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P46656

- ADX_MOUSE

UniProt

P46656 - ADX_MOUSE

Protein

Adrenodoxin, mitochondrial

Gene

Fdx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage By similarity.By similarity

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi110 – 1101Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi119 – 1191Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi156 – 1561Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. electron carrier activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cholesterol metabolic process Source: UniProtKB
    2. hormone biosynthetic process Source: UniProtKB
    3. oxidation-reduction process Source: UniProtKB-KW
    4. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Biological processi

    Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196619. Electron transport from NADPH to Ferredoxin.
    REACT_199053. Mitochondrial iron-sulfur cluster biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adrenodoxin, mitochondrial
    Alternative name(s):
    Adrenal ferredoxin
    Ferredoxin-1
    Gene namesi
    Name:Fdx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:103224. Fdx1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6464MitochondrionBy similarityAdd
    BLAST
    Chaini65 – 188124Adrenodoxin, mitochondrialPRO_0000000989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-acetyllysine; alternate1 Publication
    Modified residuei70 – 701N6-succinyllysine; alternate1 Publication
    Modified residuei162 – 1621N6-succinyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP46656.
    PaxDbiP46656.
    PRIDEiP46656.

    PTM databases

    PhosphoSiteiP46656.

    Expressioni

    Gene expression databases

    ArrayExpressiP46656.
    BgeeiP46656.
    CleanExiMM_FDX1.
    GenevestigatoriP46656.

    Interactioni

    Subunit structurei

    Interacts with CYP11A1.By similarity

    Protein-protein interaction databases

    MINTiMINT-1861080.

    Structurei

    3D structure databases

    ProteinModelPortaliP46656.
    SMRiP46656. Positions 65-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 1751072Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adrenodoxin/putidaredoxin family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0633.
    HOGENOMiHOG000244518.
    HOVERGENiHBG000092.
    InParanoidiP46656.
    OMAiARQSVDM.
    OrthoDBiEOG708W1D.
    PhylomeDBiP46656.
    TreeFamiTF319845.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR001055. Adrenodoxin.
    IPR018298. Adrenodoxin_Fe-S_BS.
    IPR012675. Beta-grasp_dom.
    [Graphical view]
    PfamiPF00111. Fer2. 1 hit.
    [Graphical view]
    PRINTSiPR00355. ADRENODOXIN.
    SUPFAMiSSF54292. SSF54292. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS00814. ADX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46656-1 [UniParc]FASTAAdd to Basket

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    MAAAPGARLL RAACASVPFR GLDRCRLLVC GTGAGTAISP WTPSPRLHAE    50
    AGPGRPLSVS ARARSSSEDK ITVHFKNRDG ETLTTKGKIG DSLLDVVIEN 100
    NLDIDGFGAC EGTLACSTCH LIFEDHIYEK LDAITDEEND MLDLAFGLTD 150
    RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS 188
    Length:188
    Mass (Da):20,123
    Last modified:November 1, 1995 - v1
    Checksum:i1118DE79BC8BDF48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29123 mRNA. Translation: AAA74303.1.
    D43689 mRNA. Translation: BAA07786.1.
    D43690 mRNA. Translation: BAA07787.1.
    CCDSiCCDS23178.1.
    PIRiS53524.
    RefSeqiNP_032022.1. NM_007996.1.
    UniGeneiMm.1061.
    Mm.440190.

    Genome annotation databases

    EnsembliENSMUST00000034552; ENSMUSP00000034552; ENSMUSG00000032051.
    GeneIDi14148.
    KEGGimmu:14148.
    UCSCiuc009plo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29123 mRNA. Translation: AAA74303.1 .
    D43689 mRNA. Translation: BAA07786.1 .
    D43690 mRNA. Translation: BAA07787.1 .
    CCDSi CCDS23178.1.
    PIRi S53524.
    RefSeqi NP_032022.1. NM_007996.1.
    UniGenei Mm.1061.
    Mm.440190.

    3D structure databases

    ProteinModelPortali P46656.
    SMRi P46656. Positions 65-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1861080.

    PTM databases

    PhosphoSitei P46656.

    Proteomic databases

    MaxQBi P46656.
    PaxDbi P46656.
    PRIDEi P46656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034552 ; ENSMUSP00000034552 ; ENSMUSG00000032051 .
    GeneIDi 14148.
    KEGGi mmu:14148.
    UCSCi uc009plo.1. mouse.

    Organism-specific databases

    CTDi 2230.
    MGIi MGI:103224. Fdx1.

    Phylogenomic databases

    eggNOGi COG0633.
    HOGENOMi HOG000244518.
    HOVERGENi HBG000092.
    InParanoidi P46656.
    OMAi ARQSVDM.
    OrthoDBi EOG708W1D.
    PhylomeDBi P46656.
    TreeFami TF319845.

    Enzyme and pathway databases

    Reactomei REACT_196619. Electron transport from NADPH to Ferredoxin.
    REACT_199053. Mitochondrial iron-sulfur cluster biogenesis.

    Miscellaneous databases

    NextBioi 285254.
    PROi P46656.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46656.
    Bgeei P46656.
    CleanExi MM_FDX1.
    Genevestigatori P46656.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR001055. Adrenodoxin.
    IPR018298. Adrenodoxin_Fe-S_BS.
    IPR012675. Beta-grasp_dom.
    [Graphical view ]
    Pfami PF00111. Fer2. 1 hit.
    [Graphical view ]
    PRINTSi PR00355. ADRENODOXIN.
    SUPFAMi SSF54292. SSF54292. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS00814. ADX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal gland.
    2. "Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin."
      Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T.
      Biochim. Biophys. Acta 1263:173-175(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Kidney.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiADX_MOUSE
    AccessioniPrimary (citable) accession number: P46656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3