Reviewed, UniProtKB/Swiss-Prot P46663 (BKRB1_HUMAN)

Names and origin

Protein names

Recommended name:
    B1 bradykinin receptor
Alternative name(s):
    BK-1 receptor
      Short name=B1R

Gene names

Name:	BDKRB1
Synonyms:	BRADYB1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	elevation of cytosolic calcium ion concentration Ref.1 Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum Traceable author statement. Source: ProtInc integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	bradykinin receptor activity Ref.4 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	B1 bradykinin receptor		PRO_0000069181
Regions
	Topological domain	1 – 40	40	Extracellular Potential
	Transmembrane	41 – 64	24	1 Potential
	Topological domain	65 – 73	9	Cytoplasmic Potential
	Transmembrane	74 – 98	25	2 Potential
	Topological domain	99 – 111	13	Extracellular Potential
	Transmembrane	112 – 133	22	3 Potential
	Topological domain	134 – 155	22	Cytoplasmic Potential
	Transmembrane	156 – 178	23	4 Potential
	Topological domain	179 – 199	21	Extracellular Potential
	Transmembrane	200 – 226	27	5 Potential
	Topological domain	227 – 247	21	Cytoplasmic Potential
	Transmembrane	248 – 272	25	6 Potential
	Topological domain	273 – 291	19	Extracellular Potential
	Transmembrane	292 – 314	23	7 Potential
	Topological domain	315 – 353	39	Cytoplasmic Potential
Amino acid modifications
	Modified residue	339	1	Phosphoserine
	Lipidation	330	1	S-palmitoyl cysteine Potential
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	185	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 189		By similarity
Natural variations
	Natural variant	250	1	A → V: dbSNP rs2229459.		VAR_014359
	Natural variant	317	1	R → Q: dbSNP rs8004609.		VAR_049376
Experimental info
	Sequence conflict	146	1	R → G Ref.1
	Sequence conflict	146	1	R → G Ref.2
	Sequence conflict	146	1	R → G Ref.3
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.1
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.2
	Sequence conflict	240 – 243	4	CGGR → VRGP Ref.3
	Sequence conflict	246	1	S → R Ref.2
	Sequence conflict	259	1	F → S in AAC50594. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P46663-1 [UniParc]. Last modified January 10, 2006. Version 3. Checksum: B62B0690A7593077	FASTA	353	40,495
	10 20 30 40 50 60 MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 70 80 90 100 110 120 VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 130 140 150 160 170 180 LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 190 200 210 220 230 240 VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 250 260 270 280 290 300 GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 310 320 330 340 350 AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a human B1 bradykinin receptor." Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F. J. Biol. Chem. 269:21583-21586(1994) [PubMed: 8063797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions." Yang X., Polgar P. Biochem. Biophys. Res. Commun. 222:718-725(1996) [PubMed: 8651911] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)." Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F. Genomics 33:374-381(1996) [PubMed: 8660997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Molecular characterisation of cloned bradykinin B1 receptors from rat and human." Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P. Eur. J. Pharmacol. 374:423-433(1999) [PubMed: 10422787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[5]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Isolation of complete coding sequence for bradykinin receptor B1 (BDKRB1)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Bradykinin receptor entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	U12512 mRNA. Translation: AAA21346.1. U22346 Genomic DNA. Translation: AAC50594.1. U48231 Genomic DNA. Translation: AAB60693.1. AJ238044 mRNA. Translation: CAB45650.1. AB065896 Genomic DNA. Translation: BAC06112.1. AY275464 Genomic DNA. Translation: AAP32296.1. BC034705 mRNA. Translation: AAH34705.1.
IPI	IPI00296538.
PIR	A53858.
RefSeq	NP_000701.2.
UniGene	Hs.525572
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P46663.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P46663.
Genome annotation databases
Ensembl	ENST00000216629; ENSP00000216629; ENSG00000100739; Homo sapiens. [Genome view]
GeneID	623.
KEGG	hsa:623.
NMPDR	fig|9606.3.peg.10127.
UCSC	uc001yfh.1. human.
Organism-specific databases
CTD	623.
GeneCards	GC14P095792.
H-InvDB	HIX0026637.
HGNC	HGNC:1029. BDKRB1.
HPA	HPA002935.
MIM	600337. gene.
PharmGKB	PA79.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P46663.
HOVERGEN	P46663.
OMA	LPFWAEN
OrthoDB	EOG9K6JPP
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P46663.
Bgee	P46663.
CleanEx	HS_BDKRB1.
Genevestigator	P46663.
GermOnline	ENSG00000100739. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001186. BK_rcpt_B1. IPR000496. Brdyknn_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00425. BRADYKININR. PR00993. BRADYKINNB1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2518.
SOURCE	Search...

Entry information

Entry name

BKRB1_HUMAN

Accession

Primary (citable) accession number: P46663
Secondary accession number(s): Q546S7, Q8N0Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 10, 2006
Last modified:	November 24, 2009
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.