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P46663

- BKRB1_HUMAN

UniProt

P46663 - BKRB1_HUMAN

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Protein

B1 bradykinin receptor

Gene
BDKRB1, BRADYB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  1. bradykinin receptor activity Source: ProtInc
  2. peptide binding Source: Ensembl
  3. protein binding Source: IntAct

GO - Biological processi

  1. cell migration Source: Ensembl
  2. inflammatory response Source: Ensembl
  3. negative regulation of blood pressure Source: Ensembl
  4. negative regulation of cell growth Source: Ensembl
  5. negative regulation of protein phosphorylation Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  7. positive regulation of leukocyte migration Source: Ensembl
  8. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  9. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  10. response to lipopolysaccharide Source: Ensembl
  11. response to mechanical stimulus Source: InterPro
  12. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
Synonyms:BRADYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1029. BDKRB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Extracellular Reviewed predictionAdd
BLAST
Transmembranei41 – 6424Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini65 – 739Cytoplasmic Reviewed prediction
Transmembranei74 – 9825Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini99 – 11113Extracellular Reviewed predictionAdd
BLAST
Transmembranei112 – 13322Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini134 – 15522Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei156 – 17823Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini179 – 19921Extracellular Reviewed predictionAdd
BLAST
Transmembranei200 – 22627Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini227 – 24721Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei248 – 27225Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini273 – 29119Extracellular Reviewed predictionAdd
BLAST
Transmembranei292 – 31423Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini315 – 35339Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
  2. integral component of plasma membrane Source: ProtInc
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA79.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353B1 bradykinin receptorPRO_0000069181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 189 By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Lipidationi330 – 3301S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP46663.
PRIDEiP46663.

Expressioni

Gene expression databases

BgeeiP46663.
CleanExiHS_BDKRB1.
GenevestigatoriP46663.

Organism-specific databases

HPAiHPA002935.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623218,EBI-6623250

Protein-protein interaction databases

BioGridi107092. 1 interaction.
IntActiP46663. 1 interaction.
STRINGi9606.ENSP00000216629.

Structurei

3D structure databases

ProteinModelPortaliP46663.
SMRiP46663. Positions 1-330.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327312.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP46663.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiP46663.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46663-1 [UniParc]FASTAAdd to Basket

« Hide

MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF    50
GLLGNLFVLL VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ 100
FNWPFGALLC RVINGVIKAN LFISIFLVVA ISQDRYRVLV HPMASRRQQR 150
RRQARVTCVL IWVVGGLLSI PTFLLRSIQA VPDLNITACI LLLPHEAWHF 200
ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC GGRKDSKTTA 250
LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 300
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF 350
WRN 353
Length:353
Mass (Da):40,495
Last modified:January 10, 2006 - v3
Checksum:iB62B0690A7593077
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501A → V.
Corresponds to variant rs2229459 [ dbSNP | Ensembl ].
VAR_014359
Natural varianti317 – 3171R → Q.
Corresponds to variant rs8004609 [ dbSNP | Ensembl ].
VAR_049376

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461R → G1 Publication
Sequence conflicti146 – 1461R → G1 Publication
Sequence conflicti146 – 1461R → G1 Publication
Sequence conflicti240 – 2434CGGR → VRGP1 Publication
Sequence conflicti240 – 2434CGGR → VRGP1 Publication
Sequence conflicti240 – 2434CGGR → VRGP1 Publication
Sequence conflicti246 – 2461S → R1 Publication
Sequence conflicti259 – 2591F → S in AAC50594. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
AK291970 mRNA. Translation: BAF84659.1.
CH471061 Genomic DNA. Translation: EAW81632.1.
BC034705 mRNA. Translation: AAH34705.1.
CCDSiCCDS9943.1.
PIRiA53858.
RefSeqiNP_000701.2. NM_000710.3.
UniGeneiHs.525572.

Genome annotation databases

EnsembliENST00000216629; ENSP00000216629; ENSG00000100739.
GeneIDi623.
KEGGihsa:623.
UCSCiuc001yfh.3. human.

Polymorphism databases

DMDMi85681914.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bradykinin receptor entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12512 mRNA. Translation: AAA21346.1 .
U22346 Genomic DNA. Translation: AAC50594.1 .
U48231 Genomic DNA. Translation: AAB60693.1 .
AJ238044 mRNA. Translation: CAB45650.1 .
AB065896 Genomic DNA. Translation: BAC06112.1 .
AY275464 Genomic DNA. Translation: AAP32296.1 .
AK291970 mRNA. Translation: BAF84659.1 .
CH471061 Genomic DNA. Translation: EAW81632.1 .
BC034705 mRNA. Translation: AAH34705.1 .
CCDSi CCDS9943.1.
PIRi A53858.
RefSeqi NP_000701.2. NM_000710.3.
UniGenei Hs.525572.

3D structure databases

ProteinModelPortali P46663.
SMRi P46663. Positions 1-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107092. 1 interaction.
IntActi P46663. 1 interaction.
STRINGi 9606.ENSP00000216629.

Chemistry

BindingDBi P46663.
ChEMBLi CHEMBL4308.
GuidetoPHARMACOLOGYi 41.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 85681914.

Proteomic databases

PaxDbi P46663.
PRIDEi P46663.

Protocols and materials databases

DNASUi 623.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216629 ; ENSP00000216629 ; ENSG00000100739 .
GeneIDi 623.
KEGGi hsa:623.
UCSCi uc001yfh.3. human.

Organism-specific databases

CTDi 623.
GeneCardsi GC14P096722.
HGNCi HGNC:1029. BDKRB1.
HPAi HPA002935.
MIMi 600337. gene.
neXtProti NX_P46663.
PharmGKBi PA79.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327312.
HOGENOMi HOG000010314.
HOVERGENi HBG103183.
InParanoidi P46663.
KOi K03915.
OMAi PYHFFAF.
OrthoDBi EOG7K9K36.
PhylomeDBi P46663.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Bradykinin_receptor_B1.
GenomeRNAii 623.
NextBioi 2518.
PROi P46663.
SOURCEi Search...

Gene expression databases

Bgeei P46663.
CleanExi HS_BDKRB1.
Genevestigatori P46663.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a human B1 bradykinin receptor."
    Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F.
    J. Biol. Chem. 269:21583-21586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions."
    Yang X., Polgar P.
    Biochem. Biophys. Res. Commun. 222:718-725(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)."
    Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.
    Genomics 33:374-381(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Molecular characterisation of cloned bradykinin B1 receptors from rat and human."
    Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P.
    Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Isolation of complete coding sequence for bradykinin receptor B1 (BDKRB1)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiBKRB1_HUMAN
AccessioniPrimary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: September 3, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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