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Protein

Tubulin-specific chaperone C

Gene

CIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Miscellaneous

Present with 1630 molecules/cell.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD

GO - Biological processi

  • post-chaperonin tubulin folding pathway Source: InterPro
  • protein folding Source: SGD
  • tubulin complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-34127-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone C
Alternative name(s):
Chromosome instability protein 2
Tubulin-folding cofactor C
Gene namesi
Name:CIN2
Ordered Locus Names:YPL241C
ORF Names:P1043
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL241C
SGDiS000006162 CIN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897621 – 268Tubulin-specific chaperone CAdd BLAST268

Proteomic databases

MaxQBiP46670
PaxDbiP46670
PRIDEiP46670

Interactioni

Protein-protein interaction databases

BioGridi35922, 209 interactors
DIPiDIP-3960N
IntActiP46670, 4 interactors
STRINGi4932.YPL241C

Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi103 – 105Combined sources3
Beta strandi107 – 110Combined sources4
Beta strandi116 – 122Combined sources7
Beta strandi124 – 127Combined sources4
Beta strandi136 – 148Combined sources13
Beta strandi150 – 154Combined sources5
Beta strandi157 – 170Combined sources14
Beta strandi172 – 177Combined sources6
Beta strandi184 – 192Combined sources9
Beta strandi194 – 199Combined sources6
Beta strandi208 – 214Combined sources7
Beta strandi216 – 221Combined sources6
Helixi222 – 227Combined sources6
Beta strandi228 – 232Combined sources5
Beta strandi248 – 251Combined sources4
Helixi256 – 258Combined sources3
Helixi260 – 267Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CYAX-ray2.00A/B1-268[»]
DisProtiDP00778
ProteinModelPortaliP46670
SMRiP46670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 255C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST158

Phylogenomic databases

InParanoidiP46670
KOiK21766
OMAiCEPWITI
OrthoDBiEOG092C5WJK

Family and domain databases

Gene3Di2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR027684 TBCC
PANTHERiPTHR15139 PTHR15139, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit

Sequencei

Sequence statusi: Complete.

P46670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS
60 70 80 90 100
NDIENVLKSI NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY
110 120 130 140 150
TTTLKKHYVL EKGDSAFENL EFCTVTSTTD YSGNSALSGS LCFRNITKCV
160 170 180 190 200
INLQRIFFQT GSIFITDCTD SIIFLRSPSD KDFQIRLRDL KNCKILIEKL
210 220 230 240 250
SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE ETEDNSAFAF
260
EDFDICNKDT MQLFRAYL
Length:268
Mass (Da):30,709
Last modified:May 15, 2002 - v2
Checksum:iCE9F2DB6B76997A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66E → Y in AAA78272 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34961 Genomic DNA Translation: AAA78272.1
Z73597 Genomic DNA Translation: CAA97962.1
BK006949 Genomic DNA Translation: DAA11196.1
PIRiS65270
RefSeqiNP_015083.1, NM_001184055.1

Genome annotation databases

EnsemblFungiiYPL241C; YPL241C; YPL241C
GeneIDi855835
KEGGisce:YPL241C

Similar proteinsi

Entry informationi

Entry nameiTBCC_YEAST
AccessioniPrimary (citable) accession number: P46670
Secondary accession number(s): D6W3D0, Q08973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 15, 2002
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health