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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  • bradykinin receptor activity Source: ProtInc
  • peptide binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100739-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP46663.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
Synonyms:BRADYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1029. BDKRB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 64Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 98Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 199ExtracellularSequence analysisAdd BLAST21
Transmembranei200 – 226Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini227 – 247CytoplasmicSequence analysisAdd BLAST21
Transmembranei248 – 272Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini273 – 291ExtracellularSequence analysisAdd BLAST19
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 353CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi623.
OpenTargetsiENSG00000100739.
PharmGKBiPA79.

Chemistry databases

ChEMBLiCHEMBL4308.
GuidetoPHARMACOLOGYi41.

Polymorphism and mutation databases

BioMutaiBDKRB1.
DMDMi85681914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691811 – 353B1 bradykinin receptorAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 189PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Lipidationi330S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP46663.
PRIDEiP46663.

PTM databases

iPTMnetiP46663.
PhosphoSitePlusiP46663.

Expressioni

Gene expression databases

BgeeiENSG00000100739.
CleanExiHS_BDKRB1.
ExpressionAtlasiP46663. baseline and differential.
GenevisibleiP46663. HS.

Organism-specific databases

HPAiHPA002935.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623218,EBI-6623250

Protein-protein interaction databases

IntActiP46663. 1 interactor.
STRINGi9606.ENSP00000216629.

Chemistry databases

BindingDBiP46663.

Structurei

3D structure databases

ProteinModelPortaliP46663.
SMRiP46663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP46663.
KOiK03915.
OMAiFNCHILA.
OrthoDBiEOG091G0D52.
PhylomeDBiP46663.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF
60 70 80 90 100
GLLGNLFVLL VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ
110 120 130 140 150
FNWPFGALLC RVINGVIKAN LFISIFLVVA ISQDRYRVLV HPMASRRQQR
160 170 180 190 200
RRQARVTCVL IWVVGGLLSI PTFLLRSIQA VPDLNITACI LLLPHEAWHF
210 220 230 240 250
ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC GGRKDSKTTA
260 270 280 290 300
LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
310 320 330 340 350
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF

WRN
Length:353
Mass (Da):40,495
Last modified:January 10, 2006 - v3
Checksum:iB62B0690A7593077
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146R → G (PubMed:8063797).Curated1
Sequence conflicti146R → G (PubMed:8651911).Curated1
Sequence conflicti146R → G (PubMed:8660997).Curated1
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8063797).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8651911).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8660997).Curated4
Sequence conflicti246S → R (PubMed:8651911).Curated1
Sequence conflicti259F → S in AAC50594 (PubMed:8651911).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014359250A → V.Corresponds to variant rs2229459dbSNPEnsembl.1
Natural variantiVAR_049376317R → Q.Corresponds to variant rs8004609dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
AK291970 mRNA. Translation: BAF84659.1.
CH471061 Genomic DNA. Translation: EAW81632.1.
BC034705 mRNA. Translation: AAH34705.1.
CCDSiCCDS9943.1.
PIRiA53858.
RefSeqiNP_000701.2. NM_000710.3.
UniGeneiHs.525572.

Genome annotation databases

EnsembliENST00000216629; ENSP00000216629; ENSG00000100739.
ENST00000611804; ENSP00000479276; ENSG00000100739.
GeneIDi623.
KEGGihsa:623.
UCSCiuc001yfh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bradykinin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
AK291970 mRNA. Translation: BAF84659.1.
CH471061 Genomic DNA. Translation: EAW81632.1.
BC034705 mRNA. Translation: AAH34705.1.
CCDSiCCDS9943.1.
PIRiA53858.
RefSeqiNP_000701.2. NM_000710.3.
UniGeneiHs.525572.

3D structure databases

ProteinModelPortaliP46663.
SMRiP46663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46663. 1 interactor.
STRINGi9606.ENSP00000216629.

Chemistry databases

BindingDBiP46663.
ChEMBLiCHEMBL4308.
GuidetoPHARMACOLOGYi41.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP46663.
PhosphoSitePlusiP46663.

Polymorphism and mutation databases

BioMutaiBDKRB1.
DMDMi85681914.

Proteomic databases

PaxDbiP46663.
PRIDEiP46663.

Protocols and materials databases

DNASUi623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216629; ENSP00000216629; ENSG00000100739.
ENST00000611804; ENSP00000479276; ENSG00000100739.
GeneIDi623.
KEGGihsa:623.
UCSCiuc001yfh.4. human.

Organism-specific databases

CTDi623.
DisGeNETi623.
GeneCardsiBDKRB1.
HGNCiHGNC:1029. BDKRB1.
HPAiHPA002935.
MIMi600337. gene.
neXtProtiNX_P46663.
OpenTargetsiENSG00000100739.
PharmGKBiPA79.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP46663.
KOiK03915.
OMAiFNCHILA.
OrthoDBiEOG091G0D52.
PhylomeDBiP46663.
TreeFamiTF330024.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100739-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP46663.

Miscellaneous databases

GeneWikiiBradykinin_receptor_B1.
GenomeRNAii623.
PROiP46663.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100739.
CleanExiHS_BDKRB1.
ExpressionAtlasiP46663. baseline and differential.
GenevisibleiP46663. HS.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB1_HUMAN
AccessioniPrimary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.