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Protein

Alpha-internexin

Gene

Ina

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cellular response to leukemia inhibitory factor Source: MGI
  • intermediate filament cytoskeleton organization Source: MGI
  • nervous system development Source: UniProtKB-KW
  • neurofilament cytoskeleton organization Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-internexin
Short name:
Alpha-Inx
Alternative name(s):
66 kDa neurofilament protein
Short name:
NF-66
Short name:
Neurofilament-66
Gene namesi
Name:Ina
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:96568 Ina

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637841 – 501Alpha-internexinAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei290N6-acetyllysineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP46660
PaxDbiP46660
PeptideAtlasiP46660
PRIDEiP46660

2D gel databases

UCD-2DPAGEP46660

PTM databases

iPTMnetiP46660
PhosphoSitePlusiP46660
SwissPalmiP46660

Expressioni

Gene expression databases

BgeeiENSMUSG00000034336
GenevisibleiP46660 MM

Interactioni

Protein-protein interaction databases

BioGridi230487, 15 interactors
IntActiP46660, 17 interactors
MINTiP46660
STRINGi10090.ENSMUSP00000041347

Structurei

3D structure databases

ProteinModelPortaliP46660
SMRiP46660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 407IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 87HeadAdd BLAST87
Regioni88 – 129Coil 1AAdd BLAST42
Regioni130 – 142Linker 1Add BLAST13
Regioni143 – 238Coil 1BAdd BLAST96
Regioni239 – 262Linker 2Add BLAST24
Regioni263 – 408Coil 2Add BLAST146
Regioni409 – 501TailAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi449 – 456Poly-Glu8

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGME Eukaryota
ENOG410XPTM LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiP46660
KOiK07608
OMAiNDYRHRY
OrthoDBiEOG091G12MK
TreeFamiTF330122

Family and domain databases

InterProiView protein in InterPro
IPR027703 Alpha-Inx
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF132 PTHR23239:SF132, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGSEHYLC SASSYRKVFG DSSRLSARLS GPGGSGSFRS QSLSRSNVAS
60 70 80 90 100
TAACSSASSL GLGLAYRRLP ASDGLDLSQA AARTNEYKII RTNEKEQLQG
110 120 130 140 150
LNDRFAVFIE KVHQLETQNR ALEAELAALR QRHAEPSRVG ELFQRELREL
160 170 180 190 200
RAQLEEASSA RAQALLERDG LAEEVQRLRA RCEEESRGRE GAERALKAQQ
210 220 230 240 250
RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA TLQASSQAAA
260 270 280 290 300
EVDVAVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR
310 320 330 340 350
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE
360 370 380 390 400
VAGYQDSIGQ LESDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL
410 420 430 440 450
EGEETRFSTG GLSISGLNPL PNPSYLLPPR ILSSTASKVS SAGLSLKKEE
460 470 480 490 500
EEEEEEASKE VSKKTSKVGE GFEETLGEAV ISTKKTGKSA TEESTSSSQK

M
Length:501
Mass (Da):55,383
Last modified:January 22, 2014 - v3
Checksum:iB3DEF649DEB29C3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28R → P in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti34G → A in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti141E → Q in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti147L → R in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti163Q → E in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti297Q → L in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti301S → T in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti318 – 319QL → HV in AAB37740 (PubMed:8734438).Curated2
Sequence conflicti347H → D in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti383L → F in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti388A → G in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti403E → N in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti442A → T in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti442A → T in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti443G → R in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti450E → D in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti450E → D in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti455E → EEEE in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti456E → D in AAA62617 (PubMed:7959004).Curated1
Sequence conflicti456E → D in AAB37740 (PubMed:8734438).Curated1
Sequence conflicti489S → L in AAB37740 (PubMed:8734438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27220 Genomic DNA Translation: AAA62617.1
L36390 mRNA Translation: AAB37740.1
BC018383 mRNA Translation: AAH18383.1
CCDSiCCDS38013.1
PIRiI53868
RefSeqiNP_666212.3, NM_146100.4
UniGeneiMm.276251

Genome annotation databases

EnsembliENSMUST00000037636; ENSMUSP00000041347; ENSMUSG00000034336
GeneIDi226180
KEGGimmu:226180
UCSCiuc008huk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAINX_MOUSE
AccessioniPrimary (citable) accession number: P46660
Secondary accession number(s): Q61958, Q8VCW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 22, 2014
Last modified: May 23, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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