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Reviewed, UniProtKB/Swiss-Prot P46663 (BKRB1_HUMAN)

Last modified November 24, 2009. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    B1 bradykinin receptor
Alternative name(s):
    BK-1 receptor
      Short name=B1R
Gene names
Name: BDKRB1
Synonyms: BRADYB1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353B1 bradykinin receptor
PRO_0000069181

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 64241 Potential
Topological domain65 – 739Cytoplasmic Potential
Transmembrane74 – 98252 Potential
Topological domain99 – 11113Extracellular Potential
Transmembrane112 – 133223 Potential
Topological domain134 – 15522Cytoplasmic Potential
Transmembrane156 – 178234 Potential
Topological domain179 – 19921Extracellular Potential
Transmembrane200 – 226275 Potential
Topological domain227 – 24721Cytoplasmic Potential
Transmembrane248 – 272256 Potential
Topological domain273 – 29119Extracellular Potential
Transmembrane292 – 314237 Potential
Topological domain315 – 35339Cytoplasmic Potential

Amino acid modifications

Modified residue3391Phosphoserine
Lipidation3301S-palmitoyl cysteine Potential
Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 189 By similarity

Natural variations

Natural variant2501A → V: dbSNP rs2229459.
VAR_014359
Natural variant3171R → Q: dbSNP rs8004609.
VAR_049376

Experimental info

Sequence conflict1461R → G Ref.1
Sequence conflict1461R → G Ref.2
Sequence conflict1461R → G Ref.3
Sequence conflict240 – 2434CGGR → VRGP Ref.1
Sequence conflict240 – 2434CGGR → VRGP Ref.2
Sequence conflict240 – 2434CGGR → VRGP Ref.3
Sequence conflict2461S → R Ref.2
Sequence conflict2591F → S in AAC50594. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P46663-1 [UniParc].

Last modified January 10, 2006. Version 3.
Checksum: B62B0690A7593077

FASTA35340,495
        10         20         30         40         50         60 
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 

        70         80         90        100        110        120 
VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 

       130        140        150        160        170        180 
LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 

       190        200        210        220        230        240 
VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 

       250        260        270        280        290        300 
GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 

       310        320        330        340        350 
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning of a human B1 bradykinin receptor."
Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F.
J. Biol. Chem. 269:21583-21586(1994) [PubMed: 8063797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions."
Yang X., Polgar P.
Biochem. Biophys. Res. Commun. 222:718-725(1996) [PubMed: 8651911] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)."
Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.
Genomics 33:374-381(1996) [PubMed: 8660997] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular characterisation of cloned bradykinin B1 receptors from rat and human."
Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P.
Eur. J. Pharmacol. 374:423-433(1999) [PubMed: 10422787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[5]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Isolation of complete coding sequence for bradykinin receptor B1 (BDKRB1)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339, MASS SPECTROMETRY.
+Additional computationally mapped references.

Web resources

Wikipedia

Bradykinin receptor entry

Cross-references

Sequence databases

U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
BC034705 mRNA. Translation: AAH34705.1.
IPIIPI00296538.
PIRA53858.
RefSeqNP_000701.2.
UniGeneHs.525572

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP46663.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP46663.

Genome annotation databases

EnsemblENST00000216629; ENSP00000216629; ENSG00000100739; Homo sapiens. [Genome view]
GeneID623.
KEGGhsa:623.
NMPDRfig|9606.3.peg.10127.
UCSCuc001yfh.1. human.

Organism-specific databases

CTD623.
GeneCardsGC14P095792.
H-InvDBHIX0026637.
HGNCHGNC:1029. BDKRB1.
HPAHPA002935.
MIM600337. gene.
PharmGKBPA79.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP46663.
HOVERGENP46663.
OMALPFWAEN
OrthoDBEOG9K6JPP

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

ArrayExpressP46663.
BgeeP46663.
CleanExHS_BDKRB1.
GenevestigatorP46663.
GermOnlineENSG00000100739. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001186. BK_rcpt_B1.
IPR000496. Brdyknn_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio2518.
SOURCESearch...

Entry information

Entry nameBKRB1_HUMAN
AccessionPrimary (citable) accession number: P46663
Secondary accession number(s): Q546S7, Q8N0Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: November 24, 2009
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents