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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  • bradykinin receptor activity Source: ProtInc
  • peptide binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiP46663

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
Synonyms:BRADYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100739.10
HGNCiHGNC:1029 BDKRB1
MIMi600337 gene
neXtProtiNX_P46663

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 64Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 98Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 199ExtracellularSequence analysisAdd BLAST21
Transmembranei200 – 226Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini227 – 247CytoplasmicSequence analysisAdd BLAST21
Transmembranei248 – 272Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini273 – 291ExtracellularSequence analysisAdd BLAST19
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 353CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi623
OpenTargetsiENSG00000100739
PharmGKBiPA79

Chemistry databases

ChEMBLiCHEMBL4308
GuidetoPHARMACOLOGYi41

Polymorphism and mutation databases

BioMutaiBDKRB1
DMDMi85681914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691811 – 353B1 bradykinin receptorAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 189PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi330S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP46663
PeptideAtlasiP46663
PRIDEiP46663
ProteomicsDBi55746

PTM databases

iPTMnetiP46663
PhosphoSitePlusiP46663

Expressioni

Gene expression databases

BgeeiENSG00000100739
CleanExiHS_BDKRB1
ExpressionAtlasiP46663 baseline and differential
GenevisibleiP46663 HS

Organism-specific databases

HPAiHPA002935

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623218,EBI-6623250

Protein-protein interaction databases

IntActiP46663, 1 interactor
STRINGi9606.ENSP00000216629

Chemistry databases

BindingDBiP46663

Structurei

3D structure databases

ProteinModelPortaliP46663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000010314
HOVERGENiHBG103183
InParanoidiP46663
KOiK03915
OMAiFNCHILA
OrthoDBiEOG091G0D52
PhylomeDBiP46663
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR001186 Brdyknn_1_rcpt
IPR000496 Brdyknn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00425 BRADYKININR
PR00993 BRADYKINNB1R
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF
60 70 80 90 100
GLLGNLFVLL VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ
110 120 130 140 150
FNWPFGALLC RVINGVIKAN LFISIFLVVA ISQDRYRVLV HPMASRRQQR
160 170 180 190 200
RRQARVTCVL IWVVGGLLSI PTFLLRSIQA VPDLNITACI LLLPHEAWHF
210 220 230 240 250
ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC GGRKDSKTTA
260 270 280 290 300
LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
310 320 330 340 350
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF

WRN
Length:353
Mass (Da):40,495
Last modified:January 10, 2006 - v3
Checksum:iB62B0690A7593077
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146R → G (PubMed:8063797).Curated1
Sequence conflicti146R → G (PubMed:8651911).Curated1
Sequence conflicti146R → G (PubMed:8660997).Curated1
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8063797).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8651911).Curated4
Sequence conflicti240 – 243CGGR → VRGP (PubMed:8660997).Curated4
Sequence conflicti246S → R (PubMed:8651911).Curated1
Sequence conflicti259F → S in AAC50594 (PubMed:8651911).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014359250A → V. Corresponds to variant dbSNP:rs2229459Ensembl.1
Natural variantiVAR_049376317R → Q. Corresponds to variant dbSNP:rs8004609Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12512 mRNA Translation: AAA21346.1
U22346 Genomic DNA Translation: AAC50594.1
U48231 Genomic DNA Translation: AAB60693.1
AJ238044 mRNA Translation: CAB45650.1
AB065896 Genomic DNA Translation: BAC06112.1
AY275464 Genomic DNA Translation: AAP32296.1
AK291970 mRNA Translation: BAF84659.1
CH471061 Genomic DNA Translation: EAW81632.1
BC034705 mRNA Translation: AAH34705.1
CCDSiCCDS9943.1
PIRiA53858
RefSeqiNP_000701.2, NM_000710.3
UniGeneiHs.525572

Genome annotation databases

EnsembliENST00000216629; ENSP00000216629; ENSG00000100739
ENST00000611804; ENSP00000479276; ENSG00000100739
GeneIDi623
KEGGihsa:623
UCSCiuc001yfh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBKRB1_HUMAN
AccessioniPrimary (citable) accession number: P46663
Secondary accession number(s): A8K7F5, Q546S7, Q8N0Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2006
Last modified: June 20, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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