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P46638

- RB11B_MOUSE

UniProt

P46638 - RB11B_MOUSE

Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269GTPBy similarity
    Nucleotide bindingi66 – 705GTPBy similarity
    Nucleotide bindingi124 – 1274GTPBy similarity
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to acidic pH Source: UniProtKB
    2. constitutive secretory pathway Source: UniProtKB
    3. insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
    4. melanosome transport Source: UniProtKB
    5. receptor recycling Source: UniProtKB
    6. regulated secretory pathway Source: UniProtKB
    7. regulation of anion transport Source: UniProtKB
    8. regulation of endocytic recycling Source: UniProtKB
    9. regulation of protein localization to cell surface Source: UniProtKB
    10. retrograde transport, endosome to plasma membrane Source: UniProtKB
    11. small GTPase mediated signal transduction Source: InterPro
    12. transferrin transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-11B
    Gene namesi
    Name:Rab11b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:99425. Rab11b.

    Subcellular locationi

    Recycling endosome membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: MGI
    3. cytoplasmic membrane-bounded vesicle Source: MGI
    4. mitochondrion Source: MGI
    5. phagocytic vesicle Source: UniProtKB
    6. phagocytic vesicle membrane Source: UniProtKB-SubCell
    7. recycling endosome Source: UniProtKB
    8. recycling endosome membrane Source: UniProtKB
    9. synaptic vesicle Source: UniProtKB
    10. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi25 – 251S → N: Dominant negative mutant locked in the inactive GDP-bound form; partially relocalizes to the Golgi and alters endocytic recycling. 1 Publication
    Mutagenesisi70 – 701Q → L: Constitutively active mutant locked in the active GTP-bound form; alters endocytic recycling. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 215214Ras-related protein Rab-11BPRO_0000121159Add
    BLAST
    Propeptidei216 – 2183Removed in mature formSequence AnalysisPRO_0000370816

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei4 – 41Citrulline1 Publication
    Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity
    Modified residuei215 – 2151Cysteine methyl esterSequence Analysis
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.1 Publication

    Keywords - PTMi

    Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiP46638.
    PaxDbiP46638.
    PRIDEiP46638.

    PTM databases

    PhosphoSiteiP46638.

    Expressioni

    Tissue specificityi

    Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets.1 Publication

    Gene expression databases

    ArrayExpressiP46638.
    BgeeiP46638.
    CleanExiMM_RAB11B.
    GenevestigatoriP46638.

    Interactioni

    Subunit structurei

    Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 By similarity. May interact with TBC1D14 By similarity. Interacts with ATP6V1E1 By similarity. Interacts with KCNMA1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kcnma1C3VLD34EBI-1634944,EBI-6512684

    Protein-protein interaction databases

    BioGridi202532. 1 interaction.
    IntActiP46638. 5 interactions.
    MINTiMINT-1862423.

    Structurei

    3D structure databases

    ProteinModelPortaliP46638.
    SMRiP46638. Positions 8-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 489Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP46638.
    KOiK07905.
    OMAiIQVDAKT.
    OrthoDBiEOG7SFHZ2.
    PhylomeDBiP46638.
    TreeFamiTF300099.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46638-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT    50
    RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 100
    NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF 150
    IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV 200
    PPTTDGQRPN KLQCCQSL 218
    Length:218
    Mass (Da):24,489
    Last modified:January 23, 2007 - v3
    Checksum:i8DE0A98739EBD9FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26528 mRNA. Translation: AAC42093.1.
    BC054753 mRNA. Translation: AAH54753.1.
    BC085270 mRNA. Translation: AAH85270.1.
    CCDSiCCDS28628.1.
    PIRiA55005.
    RefSeqiNP_033023.1. NM_008997.3.
    UniGeneiMm.387587.

    Genome annotation databases

    EnsembliENSMUST00000057373; ENSMUSP00000110021; ENSMUSG00000077450.
    GeneIDi19326.
    KEGGimmu:19326.
    UCSCiuc008bzm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26528 mRNA. Translation: AAC42093.1 .
    BC054753 mRNA. Translation: AAH54753.1 .
    BC085270 mRNA. Translation: AAH85270.1 .
    CCDSi CCDS28628.1.
    PIRi A55005.
    RefSeqi NP_033023.1. NM_008997.3.
    UniGenei Mm.387587.

    3D structure databases

    ProteinModelPortali P46638.
    SMRi P46638. Positions 8-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202532. 1 interaction.
    IntActi P46638. 5 interactions.
    MINTi MINT-1862423.

    PTM databases

    PhosphoSitei P46638.

    Proteomic databases

    MaxQBi P46638.
    PaxDbi P46638.
    PRIDEi P46638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057373 ; ENSMUSP00000110021 ; ENSMUSG00000077450 .
    GeneIDi 19326.
    KEGGi mmu:19326.
    UCSCi uc008bzm.1. mouse.

    Organism-specific databases

    CTDi 9230.
    MGIi MGI:99425. Rab11b.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P46638.
    KOi K07905.
    OMAi IQVDAKT.
    OrthoDBi EOG7SFHZ2.
    PhylomeDBi P46638.
    TreeFami TF300099.

    Miscellaneous databases

    ChiTaRSi RAB11B. mouse.
    NextBioi 296291.
    PROi P46638.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46638.
    Bgeei P46638.
    CleanExi MM_RAB11B.
    Genevestigatori P46638.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein."
      Lai F., Stubbs L., Artzt K.
      Genomics 22:610-616(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Colon.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 5-24; 42-51; 62-72; 75-104; 111-125 AND 167-174, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Rab11b is essential for recycling of transferrin to the plasma membrane."
      Schlierf B., Fey G.H., Hauber J., Hocke G.M., Rosorius O.
      Exp. Cell Res. 259:257-265(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ENDOCYTIC RECYCLING, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF SER-25 AND GLN-70.
    5. "Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis."
      Sugawara K., Shibasaki T., Mizoguchi A., Saito T., Seino S.
      Genes Cells 14:445-456(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EXOCYTOSIS, TISSUE SPECIFICITY.
    6. "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking."
      Beaumont K.A., Hamilton N.A., Moores M.T., Brown D.L., Ohbayashi N., Cairncross O., Cook A.L., Smith A.G., Misaki R., Fukuda M., Taguchi T., Sturm R.A., Stow J.L.
      Traffic 12:627-643(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MELANOSOME TRANSPORT.
    7. "Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)."
      Butterworth M.B., Edinger R.S., Silvis M.R., Gallo L.I., Liang X., Apodaca G., Frizzell R.A., Fizzell R.A., Johnson J.P.
      Am. J. Physiol. 302:F581-F590(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b."
      Sokolowski S., Harvey M., Sakai Y., Jordan A., Sokolowski B.
      Biochem. Biophys. Res. Commun. 426:221-225(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNMA1.
    9. Cited for: CITRULLINATION AT ARG-4.

    Entry informationi

    Entry nameiRB11B_MOUSE
    AccessioniPrimary (citable) accession number: P46638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3