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P46670 (TBCC_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tubulin-specific chaperone C
Alternative name(s):
Chromosome instability protein 2
Tubulin-folding cofactor C
Gene names
Name:CIN2
Ordered Locus Names:YPL241C
ORF Names:P1043
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Subcellular location

Cytoplasmcytoskeleton.

Miscellaneous

Present with 1630 molecules/cell.

Sequence similarities

Contains 1 C-CAP/cofactor C-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Tubulin-specific chaperone C
PRO_0000089762

Regions

Domain98 – 255158C-CAP/cofactor C-like

Experimental info

Sequence conflict661E → Y in AAA78272. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P46670 [UniParc].

Last modified May 15, 2002. Version 2.
Checksum: CE9F2DB6B76997A8

FASTA26830,709
        10         20         30         40         50         60 
MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS NDIENVLKSI 

        70         80         90        100        110        120 
NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY TTTLKKHYVL EKGDSAFENL 

       130        140        150        160        170        180 
EFCTVTSTTD YSGNSALSGS LCFRNITKCV INLQRIFFQT GSIFITDCTD SIIFLRSPSD 

       190        200        210        220        230        240 
KDFQIRLRDL KNCKILIEKL SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE 

       250        260 
ETEDNSAFAF EDFDICNKDT MQLFRAYL 

« Hide

References

« Hide 'large scale' references
[1]Stearns T., Kwon D., Shin K.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34961 Genomic DNA. Translation: AAA78272.1.
Z73597 Genomic DNA. Translation: CAA97962.1.
BK006949 Genomic DNA. Translation: DAA11196.1.
PIRS65270.
RefSeqNP_015083.1. NM_001184055.1.

3D structure databases

ProteinModelPortalP46670.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35922. 124 interactions.
DIPDIP-3960N.
MINTMINT-488757.
STRING4932.YPL241C.

Proteomic databases

PaxDbP46670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL241C; YPL241C; YPL241C.
GeneID855835.
KEGGsce:YPL241C.

Organism-specific databases

CYGDYPL241c.
SGDS000006162. CIN2.

Phylogenomic databases

eggNOGNOG47016.
OMAFNTICRE.
OrthoDBEOG78D7ZQ.

Enzyme and pathway databases

BioCycYEAST:G3O-34127-MONOMER.

Gene expression databases

GenevestigatorP46670.

Family and domain databases

InterProIPR017901. C-CAP_CF_C-like.
[Graphical view]
PROSITEPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980404.

Entry information

Entry nameTBCC_YEAST
AccessionPrimary (citable) accession number: P46670
Secondary accession number(s): D6W3D0, Q08973
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 15, 2002
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families