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P46656 (ADX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adrenodoxin, mitochondrial
Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1
Gene names
Name:Fdx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage By similarity.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Subunit structure

Interacts with CYP11A1 By similarity.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the adrenodoxin/putidaredoxin family.

Contains 1 2Fe-2S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6464Mitochondrion By similarity
Chain65 – 188124Adrenodoxin, mitochondrial
PRO_0000000989

Regions

Domain69 – 1751072Fe-2S ferredoxin-type

Sites

Metal binding1101Iron-sulfur (2Fe-2S) By similarity
Metal binding1161Iron-sulfur (2Fe-2S) By similarity
Metal binding1191Iron-sulfur (2Fe-2S) By similarity
Metal binding1561Iron-sulfur (2Fe-2S) By similarity

Amino acid modifications

Modified residue701N6-acetyllysine; alternate Ref.4
Modified residue701N6-succinyllysine; alternate Ref.3
Modified residue1621N6-succinyllysine Ref.3

Sequences

Sequence LengthMass (Da)Tools
P46656 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1118DE79BC8BDF48

FASTA18820,123
        10         20         30         40         50         60 
MAAAPGARLL RAACASVPFR GLDRCRLLVC GTGAGTAISP WTPSPRLHAE AGPGRPLSVS 

        70         80         90        100        110        120 
ARARSSSEDK ITVHFKNRDG ETLTTKGKIG DSLLDVVIEN NLDIDGFGAC EGTLACSTCH 

       130        140        150        160        170        180 
LIFEDHIYEK LDAITDEEND MLDLAFGLTD RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ 


SVDMSKNS 

« Hide

References

« Hide 'large scale' references
[1]"A full-length cDNA encoding mouse adrenodoxin."
Stromstedt M., Waterman M.R.
Biochim. Biophys. Acta 1261:126-128(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.
[2]"Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin."
Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T.
Biochim. Biophys. Acta 1263:173-175(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Kidney.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29123 mRNA. Translation: AAA74303.1.
D43689 mRNA. Translation: BAA07786.1.
D43690 mRNA. Translation: BAA07787.1.
PIRS53524.
RefSeqNP_032022.1. NM_007996.1.
UniGeneMm.1061.
Mm.440190.

3D structure databases

ProteinModelPortalP46656.
SMRP46656. Positions 65-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1861080.

PTM databases

PhosphoSiteP46656.

Proteomic databases

PaxDbP46656.
PRIDEP46656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034552; ENSMUSP00000034552; ENSMUSG00000032051.
GeneID14148.
KEGGmmu:14148.
UCSCuc009plo.1. mouse.

Organism-specific databases

CTD2230.
MGIMGI:103224. Fdx1.

Phylogenomic databases

eggNOGCOG0633.
HOGENOMHOG000244518.
HOVERGENHBG000092.
InParanoidP46656.
OMADHIFEKL.
OrthoDBEOG708W1D.
PhylomeDBP46656.
TreeFamTF319845.

Gene expression databases

ArrayExpressP46656.
BgeeP46656.
CleanExMM_FDX1.
GenevestigatorP46656.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSPR00355. ADRENODOXIN.
SUPFAMSSF54292. SSF54292. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285254.
PROP46656.
SOURCESearch...

Entry information

Entry nameADX_MOUSE
AccessionPrimary (citable) accession number: P46656
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot