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Protein

Homeobox protein knotted-1-like 1

Gene

KNAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state, and its expression disappears at the same time the shoot apex undergoes the transition from vegetative to reproductive development (PubMed:11934861). Positive regulator of LATERAL ORGAN BOUNDARIES (LOB) (PubMed:11934861). Probably binds to the DNA sequence 5'-TGAC-3' (PubMed:11934861). Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata (PubMed:12900451).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi300 – 363Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

  • cell fate commitment Source: TAIR
  • cell fate specification Source: TAIR
  • xylem and phloem pattern formation Source: TAIR
  • xylem development Source: TAIR
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein knotted-1-like 1
Alternative name(s):
Protein BREVIPEDICELLUS
Protein KNAT1
Gene namesi
Name:KNAT1
Synonyms:BP, BP1
Ordered Locus Names:At4g08150
ORF Names:F9M13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G08150.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489571 – 398Homeobox protein knotted-1-like 1Add BLAST398

Proteomic databases

PaxDbiP46639.

Expressioni

Tissue specificityi

Expressed in the vegetative meristem.2 Publications

Inductioni

Negatively regulated by ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2).

Gene expression databases

GenevisibleiP46639. AT.

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/BELL proteins BEL1, BLH2, BLH8/PNF and BLH9/PNY (PubMed:11701881, PubMed:12897247, PubMed:16741748, PubMed:17873098). Interacts with OFP1, OFP2, OFP4, OFP6 and OFP12 (PubMed:15781858). Interacts with CCT7 and CCT8 (PubMed:21868675). Interacts with KNATM-B (PubMed:18398054).7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BEL1Q388976EBI-530486,EBI-1153783
BLH9Q9LZM84EBI-530486,EBI-530473

Protein-protein interaction databases

BioGridi11664. 44 interactors.
IntActiP46639. 40 interactors.
STRINGi3702.AT4G08150.1.

Structurei

3D structure databases

ProteinModelPortaliP46639.
SMRiP46639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 299ELKPROSITE-ProRule annotationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 42Poly-Asn8
Compositional biasi51 – 57Poly-Asn7
Compositional biasi88 – 92Poly-Asn5
Compositional biasi121 – 127Poly-Asn7
Compositional biasi301 – 307Poly-Lys7

Sequence similaritiesi

Belongs to the TALE/KNOX homeobox family.PROSITE-ProRule annotation
Contains 1 ELK domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiP46639.
OMAiRENDPPE.
OrthoDBiEOG09360KEH.
PhylomeDBiP46639.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYQHDNST TPQRVSFLYS PISSSNKNDN TSDTNNNNNN NNSSNYGPGY
60 70 80 90 100
NNTNNNNHHH QHMLFPHMSS LLPQTTENCF RSDHDQPNNN NNPSVKSEAS
110 120 130 140 150
SSRINHYSML MRAIHNTQEA NNNNNDNVSD VEAMKAKIIA HPHYSTLLQA
160 170 180 190 200
YLDCQKIGAP PDVVDRITAA RQDFEARQQR STPSVSASSR DPELDQFMEA
210 220 230 240 250
YCDMLVKYRE ELTRPIQEAM EFIRRIESQL SMLCQSPIHI LNNPDGKSDN
260 270 280 290 300
MGSSDEEQEN NSGGETELPE IDPRAEDREL KNHLLKKYSG YLSSLKQELS
310 320 330 340 350
KKKKKGKLPK EARQKLLTWW ELHYKWPYPS ESEKVALAES TGLDQKQINN
360 370 380 390
WFINQRKRHW KPSEDMQFMV MDGLQHPHHA ALYMDGHYMG DGPYRLGP
Length:398
Mass (Da):45,836
Last modified:November 1, 1995 - v1
Checksum:i815A22786589A316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10T → S in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti10T → S in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti77E → D in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti92N → NN in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti92N → NN in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti125N → NN in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti125N → NN in AAM03026 (PubMed:11917137).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14174 Genomic DNA. Translation: AAA67881.1.
AF482994 mRNA. Translation: AAM03026.1.
AF482995 mRNA. Translation: AAM03027.1.
AC006267 Genomic DNA. Translation: AAD27897.1.
AL161510 Genomic DNA. Translation: CAB81151.1.
CP002687 Genomic DNA. Translation: AEE82597.1.
AY080834 mRNA. Translation: AAL87309.1.
AY113982 mRNA. Translation: AAM45030.1.
PIRiD85080.
RefSeqiNP_192555.1. NM_116884.4.
UniGeneiAt.28060.
At.72028.

Genome annotation databases

EnsemblPlantsiAT4G08150.1; AT4G08150.1; AT4G08150.
GeneIDi826364.
GrameneiAT4G08150.1; AT4G08150.1; AT4G08150.
KEGGiath:AT4G08150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14174 Genomic DNA. Translation: AAA67881.1.
AF482994 mRNA. Translation: AAM03026.1.
AF482995 mRNA. Translation: AAM03027.1.
AC006267 Genomic DNA. Translation: AAD27897.1.
AL161510 Genomic DNA. Translation: CAB81151.1.
CP002687 Genomic DNA. Translation: AEE82597.1.
AY080834 mRNA. Translation: AAL87309.1.
AY113982 mRNA. Translation: AAM45030.1.
PIRiD85080.
RefSeqiNP_192555.1. NM_116884.4.
UniGeneiAt.28060.
At.72028.

3D structure databases

ProteinModelPortaliP46639.
SMRiP46639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi11664. 44 interactors.
IntActiP46639. 40 interactors.
STRINGi3702.AT4G08150.1.

Proteomic databases

PaxDbiP46639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G08150.1; AT4G08150.1; AT4G08150.
GeneIDi826364.
GrameneiAT4G08150.1; AT4G08150.1; AT4G08150.
KEGGiath:AT4G08150.

Organism-specific databases

TAIRiAT4G08150.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiP46639.
OMAiRENDPPE.
OrthoDBiEOG09360KEH.
PhylomeDBiP46639.

Miscellaneous databases

PROiP46639.

Gene expression databases

GenevisibleiP46639. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKNAT1_ARATH
AccessioniPrimary (citable) accession number: P46639
Secondary accession number(s): Q8S3L9, Q8S3M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.