................................................... 615
Helix Strand Turn

Details...