P46656 (ADX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adrenodoxin, mitochondrial

Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1

Gene names

Name:

Fdx1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage By similarity.
Cofactor	Binds 1 2Fe-2S cluster By similarity.
Subunit structure	Interacts with CYP11A1 By similarity.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Cholesterol metabolism Electron transport Lipid metabolism Steroid metabolism Steroidogenesis Sterol metabolism Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI
Molecular_function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 64	64	Mitochondrion By similarity
	Chain	65 – 188	124	Adrenodoxin, mitochondrial		PRO_0000000989
Regions
	Domain	69 – 175	107	2Fe-2S ferredoxin-type
Sites
	Metal binding	110	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	116	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	119	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	156	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46656 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1118DE79BC8BDF48	FASTA	188	20,123
	10 20 30 40 50 60 MAAAPGARLL RAACASVPFR GLDRCRLLVC GTGAGTAISP WTPSPRLHAE AGPGRPLSVS 70 80 90 100 110 120 ARARSSSEDK ITVHFKNRDG ETLTTKGKIG DSLLDVVIEN NLDIDGFGAC EGTLACSTCH 130 140 150 160 170 180 LIFEDHIYEK LDAITDEEND MLDLAFGLTD RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS

References

[1]	"A full-length cDNA encoding mouse adrenodoxin." Stromstedt M., Waterman M.R. Biochim. Biophys. Acta 1261:126-128(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal gland.
[2]	"Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin." Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T. Biochim. Biophys. Acta 1263:173-175(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L29123 mRNA. Translation: AAA74303.1. D43689 mRNA. Translation: BAA07786.1. D43690 mRNA. Translation: BAA07787.1.
IPI	IPI00135939.
PIR	S53524.
RefSeq	NP_032022.1. NM_007996.1.
UniGene	Mm.1061. Mm.440190.
3D structure databases
ProteinModelPortal	P46656.
SMR	P46656. Positions 65-172.
ModBase	Search...
PTM databases
PhosphoSite	P46656.
Proteomic databases
PaxDb	P46656.
PRIDE	P46656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034552; ENSMUSP00000034552; ENSMUSG00000032051.
GeneID	14148.
KEGG	mmu:14148.
Organism-specific databases
CTD	2230.
MGI	MGI:103224. Fdx1.
Phylogenomic databases
eggNOG	COG0633.
HOGENOM	HOG000244518.
HOVERGEN	HBG000092.
InParanoid	P46656.
OMA	GCQVCLT.
OrthoDB	EOG4DNF5T.
Gene expression databases
ArrayExpress	P46656.
Bgee	P46656.
CleanEx	MM_FDX1.
Genevestigator	P46656.
GermOnline	ENSMUSG00000032051. Mus musculus.
Family and domain databases
Gene3D	3.10.20.30. 1 hit.
InterPro	IPR001041. 2Fe-2S_ferredoxin-type. IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. Beta-grasp_dom. [Graphical view]
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
SUPFAM	SSF54292. Ferredoxin. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285254.
SOURCE	Search...

Entry information

Entry name

ADX_MOUSE

Accession

Primary (citable) accession number: P46656

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program