P46671 (FAR3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Factor arrest protein 3

Gene names

Name:	FAR3
Ordered Locus Names:	YMR052W
ORF Names:	YM9796.05

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the control of the reentry into the cell cycle following pheromone treatment. Ref.4
Subunit structure	Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
Subcellular location	Endoplasmic reticulum Ref.5.
Miscellaneous	Present with 1540 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Endoplasmic reticulum
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	re-entry into mitotic cell cycle after pheromone arrest Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FAR7	P43592	4	EBI-6789,EBI-22932

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Factor arrest protein 3		PRO_0000087191
Experimental info
	Sequence conflict	6	1	S → T in AAB39035. Ref.1
	Sequence conflict	131	1	S → T in AAB39035. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46671 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: DCDA9A5713B588B5	FASTA	204	24,032
	10 20 30 40 50 60 MNSGGSDSFD YLLQLTKALS AECRANRQET DRIELLLKRL AKQSGISYDN LSKNIIPDSW 70 80 90 100 110 120 KDNASQKASP PTEAQKLISE NFKLIYEIEK QEYFNTKAVA LINNINEHFS YIKNFIDEQN 130 140 150 160 170 180 AIRERNIATF SSEKLDERNK SLQQNYESLK TENEETKKKL HSIIKQFEKL LKEVDWDRIS 190 200 KDSRDYSRFK KQLEYLQDTY QVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization of the FAR3 gene: genetic mapping and molecular cloning using a chromosome walk-'n'-roll strategy." Horecka J. Yeast 11:691-696(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC252.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae." Kemp H.A., Sprague G.F. Jr. Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FAR7; FAR8; FAR10; FAR11 AND VPS64.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U35609 Genomic DNA. Translation: AAB39035.1. Z49703 Genomic DNA. Translation: CAA89762.1. BK006946 Genomic DNA. Translation: DAA09951.1.
PIR	S54552.
RefSeq	NP_013767.1. NM_001182550.1.
3D structure databases
ProteinModelPortal	P46671.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1314N.
IntAct	P46671. 6 interactions.
MINT	MINT-393191.
STRING	4932.YMR052W.
Proteomic databases
PaxDb	P46671.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR052W; YMR052W; YMR052W.
GeneID	855073.
KEGG	sce:YMR052W.
Organism-specific databases
CYGD	YMR052w.
SGD	S000004656. FAR3.
Phylogenomic databases
eggNOG	NOG44390.
HOGENOM	HOG000112501.
OMA	NDGHINA.
OrthoDB	EOG412QG6.
Gene expression databases
Genevestigator	P46671.
GermOnline	YMR052W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	978348.

Entry information

Entry name

FAR3_YEAST

Accession

Primary (citable) accession number: P46671
Secondary accession number(s): D6VZM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program