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P46670

- TBCC_YEAST

UniProt

P46670 - TBCC_YEAST

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Protein

Tubulin-specific chaperone C

Gene

CIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

GO - Molecular functioni

  1. GTPase activator activity Source: SGD

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. protein folding Source: SGD
  3. tubulin complex assembly Source: SGD
  4. tubulin complex biogenesis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-34127-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone C
Alternative name(s):
Chromosome instability protein 2
Tubulin-folding cofactor C
Gene namesi
Name:CIN2
Ordered Locus Names:YPL241C
ORF Names:P1043
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL241c.
SGDiS000006162. CIN2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Tubulin-specific chaperone CPRO_0000089762Add
BLAST

Proteomic databases

MaxQBiP46670.
PaxDbiP46670.

Expressioni

Gene expression databases

GenevestigatoriP46670.

Interactioni

Protein-protein interaction databases

BioGridi35922. 125 interactions.
DIPiDIP-3960N.
MINTiMINT-488757.
STRINGi4932.YPL241C.

Structurei

3D structure databases

ProteinModelPortaliP46670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 255158C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47016.
InParanoidiP46670.
OMAiTEDNSAF.
OrthoDBiEOG78D7ZQ.

Family and domain databases

InterProiIPR017901. C-CAP_CF_C-like.
[Graphical view]
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46670-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS
60 70 80 90 100
NDIENVLKSI NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY
110 120 130 140 150
TTTLKKHYVL EKGDSAFENL EFCTVTSTTD YSGNSALSGS LCFRNITKCV
160 170 180 190 200
INLQRIFFQT GSIFITDCTD SIIFLRSPSD KDFQIRLRDL KNCKILIEKL
210 220 230 240 250
SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE ETEDNSAFAF
260
EDFDICNKDT MQLFRAYL
Length:268
Mass (Da):30,709
Last modified:May 15, 2002 - v2
Checksum:iCE9F2DB6B76997A8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661E → Y in AAA78272. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34961 Genomic DNA. Translation: AAA78272.1.
Z73597 Genomic DNA. Translation: CAA97962.1.
BK006949 Genomic DNA. Translation: DAA11196.1.
PIRiS65270.
RefSeqiNP_015083.1. NM_001184055.1.

Genome annotation databases

EnsemblFungiiYPL241C; YPL241C; YPL241C.
GeneIDi855835.
KEGGisce:YPL241C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34961 Genomic DNA. Translation: AAA78272.1 .
Z73597 Genomic DNA. Translation: CAA97962.1 .
BK006949 Genomic DNA. Translation: DAA11196.1 .
PIRi S65270.
RefSeqi NP_015083.1. NM_001184055.1.

3D structure databases

ProteinModelPortali P46670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35922. 125 interactions.
DIPi DIP-3960N.
MINTi MINT-488757.
STRINGi 4932.YPL241C.

Proteomic databases

MaxQBi P46670.
PaxDbi P46670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL241C ; YPL241C ; YPL241C .
GeneIDi 855835.
KEGGi sce:YPL241C.

Organism-specific databases

CYGDi YPL241c.
SGDi S000006162. CIN2.

Phylogenomic databases

eggNOGi NOG47016.
InParanoidi P46670.
OMAi TEDNSAF.
OrthoDBi EOG78D7ZQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-34127-MONOMER.

Miscellaneous databases

NextBioi 980404.

Gene expression databases

Genevestigatori P46670.

Family and domain databases

InterProi IPR017901. C-CAP_CF_C-like.
[Graphical view ]
PROSITEi PS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Stearns T., Kwon D., Shin K.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTBCC_YEAST
AccessioniPrimary (citable) accession number: P46670
Secondary accession number(s): D6W3D0, Q08973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 15, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3