P46663 (BKRB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B1 bradykinin receptor
Short name=B1R
Short name=BK-1 receptor

Gene names

Name:	BDKRB1
Synonyms:	BRADYB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of leukocyte migration Inferred from electronic annotation. Source: Compara positive regulation of release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum Traceable author statement PubMed 9930991. Source: ProtInc integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc neuron projection Inferred from electronic annotation. Source: Compara
Molecular_function	bradykinin receptor activity Traceable author statement Ref.4. Source: ProtInc peptide binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	B1 bradykinin receptor		PRO_0000069181
Regions
	Topological domain	1 – 40	40	Extracellular Potential
	Transmembrane	41 – 64	24	Helical; Name=1; Potential
	Topological domain	65 – 73	9	Cytoplasmic Potential
	Transmembrane	74 – 98	25	Helical; Name=2; Potential
	Topological domain	99 – 111	13	Extracellular Potential
	Transmembrane	112 – 133	22	Helical; Name=3; Potential
	Topological domain	134 – 155	22	Cytoplasmic Potential
	Transmembrane	156 – 178	23	Helical; Name=4; Potential
	Topological domain	179 – 199	21	Extracellular Potential
	Transmembrane	200 – 226	27	Helical; Name=5; Potential
	Topological domain	227 – 247	21	Cytoplasmic Potential
	Transmembrane	248 – 272	25	Helical; Name=6; Potential
	Topological domain	273 – 291	19	Extracellular Potential
	Transmembrane	292 – 314	23	Helical; Name=7; Potential
	Topological domain	315 – 353	39	Cytoplasmic Potential
Amino acid modifications
	Lipidation	330	1	S-palmitoyl cysteine Potential
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	185	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 189		By similarity
Natural variations
	Natural variant	250	1	A → V. Corresponds to variant rs2229459 [ dbSNP | Ensembl ].		VAR_014359
	Natural variant	317	1	R → Q. Corresponds to variant rs8004609 [ dbSNP | Ensembl ].		VAR_049376
Experimental info
	Sequence conflict	146	1	R → G Ref.1
	Sequence conflict	146	1	R → G Ref.2
	Sequence conflict	146	1	R → G Ref.3
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.1
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.2
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.3
	Sequence conflict	246	1	S → R Ref.2
	Sequence conflict	259	1	F → S in AAC50594. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P46663 [UniParc]. Last modified January 10, 2006. Version 3. Checksum: B62B0690A7593077	FASTA	353	40,495
	10 20 30 40 50 60 MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 70 80 90 100 110 120 VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 130 140 150 160 170 180 LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 190 200 210 220 230 240 VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 250 260 270 280 290 300 GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 310 320 330 340 350 AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a human B1 bradykinin receptor." Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F. J. Biol. Chem. 269:21583-21586(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions." Yang X., Polgar P. Biochem. Biophys. Res. Commun. 222:718-725(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)." Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F. Genomics 33:374-381(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Molecular characterisation of cloned bradykinin B1 receptors from rat and human." Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P. Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[5]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Isolation of complete coding sequence for bradykinin receptor B1 (BDKRB1)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Web resources

Wikipedia

Bradykinin receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12512 mRNA. Translation: AAA21346.1. U22346 Genomic DNA. Translation: AAC50594.1. U48231 Genomic DNA. Translation: AAB60693.1. AJ238044 mRNA. Translation: CAB45650.1. AB065896 Genomic DNA. Translation: BAC06112.1. AY275464 Genomic DNA. Translation: AAP32296.1. AK291970 mRNA. Translation: BAF84659.1. CH471061 Genomic DNA. Translation: EAW81632.1. BC034705 mRNA. Translation: AAH34705.1.
IPI	IPI00296538.
PIR	A53858.
RefSeq	NP_000701.2. NM_000710.3.
UniGene	Hs.525572.
3D structure databases
ProteinModelPortal	P46663.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000216629.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	85681914.
Proteomic databases
PaxDb	P46663.
PRIDE	P46663.
Protocols and materials databases
DNASU	623.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216629; ENSP00000216629; ENSG00000100739.
GeneID	623.
KEGG	hsa:623.
UCSC	uc001yfh.3. human.
Organism-specific databases
CTD	623.
GeneCards	GC14P096722.
HGNC	HGNC:1029. BDKRB1.
HPA	HPA002935.
MIM	600337. gene.
neXtProt	NX_P46663.
PharmGKB	PA79.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327312.
HOGENOM	HOG000010314.
HOVERGEN	HBG103183.
InParanoid	P46663.
KO	K03915.
OMA	PYHFFAF.
OrthoDB	EOG4WH8M4.
PhylomeDB	P46663.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P46663.
Bgee	P46663.
CleanEx	HS_BDKRB1.
Genevestigator	P46663.
GermOnline	ENSG00000100739. Homo sapiens.
Family and domain databases
InterPro	IPR001186. Brdyknn_1_rcpt. IPR000496. Brdyknn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00425. BRADYKININR. PR00993. BRADYKINNB1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P46663.
ChEMBL	CHEMBL4308.
GenomeRNAi	623.
NextBio	2518.
SOURCE	Search...

Entry information

Entry name

BKRB1_HUMAN

Accession

Primary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 131 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.