Reviewed, UniProtKB/Swiss-Prot P46671 (FAR3_YEAST)

Names and origin

Protein names

Recommended name:
    Factor arrest protein 3

Gene names

Name:	FAR3
Ordered Locus Names:	YMR052W
ORF Names:	YM9796.05

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Participates in the control of the reentry into the cell cycle following pheromone treatment. Ref.3
Subunit structure	Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
Subcellular location	Endoplasmic reticulum.
Miscellaneous	Present with 1540 molecules/cell in log phase SD medium. Ref.5

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Endoplasmic reticulum
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	re-entry into mitotic cell cycle after pheromone arrest Ref.3 Inferred from genetic interaction. Source: SGD
Cellular component	endoplasmic reticulum Ref.4 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FAR7	P43592	4	EBI-6789,EBI-22932
VPS64	Q03944	2	EBI-6789,EBI-30418

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Factor arrest protein 3		PRO_0000087191
Experimental info
	Sequence conflict	6	1	S → T in AAB39035. Ref.1
	Sequence conflict	131	1	S → T in AAB39035. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46671-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: DCDA9A5713B588B5	FASTA	204	24,032
	10 20 30 40 50 60 MNSGGSDSFD YLLQLTKALS AECRANRQET DRIELLLKRL AKQSGISYDN LSKNIIPDSW 70 80 90 100 110 120 KDNASQKASP PTEAQKLISE NFKLIYEIEK QEYFNTKAVA LINNINEHFS YIKNFIDEQN 130 140 150 160 170 180 AIRERNIATF SSEKLDERNK SLQQNYESLK TENEETKKKL HSIIKQFEKL LKEVDWDRIS 190 200 KDSRDYSRFK KQLEYLQDTY QVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization of the FAR3 gene: genetic mapping and molecular cloning using a chromosome walk-'n'-roll strategy." Horecka J. Yeast 11:691-696(1995) [PubMed: 7483842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC252.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae." Kemp H.A., Sprague G.F. Jr. Mol. Cell. Biol. 23:1750-1763(2003) [PubMed: 12588993] [Abstract] Cited for: FUNCTION, INTERACTION WITH FAR7; FAR8; FAR10; FAR11 AND VPS64.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U35609 Genomic DNA. Translation: AAB39035.1. Z49703 Genomic DNA. Translation: CAA89762.1.
PIR	S54552.
RefSeq	NP_013767.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1314N.
IntAct	P46671. 13 interactions.
STRING	P46671.
Genome annotation databases
Ensembl	YMR052W; YMR052W; YMR052W; Saccharomyces cerevisiae. [Genome view]
GeneID	855073.
KEGG	sce:YMR052W.
NMPDR	fig|4932.3.peg.4814.
Organism-specific databases
CYGD	YMR052w.
SGD	S000004656. FAR3.
Phylogenomic databases
HOGENOM	P46671.
OMA	NDGHINA
OrthoDB	EOG9KSR2X
Gene expression databases
ArrayExpress	P46671.
Genevestigator	P46671.
GermOnline	YMR052W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	978348.

Entry information

Entry name

FAR3_YEAST

Accession

Primary (citable) accession number: P46671

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)