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Protein

Transcription factor TFIIIB component B''

Gene

BDP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

General activator of RNA polymerase III transcription.

GO - Molecular functioni

  • DNA binding Source: InterPro
  • TFIIIB-type transcription factor activity Source: SGD
  • TFIIIC-class transcription factor binding Source: SGD

GO - Biological processi

  • DNA-templated transcriptional open complex formation Source: SGD
  • positive regulation of transposon integration Source: SGD
  • regulation of transcription, DNA-templated Source: MGI
  • RNA polymerase III transcriptional preinitiation complex assembly Source: SGD
  • transcription elongation from RNA polymerase III promoter Source: Reactome
  • transcription from RNA polymerase III promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33075-MONOMER.
ReactomeiR-SCE-73780. RNA Polymerase III Chain Elongation.
R-SCE-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-SCE-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-SCE-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-SCE-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TFIIIB component B''
Alternative name(s):
TFIIIB90
Gene namesi
Name:BDP1
Synonyms:TFC5
Ordered Locus Names:YNL039W
ORF Names:N2682
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL039W.
SGDiS000004984. BDP1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • transcription factor TFIIIB complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724981 – 594Transcription factor TFIIIB component B''Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP46678.
PRIDEiP46678.

PTM databases

iPTMnetiP46678.

Interactioni

Subunit structurei

TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and the B" component (BDP1). Interacts with TFC4.2 Publications

GO - Molecular functioni

  • TFIIIC-class transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi35785. 25 interactors.
DIPiDIP-964N.
IntActiP46678. 6 interactors.
MINTiMINT-477265.

Structurei

3D structure databases

ProteinModelPortaliP46678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini415 – 466SANTAdd BLAST52

Sequence similaritiesi

Belongs to the TFC5 family.Curated
Contains 1 SANT domain.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012762.
HOGENOMiHOG000066069.
KOiK15198.
OMAiNEERKHP.
OrthoDBiEOG092C5UXM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017174. Bdp1_fungi.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR030701. TFIIIB_B''.
[Graphical view]
PANTHERiPTHR22929. PTHR22929. 1 hit.
PIRSFiPIRSF037327. TFIIIB_Bdp1_fun. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

P46678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIVNKSGT RFAPKVRQRR AATGGTPTPK PRTPQLFIPE SKEIEEDNSD
60 70 80 90 100
NDKGVDENET AIVEKPSLVG ERSLEGFTLT GTNGHDNEIG DEGPIDASTQ
110 120 130 140 150
NPKADVIEDN VTLKPAPLQT HRDQKVPRSS RLASLSKDNE SRPSFKPSFL
160 170 180 190 200
DSSSNSNGTA RRLSTISNKL PKKIRLGSIT ENDMNLKTFK RHRVLGKPSS
210 220 230 240 250
AKKPAGAHRI SIVSKISPPT AMTDSLDRNE FSSETSTSRE ADENENYVIS
260 270 280 290 300
KVKDIPKKVR DGESAKYFID EENFTMAELC KPNFPIGQIS ENFEKSKMAK
310 320 330 340 350
KAKLEKRRHL RELRMRARQE FKPLHSLTKE EQEEEEEKRK EERDKLLNAD
360 370 380 390 400
IPESDRKAHT AIQLKLNPDG TMAIDEETMV VDRHKNASIE NEYKEKVDEN
410 420 430 440 450
PFANLYNYGS YGRGSYTDPW TVEEMIKFYK ALSMWGTDFN LISQLYPYRS
460 470 480 490 500
RKQVKAKFVN EEKKRPILIE LALRSKLPPN FDEYCCEIKK NIGTVADFNE
510 520 530 540 550
KLIELQNEHK HHMKEIEEAK NTAKEEDQTA QRLNDANLNK KGSGGIMTND
560 570 580 590
LKVYRKTEVV LGTIDDLKRK KLKERNNDDN EDNEGSEEEP EIDQ
Length:594
Mass (Da):67,688
Last modified:November 1, 1995 - v1
Checksum:i7B0115BBB2491175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31819 Genomic DNA. Translation: AAC49073.1.
U38415 Genomic DNA. Translation: AAC49364.1.
U37533 Genomic DNA. Translation: AAC49348.1.
Z71315 Genomic DNA. Translation: CAA95906.1.
BK006947 Genomic DNA. Translation: DAA10506.1.
PIRiS62141.
RefSeqiNP_014359.3. NM_001182878.3.

Genome annotation databases

EnsemblFungiiYNL039W; YNL039W; YNL039W.
GeneIDi855689.
KEGGisce:YNL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31819 Genomic DNA. Translation: AAC49073.1.
U38415 Genomic DNA. Translation: AAC49364.1.
U37533 Genomic DNA. Translation: AAC49348.1.
Z71315 Genomic DNA. Translation: CAA95906.1.
BK006947 Genomic DNA. Translation: DAA10506.1.
PIRiS62141.
RefSeqiNP_014359.3. NM_001182878.3.

3D structure databases

ProteinModelPortaliP46678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35785. 25 interactors.
DIPiDIP-964N.
IntActiP46678. 6 interactors.
MINTiMINT-477265.

PTM databases

iPTMnetiP46678.

Proteomic databases

MaxQBiP46678.
PRIDEiP46678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL039W; YNL039W; YNL039W.
GeneIDi855689.
KEGGisce:YNL039W.

Organism-specific databases

EuPathDBiFungiDB:YNL039W.
SGDiS000004984. BDP1.

Phylogenomic databases

GeneTreeiENSGT00390000012762.
HOGENOMiHOG000066069.
KOiK15198.
OMAiNEERKHP.
OrthoDBiEOG092C5UXM.

Enzyme and pathway databases

BioCyciYEAST:G3O-33075-MONOMER.
ReactomeiR-SCE-73780. RNA Polymerase III Chain Elongation.
R-SCE-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-SCE-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-SCE-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-SCE-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

PROiP46678.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017174. Bdp1_fungi.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR030701. TFIIIB_B''.
[Graphical view]
PANTHERiPTHR22929. PTHR22929. 1 hit.
PIRSFiPIRSF037327. TFIIIB_Bdp1_fun. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTFC5_YEAST
AccessioniPrimary (citable) accession number: P46678
Secondary accession number(s): D6W1E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.