Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubulin-specific chaperone C

Gene

CIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

GO - Molecular functioni

  • GTPase activator activity Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-34127-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone C
Alternative name(s):
Chromosome instability protein 2
Tubulin-folding cofactor C
Gene namesi
Name:CIN2
Ordered Locus Names:YPL241C
ORF Names:P1043
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL241C.
SGDiS000006162. CIN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897621 – 268Tubulin-specific chaperone CAdd BLAST268

Proteomic databases

MaxQBiP46670.
PRIDEiP46670.

Interactioni

Protein-protein interaction databases

BioGridi35922. 125 interactors.
DIPiDIP-3960N.
MINTiMINT-488757.

Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi103 – 105Combined sources3
Beta strandi107 – 110Combined sources4
Beta strandi116 – 122Combined sources7
Beta strandi124 – 127Combined sources4
Beta strandi136 – 148Combined sources13
Beta strandi150 – 154Combined sources5
Beta strandi157 – 170Combined sources14
Beta strandi172 – 177Combined sources6
Beta strandi184 – 192Combined sources9
Beta strandi194 – 199Combined sources6
Beta strandi208 – 214Combined sources7
Beta strandi216 – 221Combined sources6
Helixi222 – 227Combined sources6
Beta strandi228 – 232Combined sources5
Beta strandi248 – 251Combined sources4
Helixi256 – 258Combined sources3
Helixi260 – 267Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CYAX-ray2.00A/B1-268[»]
ProteinModelPortaliP46670.
SMRiP46670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 255C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP46670.
OMAiLANHEST.
OrthoDBiEOG092C5WJK.

Family and domain databases

InterProiIPR017901. C-CAP_CF_C-like.
[Graphical view]
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS
60 70 80 90 100
NDIENVLKSI NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY
110 120 130 140 150
TTTLKKHYVL EKGDSAFENL EFCTVTSTTD YSGNSALSGS LCFRNITKCV
160 170 180 190 200
INLQRIFFQT GSIFITDCTD SIIFLRSPSD KDFQIRLRDL KNCKILIEKL
210 220 230 240 250
SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE ETEDNSAFAF
260
EDFDICNKDT MQLFRAYL
Length:268
Mass (Da):30,709
Last modified:May 15, 2002 - v2
Checksum:iCE9F2DB6B76997A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66E → Y in AAA78272 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34961 Genomic DNA. Translation: AAA78272.1.
Z73597 Genomic DNA. Translation: CAA97962.1.
BK006949 Genomic DNA. Translation: DAA11196.1.
PIRiS65270.
RefSeqiNP_015083.1. NM_001184055.1.

Genome annotation databases

EnsemblFungiiYPL241C; YPL241C; YPL241C.
GeneIDi855835.
KEGGisce:YPL241C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34961 Genomic DNA. Translation: AAA78272.1.
Z73597 Genomic DNA. Translation: CAA97962.1.
BK006949 Genomic DNA. Translation: DAA11196.1.
PIRiS65270.
RefSeqiNP_015083.1. NM_001184055.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CYAX-ray2.00A/B1-268[»]
ProteinModelPortaliP46670.
SMRiP46670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35922. 125 interactors.
DIPiDIP-3960N.
MINTiMINT-488757.

Proteomic databases

MaxQBiP46670.
PRIDEiP46670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL241C; YPL241C; YPL241C.
GeneIDi855835.
KEGGisce:YPL241C.

Organism-specific databases

EuPathDBiFungiDB:YPL241C.
SGDiS000006162. CIN2.

Phylogenomic databases

InParanoidiP46670.
OMAiLANHEST.
OrthoDBiEOG092C5WJK.

Enzyme and pathway databases

BioCyciYEAST:G3O-34127-MONOMER.

Miscellaneous databases

PROiP46670.

Family and domain databases

InterProiIPR017901. C-CAP_CF_C-like.
[Graphical view]
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCC_YEAST
AccessioniPrimary (citable) accession number: P46670
Secondary accession number(s): D6W3D0, Q08973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 15, 2002
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.