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Protein

Homeobox protein knotted-1-like 1

Gene

KNAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state, and its expression disappears at the same time the shoot apex undergoes the transition from vegetative to reproductive development (PubMed:11934861). Positive regulator of LATERAL ORGAN BOUNDARIES (LOB) (PubMed:11934861). Probably binds to the DNA sequence 5'-TGAC-3' (PubMed:11934861). Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata (PubMed:12900451).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi300 – 363Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • cell fate commitment Source: TAIR
  • cell fate specification Source: TAIR
  • xylem and phloem pattern formation Source: TAIR
  • xylem development Source: TAIR

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein knotted-1-like 1
Alternative name(s):
Protein BREVIPEDICELLUS
Protein KNAT1
Gene namesi
Name:KNAT1
Synonyms:BP, BP1
Ordered Locus Names:At4g08150
ORF Names:F9M13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G08150
TAIRilocus:2128828 AT4G08150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489571 – 398Homeobox protein knotted-1-like 1Add BLAST398

Proteomic databases

PaxDbiP46639
PRIDEiP46639

Expressioni

Tissue specificityi

Expressed in the vegetative meristem.2 Publications

Inductioni

Negatively regulated by ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2).

Gene expression databases

ExpressionAtlasiP46639 baseline and differential
GenevisibleiP46639 AT

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/BELL proteins BEL1, BLH2, BLH8/PNF and BLH9/PNY (PubMed:11701881, PubMed:12897247, PubMed:16741748, PubMed:17873098). Interacts with OFP1, OFP2, OFP4, OFP6 and OFP12 (PubMed:15781858). Interacts with CCT7 and CCT8 (PubMed:21868675). Interacts with KNATM-B (PubMed:18398054).7 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11664, 44 interactors
IntActiP46639, 76 interactors
STRINGi3702.AT4G08150.1

Structurei

3D structure databases

ProteinModelPortaliP46639
SMRiP46639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 299ELKPROSITE-ProRule annotationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 42Poly-Asn8
Compositional biasi51 – 57Poly-Asn7
Compositional biasi88 – 92Poly-Asn5
Compositional biasi121 – 127Poly-Asn7
Compositional biasi301 – 307Poly-Lys7

Sequence similaritiesi

Belongs to the TALE/KNOX homeobox family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOGENOMiHOG000272741
InParanoidiP46639
OMAiTQEANNN
OrthoDBiEOG09360KEH
PhylomeDBiP46639

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR005539 ELK_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR005540 KNOX1
IPR005541 KNOX2
PfamiView protein in Pfam
PF03789 ELK, 1 hit
PF05920 Homeobox_KN, 1 hit
PF03790 KNOX1, 1 hit
PF03791 KNOX2, 1 hit
SMARTiView protein in SMART
SM01188 ELK, 1 hit
SM00389 HOX, 1 hit
SM01255 KNOX1, 1 hit
SM01256 KNOX2, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51213 ELK, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYQHDNST TPQRVSFLYS PISSSNKNDN TSDTNNNNNN NNSSNYGPGY
60 70 80 90 100
NNTNNNNHHH QHMLFPHMSS LLPQTTENCF RSDHDQPNNN NNPSVKSEAS
110 120 130 140 150
SSRINHYSML MRAIHNTQEA NNNNNDNVSD VEAMKAKIIA HPHYSTLLQA
160 170 180 190 200
YLDCQKIGAP PDVVDRITAA RQDFEARQQR STPSVSASSR DPELDQFMEA
210 220 230 240 250
YCDMLVKYRE ELTRPIQEAM EFIRRIESQL SMLCQSPIHI LNNPDGKSDN
260 270 280 290 300
MGSSDEEQEN NSGGETELPE IDPRAEDREL KNHLLKKYSG YLSSLKQELS
310 320 330 340 350
KKKKKGKLPK EARQKLLTWW ELHYKWPYPS ESEKVALAES TGLDQKQINN
360 370 380 390
WFINQRKRHW KPSEDMQFMV MDGLQHPHHA ALYMDGHYMG DGPYRLGP
Length:398
Mass (Da):45,836
Last modified:November 1, 1995 - v1
Checksum:i815A22786589A316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10T → S in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti10T → S in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti77E → D in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti92N → NN in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti92N → NN in AAM03026 (PubMed:11917137).Curated1
Sequence conflicti125N → NN in AAM03027 (PubMed:11917137).Curated1
Sequence conflicti125N → NN in AAM03026 (PubMed:11917137).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14174 Genomic DNA Translation: AAA67881.1
AF482994 mRNA Translation: AAM03026.1
AF482995 mRNA Translation: AAM03027.1
AC006267 Genomic DNA Translation: AAD27897.1
AL161510 Genomic DNA Translation: CAB81151.1
CP002687 Genomic DNA Translation: AEE82597.1
AY080834 mRNA Translation: AAL87309.1
AY113982 mRNA Translation: AAM45030.1
PIRiD85080
RefSeqiNP_192555.1, NM_116884.4
UniGeneiAt.28060
At.72028

Genome annotation databases

EnsemblPlantsiAT4G08150.1; AT4G08150.1; AT4G08150
GeneIDi826364
GrameneiAT4G08150.1; AT4G08150.1; AT4G08150
KEGGiath:AT4G08150

Similar proteinsi

Entry informationi

Entry nameiKNAT1_ARATH
AccessioniPrimary (citable) accession number: P46639
Secondary accession number(s): Q8S3L9, Q8S3M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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