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P46656

- ADX_MOUSE

UniProt

P46656 - ADX_MOUSE

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Protein
Adrenodoxin, mitochondrial
Gene
Fdx1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage By similarity.

Cofactori

Binds 1 2Fe-2S cluster By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Iron-sulfur (2Fe-2S) By similarity
Metal bindingi116 – 1161Iron-sulfur (2Fe-2S) By similarity
Metal bindingi119 – 1191Iron-sulfur (2Fe-2S) By similarity
Metal bindingi156 – 1561Iron-sulfur (2Fe-2S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. electron carrier activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB
  2. hormone biosynthetic process Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB-KW
  4. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196619. Electron transport from NADPH to Ferredoxin.
REACT_199053. Mitochondrial iron-sulfur cluster biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenodoxin, mitochondrial
Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1
Gene namesi
Name:Fdx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:103224. Fdx1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6464Mitochondrion By similarity
Add
BLAST
Chaini65 – 188124Adrenodoxin, mitochondrial
PRO_0000000989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysine; alternate1 Publication
Modified residuei70 – 701N6-succinyllysine; alternate1 Publication
Modified residuei162 – 1621N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP46656.
PaxDbiP46656.
PRIDEiP46656.

PTM databases

PhosphoSiteiP46656.

Expressioni

Gene expression databases

ArrayExpressiP46656.
BgeeiP46656.
CleanExiMM_FDX1.
GenevestigatoriP46656.

Interactioni

Subunit structurei

Interacts with CYP11A1 By similarity.

Protein-protein interaction databases

MINTiMINT-1861080.

Structurei

3D structure databases

ProteinModelPortaliP46656.
SMRiP46656. Positions 65-172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 1751072Fe-2S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0633.
HOGENOMiHOG000244518.
HOVERGENiHBG000092.
InParanoidiP46656.
OMAiARQSVDM.
OrthoDBiEOG708W1D.
PhylomeDBiP46656.
TreeFamiTF319845.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSiPR00355. ADRENODOXIN.
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46656-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAPGARLL RAACASVPFR GLDRCRLLVC GTGAGTAISP WTPSPRLHAE    50
AGPGRPLSVS ARARSSSEDK ITVHFKNRDG ETLTTKGKIG DSLLDVVIEN 100
NLDIDGFGAC EGTLACSTCH LIFEDHIYEK LDAITDEEND MLDLAFGLTD 150
RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS 188
Length:188
Mass (Da):20,123
Last modified:November 1, 1995 - v1
Checksum:i1118DE79BC8BDF48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29123 mRNA. Translation: AAA74303.1.
D43689 mRNA. Translation: BAA07786.1.
D43690 mRNA. Translation: BAA07787.1.
CCDSiCCDS23178.1.
PIRiS53524.
RefSeqiNP_032022.1. NM_007996.1.
UniGeneiMm.1061.
Mm.440190.

Genome annotation databases

EnsembliENSMUST00000034552; ENSMUSP00000034552; ENSMUSG00000032051.
GeneIDi14148.
KEGGimmu:14148.
UCSCiuc009plo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29123 mRNA. Translation: AAA74303.1 .
D43689 mRNA. Translation: BAA07786.1 .
D43690 mRNA. Translation: BAA07787.1 .
CCDSi CCDS23178.1.
PIRi S53524.
RefSeqi NP_032022.1. NM_007996.1.
UniGenei Mm.1061.
Mm.440190.

3D structure databases

ProteinModelPortali P46656.
SMRi P46656. Positions 65-172.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-1861080.

PTM databases

PhosphoSitei P46656.

Proteomic databases

MaxQBi P46656.
PaxDbi P46656.
PRIDEi P46656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034552 ; ENSMUSP00000034552 ; ENSMUSG00000032051 .
GeneIDi 14148.
KEGGi mmu:14148.
UCSCi uc009plo.1. mouse.

Organism-specific databases

CTDi 2230.
MGIi MGI:103224. Fdx1.

Phylogenomic databases

eggNOGi COG0633.
HOGENOMi HOG000244518.
HOVERGENi HBG000092.
InParanoidi P46656.
OMAi ARQSVDM.
OrthoDBi EOG708W1D.
PhylomeDBi P46656.
TreeFami TF319845.

Enzyme and pathway databases

Reactomei REACT_196619. Electron transport from NADPH to Ferredoxin.
REACT_199053. Mitochondrial iron-sulfur cluster biogenesis.

Miscellaneous databases

NextBioi 285254.
PROi P46656.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46656.
Bgeei P46656.
CleanExi MM_FDX1.
Genevestigatori P46656.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
[Graphical view ]
Pfami PF00111. Fer2. 1 hit.
[Graphical view ]
PRINTSi PR00355. ADRENODOXIN.
SUPFAMi SSF54292. SSF54292. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.
  2. "Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin."
    Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T.
    Biochim. Biophys. Acta 1263:173-175(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Kidney.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADX_MOUSE
AccessioniPrimary (citable) accession number: P46656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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