Reviewed,
UniProtKB/Swiss-Prot P46656 (ADX_MOUSE)
Last modified
November 25, 2008.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adrenodoxin, mitochondrial Alternative name(s): Adrenal ferredoxin Ferredoxin-1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Adrenodoxin transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450. |
| Cofactor | Binds 1 2Fe-2S cluster By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | 2Fe-2S Iron Iron-sulfur Metal-binding |
Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 64 | 64 | Mitochondrion By similarity | ||||||
| Chain | 65 – 188 | 124 | Adrenodoxin, mitochondrial | PRO_0000000989 | |||||
Regions | |||||||||
| Domain | 69 – 175 | 107 | 2Fe-2S ferredoxin-type | ||||||
Sites | |||||||||
| Metal binding | 110 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 116 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 119 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 156 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
Sequences
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References
| [1] | "A full-length cDNA encoding mouse adrenodoxin." Stromstedt M., Waterman M.R. Biochim. Biophys. Acta 1261:126-128(1995) [PubMed: 7893748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal gland. |
| [2] | "Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin." Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T. Biochim. Biophys. Acta 1263:173-175(1995) [PubMed: 7640310] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L29123 mRNA. Translation: AAA74303.1. D43689 mRNA. Translation: BAA07786.1. D43690 mRNA. Translation: BAA07787.1. | |
| PIR | S53524. |
| RefSeq | NP_032022.1. |
| UniGene | Mm.1061 Mm.440190 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1L6U based on UniProtKB P00257. |
| SMR | P46656. Positions 69-172. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P46656. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000032051. Mus musculus. [Contig view] |
| GeneID | 14148. |
| KEGG | mmu:14148. |
Organism-specific databases | |
| MGI | MGI:103224. Fdx1. |
Phylogenomic databases | |
| HOGENOM | P46656. |
| HOVERGEN | P46656. |
Gene expression databases | |
| ArrayExpress | P46656. |
| CleanEx | MM_FDX1. |
| GermOnline | ENSMUSG00000032051. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001055. Adrenodoxin. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. [Graphical view] |
| Gene3D | G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. |
| Pfam | PF00111. Fer2. 1 hit. [Graphical view] |
| PRINTS | PR00355. ADRENODOXIN. |
| PROSITE | PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 285254. |
| SOURCE | Search... |
Entry information
| Entry name | ADX_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P46656 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


