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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  • bradykinin receptor activity Source: ProtInc
  • peptide binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP46663.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
Synonyms:BRADYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100739.10.
HGNCiHGNC:1029. BDKRB1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 64Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 98Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 199ExtracellularSequence analysisAdd BLAST21
Transmembranei200 – 226Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini227 – 247CytoplasmicSequence analysisAdd BLAST21
Transmembranei248 – 272Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini273 – 291ExtracellularSequence analysisAdd BLAST19
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 353CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi623.
OpenTargetsiENSG00000100739.
PharmGKBiPA79.

Chemistry databases

ChEMBLiCHEMBL4308.
GuidetoPHARMACOLOGYi41.

Polymorphism and mutation databases

BioMutaiBDKRB1.
DMDMi85681914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691811 – 353B1 bradykinin receptorAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 189PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi330S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP46663.
PeptideAtlasiP46663.
PRIDEiP46663.

PTM databases

iPTMnetiP46663.
PhosphoSitePlusiP46663.

Expressioni

Gene expression databases

BgeeiENSG00000100739.
CleanExiHS_BDKRB1.
ExpressionAtlasiP46663. baseline and differential.
GenevisibleiP46663. HS.

Organism-specific databases

HPAiHPA002935.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623218,EBI-6623250

Protein-protein interaction databases

IntActiP46663. 1 interactor.
STRINGi9606.ENSP00000216629.

Chemistry databases

BindingDBiP46663.

Structurei

3D structure databases

ProteinModelPortaliP46663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP46663.
KOiK03915.
OMAiFNCHILA.
OrthoDBiEOG091G0D52.
PhylomeDBiP46663.
TreeFamiTF330024.

Family and domain databases

InterProiView protein in InterPro
IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF
60 70 80 90 100
GLLGNLFVLL VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ
110 120 130 140 150
FNWPFGALLC RVINGVIKAN LFISIFLVVA ISQDRYRVLV HPMASRRQQR
160 170 180 190 200
RRQARVTCVL IWVVGGLLSI PTFLLRSIQA VPDLNITACI LLLPHEAWHF
210 220 230 240 250
ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC GGRKDSKTTA
260 270 280 290 300
LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
310 320 330 340 350
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF

WRN
Length:353
Mass (Da):40,495
Last modified:January 10, 2006 - v3
Checksum:iB62B0690A7593077
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146R → G (PubMed:8063797).Curated1
Sequence conflicti146R → G (PubMed:8651911).Curated1
Sequence conflicti146R → G (PubMed:8660997).Curated1
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8063797).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8651911).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8660997).Curated4
Sequence conflicti246S → R (PubMed:8651911).Curated1
Sequence conflicti259F → S in AAC50594 (PubMed:8651911).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014359250A → V. Corresponds to variant dbSNP:rs2229459Ensembl.1
Natural variantiVAR_049376317R → Q. Corresponds to variant dbSNP:rs8004609Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
AK291970 mRNA. Translation: BAF84659.1.
CH471061 Genomic DNA. Translation: EAW81632.1.
BC034705 mRNA. Translation: AAH34705.1.
CCDSiCCDS9943.1.
PIRiA53858.
RefSeqiNP_000701.2. NM_000710.3.
UniGeneiHs.525572.

Genome annotation databases

EnsembliENST00000216629; ENSP00000216629; ENSG00000100739.
ENST00000611804; ENSP00000479276; ENSG00000100739.
GeneIDi623.
KEGGihsa:623.
UCSCiuc001yfh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBKRB1_HUMAN
AccessioniPrimary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: September 27, 2017
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families