P46656 (ADX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adrenodoxin, mitochondrial

Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1

Gene names

Name:

Fdx1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adrenodoxin transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450.
Cofactor	Binds 1 2Fe-2S cluster By similarity.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 64	64	Mitochondrion By similarity
	Chain	65 – 188	124	Adrenodoxin, mitochondrial		PRO_0000000989
Regions
	Domain	69 – 175	107	2Fe-2S ferredoxin-type
Sites
	Metal binding	110	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	116	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	119	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	156	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46656 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1118DE79BC8BDF48	FASTA	188	20,123
	10 20 30 40 50 60 MAAAPGARLL RAACASVPFR GLDRCRLLVC GTGAGTAISP WTPSPRLHAE AGPGRPLSVS 70 80 90 100 110 120 ARARSSSEDK ITVHFKNRDG ETLTTKGKIG DSLLDVVIEN NLDIDGFGAC EGTLACSTCH 130 140 150 160 170 180 LIFEDHIYEK LDAITDEEND MLDLAFGLTD RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS

References

[1]	"A full-length cDNA encoding mouse adrenodoxin." Stromstedt M., Waterman M.R. Biochim. Biophys. Acta 1261:126-128(1995) [PubMed: 7893748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal gland.
[2]	"Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin." Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T. Biochim. Biophys. Acta 1263:173-175(1995) [PubMed: 7640310] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L29123 mRNA. Translation: AAA74303.1. D43689 mRNA. Translation: BAA07786.1. D43690 mRNA. Translation: BAA07787.1.
IPI	IPI00135939.
PIR	S53524.
RefSeq	NP_032022.1. NM_007996.1.
UniGene	Mm.1061. Mm.440190.
3D structure databases
ProteinModelPortal	P46656.
SMR	P46656. Positions 65-172.
ModBase	Search...
Protein-protein interaction databases
STRING	P46656.
PTM databases
PhosphoSite	P46656.
Proteomic databases
PRIDE	P46656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034552; ENSMUSP00000034552; ENSMUSG00000032051.
GeneID	14148.
KEGG	mmu:14148.
Organism-specific databases
CTD	2230.
MGI	MGI:103224. Fdx1.
Phylogenomic databases
eggNOG	roNOG15890.
HOGENOM	HBG524254.
HOVERGEN	HBG000092.
InParanoid	P46656.
OMA	CQVCLTK.
OrthoDB	EOG4DNF5T.
PhylomeDB	P46656.
Gene expression databases
ArrayExpress	P46656.
Bgee	P46656.
CleanEx	MM_FDX1.
Genevestigator	P46656.
GermOnline	ENSMUSG00000032051. Mus musculus.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. Beta-grasp_ferredoxin-type. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
SUPFAM	SSF54292. Ferredoxin. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285254.
SOURCE	Search...

Entry information

Entry name

ADX_MOUSE

Accession

Primary (citable) accession number: P46656

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 19, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program