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Protein

Actin-interacting protein 1

Gene

AIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: SGD
  • barbed-end actin filament capping Source: SGD
  • negative regulation of cytokinesis Source: SGD
  • response to osmotic stress Source: SGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32792-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-interacting protein 1
Gene namesi
Name:AIP1
Ordered Locus Names:YMR092C
ORF Names:YM9582.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR092C.
SGDiS000004698. AIP1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • actin filament Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 615614Actin-interacting protein 1PRO_0000050841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP46680.

PTM databases

iPTMnetiP46680.

Interactioni

Subunit structurei

Interacts with actin and cofilin in a ternary complex.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi35267. 34 interactions.
DIPiDIP-890N.
IntActiP46680. 7 interactions.
MINTiMINT-399089.

Structurei

Secondary structure

1
615
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Beta strandi25 – 273Combined sources
Turni28 – 314Combined sources
Beta strandi32 – 376Combined sources
Beta strandi40 – 456Combined sources
Beta strandi55 – 595Combined sources
Turni61 – 644Combined sources
Beta strandi67 – 726Combined sources
Beta strandi80 – 856Combined sources
Beta strandi88 – 9811Combined sources
Turni99 – 1024Combined sources
Beta strandi103 – 11311Combined sources
Beta strandi119 – 1246Combined sources
Beta strandi128 – 1358Combined sources
Beta strandi141 – 1466Combined sources
Turni147 – 1493Combined sources
Beta strandi152 – 1554Combined sources
Beta strandi163 – 1686Combined sources
Beta strandi170 – 1734Combined sources
Beta strandi175 – 1806Combined sources
Turni181 – 1833Combined sources
Beta strandi184 – 1896Combined sources
Turni190 – 1923Combined sources
Beta strandi193 – 1997Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi209 – 2146Combined sources
Beta strandi221 – 2266Combined sources
Beta strandi231 – 2355Combined sources
Turni236 – 2383Combined sources
Beta strandi241 – 2444Combined sources
Beta strandi256 – 27116Combined sources
Beta strandi274 – 2807Combined sources
Turni281 – 2844Combined sources
Beta strandi285 – 2917Combined sources
Helixi297 – 2993Combined sources
Beta strandi301 – 3088Combined sources
Beta strandi311 – 3166Combined sources
Beta strandi321 – 3255Combined sources
Beta strandi328 – 3358Combined sources
Beta strandi342 – 3465Combined sources
Turni347 – 3504Combined sources
Beta strandi351 – 3544Combined sources
Beta strandi359 – 3613Combined sources
Turni362 – 3654Combined sources
Beta strandi366 – 3683Combined sources
Beta strandi375 – 3795Combined sources
Beta strandi387 – 3904Combined sources
Turni391 – 3933Combined sources
Beta strandi394 – 3974Combined sources
Beta strandi400 – 4045Combined sources
Beta strandi409 – 4146Combined sources
Beta strandi416 – 4249Combined sources
Beta strandi427 – 4337Combined sources
Turni434 – 4363Combined sources
Beta strandi439 – 4446Combined sources
Beta strandi449 – 4546Combined sources
Beta strandi456 – 4638Combined sources
Turni464 – 4663Combined sources
Beta strandi469 – 4735Combined sources
Beta strandi476 – 4827Combined sources
Beta strandi491 – 4966Combined sources
Beta strandi500 – 5078Combined sources
Beta strandi512 – 5165Combined sources
Turni517 – 5204Combined sources
Beta strandi521 – 5244Combined sources
Beta strandi534 – 5396Combined sources
Beta strandi555 – 5606Combined sources
Beta strandi565 – 5717Combined sources
Beta strandi577 – 5793Combined sources
Beta strandi587 – 5948Combined sources
Beta strandi597 – 6026Combined sources
Beta strandi607 – 6126Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PGUX-ray2.30A/B1-615[»]
1PI6X-ray2.50A1-615[»]
ProteinModelPortaliP46680.
SMRiP46680. Positions 2-615.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 4544WD 1PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati46 – 9449WD 2PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati95 – 14652WD 3PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati147 – 18943WD 4PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati190 – 23546WD 5PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati236 – 28045WD 6PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati281 – 32545WD 7PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati326 – 36338WD 8PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati364 – 39936WD 9PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati400 – 43334WD 10PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati434 – 47340WD 11PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati474 – 51643WD 12PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati517 – 56953WD 13PROSITE-ProRule annotation1 PublicationAdd
BLAST
Repeati570 – 61142WD 14PROSITE-ProRule annotation1 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi363 – 3664Poly-Ser

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
InParanoidiP46680.
OMAiACINELT.
OrthoDBiEOG092C1AB2.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSISLKEII PPQPSTQRNF TTHLSYDPTT NAIAYPCGKS AFVRCLDDGD
60 70 80 90 100
SKVPPVVQFT GHGSSVVTTV KFSPIKGSQY LCSGDESGKV IVWGWTFDKE
110 120 130 140 150
SNSVEVNVKS EFQVLAGPIS DISWDFEGRR LCVVGEGRDN FGVFISWDSG
160 170 180 190 200
NSLGEVSGHS QRINACHLKQ SRPMRSMTVG DDGSVVFYQG PPFKFSASDR
210 220 230 240 250
THHKQGSFVR DVEFSPDSGE FVITVGSDRK ISCFDGKSGE FLKYIEDDQE
260 270 280 290 300
PVQGGIFALS WLDSQKFATV GADATIRVWD VTTSKCVQKW TLDKQQLGNQ
310 320 330 340 350
QVGVVATGNG RIISLSLDGT LNFYELGHDE VLKTISGHNK GITALTVNPL
360 370 380 390 400
ISGSYDGRIM EWSSSSMHQD HSNLIVSLDN SKAQEYSSIS WDDTLKVNGI
410 420 430 440 450
TKHEFGSQPK VASANNDGFT AVLTNDDDLL ILQSFTGDII KSVRLNSPGS
460 470 480 490 500
AVSLSQNYVA VGLEEGNTIQ VFKLSDLEVS FDLKTPLRAK PSYISISPSE
510 520 530 540 550
TYIAAGDVMG KILLYDLQSR EVKTSRWAFH TSKINAISWK PAEKGANEEE
560 570 580 590 600
IEEDLVATGS LDTNIFIYSV KRPMKIIKAL NAHKDGVNNL LWETPSTLVS
610
SGADACIKRW NVVLE
Length:615
Mass (Da):67,326
Last modified:November 1, 1995 - v1
Checksum:iB8340BF68DD08257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35666 Genomic DNA. Translation: AAA79141.1.
Z49259 Genomic DNA. Translation: CAA89239.1.
BK006946 Genomic DNA. Translation: DAA09989.1.
PIRiS54468.
RefSeqiNP_013810.1. NM_001182592.1.

Genome annotation databases

EnsemblFungiiYMR092C; YMR092C; YMR092C.
GeneIDi855117.
KEGGisce:YMR092C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35666 Genomic DNA. Translation: AAA79141.1.
Z49259 Genomic DNA. Translation: CAA89239.1.
BK006946 Genomic DNA. Translation: DAA09989.1.
PIRiS54468.
RefSeqiNP_013810.1. NM_001182592.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PGUX-ray2.30A/B1-615[»]
1PI6X-ray2.50A1-615[»]
ProteinModelPortaliP46680.
SMRiP46680. Positions 2-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35267. 34 interactions.
DIPiDIP-890N.
IntActiP46680. 7 interactions.
MINTiMINT-399089.

PTM databases

iPTMnetiP46680.

Proteomic databases

MaxQBiP46680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR092C; YMR092C; YMR092C.
GeneIDi855117.
KEGGisce:YMR092C.

Organism-specific databases

EuPathDBiFungiDB:YMR092C.
SGDiS000004698. AIP1.

Phylogenomic databases

GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
InParanoidiP46680.
OMAiACINELT.
OrthoDBiEOG092C1AB2.

Enzyme and pathway databases

BioCyciYEAST:G3O-32792-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Miscellaneous databases

EvolutionaryTraceiP46680.
PROiP46680.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIP1_YEAST
AccessioniPrimary (citable) accession number: P46680
Secondary accession number(s): D6VZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.