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P46663 (BKRB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B1 bradykinin receptor

Short name=B1R
Short name=BK-1 receptor
Gene names
Name:BDKRB1
Synonyms:BRADYB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Traceable author statement Ref.1. Source: ProtInc

positive regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: InterPro

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Traceable author statement PubMed 9930991. Source: ProtInc

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

neuron projection

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionbradykinin receptor activity

Traceable author statement Ref.4. Source: ProtInc

peptide binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KNG1P010422EBI-6623218,EBI-6623250

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353B1 bradykinin receptor
PRO_0000069181

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 6424Helical; Name=1; Potential
Topological domain65 – 739Cytoplasmic Potential
Transmembrane74 – 9825Helical; Name=2; Potential
Topological domain99 – 11113Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15522Cytoplasmic Potential
Transmembrane156 – 17823Helical; Name=4; Potential
Topological domain179 – 19921Extracellular Potential
Transmembrane200 – 22627Helical; Name=5; Potential
Topological domain227 – 24721Cytoplasmic Potential
Transmembrane248 – 27225Helical; Name=6; Potential
Topological domain273 – 29119Extracellular Potential
Transmembrane292 – 31423Helical; Name=7; Potential
Topological domain315 – 35339Cytoplasmic Potential

Amino acid modifications

Lipidation3301S-palmitoyl cysteine Potential
Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 189 By similarity

Natural variations

Natural variant2501A → V.
Corresponds to variant rs2229459 [ dbSNP | Ensembl ].
VAR_014359
Natural variant3171R → Q.
Corresponds to variant rs8004609 [ dbSNP | Ensembl ].
VAR_049376

Experimental info

Sequence conflict1461R → G Ref.1
Sequence conflict1461R → G Ref.2
Sequence conflict1461R → G Ref.3
Sequence conflict240 – 2434CGGR → VRGP Ref.1
Sequence conflict240 – 2434CGGR → VRGP Ref.2
Sequence conflict240 – 2434CGGR → VRGP Ref.3
Sequence conflict2461S → R Ref.2
Sequence conflict2591F → S in AAC50594. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P46663 [UniParc].

Last modified January 10, 2006. Version 3.
Checksum: B62B0690A7593077

FASTA35340,495
        10         20         30         40         50         60 
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 

        70         80         90        100        110        120 
VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 

       130        140        150        160        170        180 
LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 

       190        200        210        220        230        240 
VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 

       250        260        270        280        290        300 
GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 

       310        320        330        340        350 
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning of a human B1 bradykinin receptor."
Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F.
J. Biol. Chem. 269:21583-21586(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions."
Yang X., Polgar P.
Biochem. Biophys. Res. Commun. 222:718-725(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)."
Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.
Genomics 33:374-381(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular characterisation of cloned bradykinin B1 receptors from rat and human."
Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P.
Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[5]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Isolation of complete coding sequence for bradykinin receptor B1 (BDKRB1)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

Web resources

Wikipedia

Bradykinin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12512 mRNA. Translation: AAA21346.1.
U22346 Genomic DNA. Translation: AAC50594.1.
U48231 Genomic DNA. Translation: AAB60693.1.
AJ238044 mRNA. Translation: CAB45650.1.
AB065896 Genomic DNA. Translation: BAC06112.1.
AY275464 Genomic DNA. Translation: AAP32296.1.
AK291970 mRNA. Translation: BAF84659.1.
CH471061 Genomic DNA. Translation: EAW81632.1.
BC034705 mRNA. Translation: AAH34705.1.
CCDSCCDS9943.1.
PIRA53858.
RefSeqNP_000701.2. NM_000710.3.
UniGeneHs.525572.

3D structure databases

ProteinModelPortalP46663.
SMRP46663. Positions 1-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107092. 1 interaction.
IntActP46663. 1 interaction.
STRING9606.ENSP00000216629.

Chemistry

BindingDBP46663.
ChEMBLCHEMBL4308.
GuidetoPHARMACOLOGY41.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM85681914.

Proteomic databases

PaxDbP46663.
PRIDEP46663.

Protocols and materials databases

DNASU623.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216629; ENSP00000216629; ENSG00000100739.
GeneID623.
KEGGhsa:623.
UCSCuc001yfh.3. human.

Organism-specific databases

CTD623.
GeneCardsGC14P096722.
HGNCHGNC:1029. BDKRB1.
HPAHPA002935.
MIM600337. gene.
neXtProtNX_P46663.
PharmGKBPA79.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327312.
HOGENOMHOG000010314.
HOVERGENHBG103183.
InParanoidP46663.
KOK03915.
OMAPYHFFAF.
OrthoDBEOG7K9K36.
PhylomeDBP46663.
TreeFamTF330024.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP46663.
CleanExHS_BDKRB1.
GenevestigatorP46663.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBradykinin_receptor_B1.
GenomeRNAi623.
NextBio2518.
PROP46663.
SOURCESearch...

Entry information

Entry nameBKRB1_HUMAN
AccessionPrimary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries