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P46670

- TBCC_YEAST

UniProt

P46670 - TBCC_YEAST

Protein

Tubulin-specific chaperone C

Gene

CIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (15 May 2002)
      Previous versions | rss
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    Functioni

    Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

    GO - Molecular functioni

    1. GTPase activator activity Source: SGD

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. protein folding Source: SGD
    3. tubulin complex assembly Source: SGD
    4. tubulin complex biogenesis Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34127-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulin-specific chaperone C
    Alternative name(s):
    Chromosome instability protein 2
    Tubulin-folding cofactor C
    Gene namesi
    Name:CIN2
    Ordered Locus Names:YPL241C
    ORF Names:P1043
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL241c.
    SGDiS000006162. CIN2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Tubulin-specific chaperone CPRO_0000089762Add
    BLAST

    Proteomic databases

    MaxQBiP46670.
    PaxDbiP46670.

    Expressioni

    Gene expression databases

    GenevestigatoriP46670.

    Interactioni

    Protein-protein interaction databases

    BioGridi35922. 124 interactions.
    DIPiDIP-3960N.
    MINTiMINT-488757.
    STRINGi4932.YPL241C.

    Structurei

    3D structure databases

    ProteinModelPortaliP46670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini98 – 255158C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG47016.
    OMAiTEDNSAF.
    OrthoDBiEOG78D7ZQ.

    Family and domain databases

    InterProiIPR017901. C-CAP_CF_C-like.
    [Graphical view]
    PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46670-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS    50
    NDIENVLKSI NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY 100
    TTTLKKHYVL EKGDSAFENL EFCTVTSTTD YSGNSALSGS LCFRNITKCV 150
    INLQRIFFQT GSIFITDCTD SIIFLRSPSD KDFQIRLRDL KNCKILIEKL 200
    SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE ETEDNSAFAF 250
    EDFDICNKDT MQLFRAYL 268
    Length:268
    Mass (Da):30,709
    Last modified:May 15, 2002 - v2
    Checksum:iCE9F2DB6B76997A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661E → Y in AAA78272. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34961 Genomic DNA. Translation: AAA78272.1.
    Z73597 Genomic DNA. Translation: CAA97962.1.
    BK006949 Genomic DNA. Translation: DAA11196.1.
    PIRiS65270.
    RefSeqiNP_015083.1. NM_001184055.1.

    Genome annotation databases

    EnsemblFungiiYPL241C; YPL241C; YPL241C.
    GeneIDi855835.
    KEGGisce:YPL241C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34961 Genomic DNA. Translation: AAA78272.1 .
    Z73597 Genomic DNA. Translation: CAA97962.1 .
    BK006949 Genomic DNA. Translation: DAA11196.1 .
    PIRi S65270.
    RefSeqi NP_015083.1. NM_001184055.1.

    3D structure databases

    ProteinModelPortali P46670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35922. 124 interactions.
    DIPi DIP-3960N.
    MINTi MINT-488757.
    STRINGi 4932.YPL241C.

    Proteomic databases

    MaxQBi P46670.
    PaxDbi P46670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL241C ; YPL241C ; YPL241C .
    GeneIDi 855835.
    KEGGi sce:YPL241C.

    Organism-specific databases

    CYGDi YPL241c.
    SGDi S000006162. CIN2.

    Phylogenomic databases

    eggNOGi NOG47016.
    OMAi TEDNSAF.
    OrthoDBi EOG78D7ZQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34127-MONOMER.

    Miscellaneous databases

    NextBioi 980404.

    Gene expression databases

    Genevestigatori P46670.

    Family and domain databases

    InterProi IPR017901. C-CAP_CF_C-like.
    [Graphical view ]
    PROSITEi PS51329. C_CAP_COFACTOR_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Stearns T., Kwon D., Shin K.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTBCC_YEAST
    AccessioniPrimary (citable) accession number: P46670
    Secondary accession number(s): D6W3D0, Q08973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 15, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1630 molecules/cell.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3