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P46638

- RB11B_MOUSE

UniProt

P46638 - RB11B_MOUSE

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Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. cellular response to acidic pH Source: UniProtKB
  2. constitutive secretory pathway Source: UniProtKB
  3. GTP catabolic process Source: GOC
  4. insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  5. melanosome transport Source: UniProtKB
  6. receptor recycling Source: UniProtKB
  7. regulated secretory pathway Source: UniProtKB
  8. regulation of anion transport Source: UniProtKB
  9. regulation of endocytic recycling Source: UniProtKB
  10. regulation of protein localization to cell surface Source: UniProtKB
  11. retrograde transport, endosome to plasma membrane Source: UniProtKB
  12. small GTPase mediated signal transduction Source: InterPro
  13. transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11B
Gene namesi
Name:Rab11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:99425. Rab11b.

Subcellular locationi

Recycling endosome membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. mitochondrion Source: MGI
  6. phagocytic vesicle Source: UniProtKB
  7. recycling endosome Source: UniProtKB
  8. recycling endosome membrane Source: UniProtKB
  9. synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251S → N: Dominant negative mutant locked in the inactive GDP-bound form; partially relocalizes to the Golgi and alters endocytic recycling. 1 Publication
Mutagenesisi70 – 701Q → L: Constitutively active mutant locked in the active GTP-bound form; alters endocytic recycling. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 215214Ras-related protein Rab-11BPRO_0000121159Add
BLAST
Propeptidei216 – 2183Removed in mature formSequence AnalysisPRO_0000370816

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei4 – 41Citrulline1 Publication
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity
Modified residuei215 – 2151Cysteine methyl esterSequence Analysis
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP46638.
PaxDbiP46638.
PRIDEiP46638.

PTM databases

PhosphoSiteiP46638.

Expressioni

Tissue specificityi

Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets.1 Publication

Gene expression databases

BgeeiP46638.
CleanExiMM_RAB11B.
ExpressionAtlasiP46638. baseline and differential.
GenevestigatoriP46638.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 (By similarity). May interact with TBC1D14 (By similarity). Interacts with ATP6V1E1 (By similarity). Interacts with KCNMA1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1C3VLD34EBI-1634944,EBI-6512684

Protein-protein interaction databases

BioGridi202532. 1 interaction.
IntActiP46638. 5 interactions.
MINTiMINT-1862423.

Structurei

3D structure databases

ProteinModelPortaliP46638.
SMRiP46638. Positions 8-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP46638.
KOiK07905.
OMAiIQVDAKT.
OrthoDBiEOG7SFHZ2.
PhylomeDBiP46638.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46638-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF
160 170 180 190 200
IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV
210
PPTTDGQRPN KLQCCQSL
Length:218
Mass (Da):24,489
Last modified:January 23, 2007 - v3
Checksum:i8DE0A98739EBD9FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26528 mRNA. Translation: AAC42093.1.
BC054753 mRNA. Translation: AAH54753.1.
BC085270 mRNA. Translation: AAH85270.1.
CCDSiCCDS28628.1.
PIRiA55005.
RefSeqiNP_033023.1. NM_008997.3.
UniGeneiMm.387587.

Genome annotation databases

EnsembliENSMUST00000057373; ENSMUSP00000110021; ENSMUSG00000077450.
GeneIDi19326.
KEGGimmu:19326.
UCSCiuc008bzm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26528 mRNA. Translation: AAC42093.1 .
BC054753 mRNA. Translation: AAH54753.1 .
BC085270 mRNA. Translation: AAH85270.1 .
CCDSi CCDS28628.1.
PIRi A55005.
RefSeqi NP_033023.1. NM_008997.3.
UniGenei Mm.387587.

3D structure databases

ProteinModelPortali P46638.
SMRi P46638. Positions 8-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202532. 1 interaction.
IntActi P46638. 5 interactions.
MINTi MINT-1862423.

PTM databases

PhosphoSitei P46638.

Proteomic databases

MaxQBi P46638.
PaxDbi P46638.
PRIDEi P46638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057373 ; ENSMUSP00000110021 ; ENSMUSG00000077450 .
GeneIDi 19326.
KEGGi mmu:19326.
UCSCi uc008bzm.1. mouse.

Organism-specific databases

CTDi 9230.
MGIi MGI:99425. Rab11b.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P46638.
KOi K07905.
OMAi IQVDAKT.
OrthoDBi EOG7SFHZ2.
PhylomeDBi P46638.
TreeFami TF300099.

Miscellaneous databases

ChiTaRSi Rab11b. mouse.
NextBioi 296291.
PROi P46638.
SOURCEi Search...

Gene expression databases

Bgeei P46638.
CleanExi MM_RAB11B.
ExpressionAtlasi P46638. baseline and differential.
Genevestigatori P46638.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein."
    Lai F., Stubbs L., Artzt K.
    Genomics 22:610-616(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Colon.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 5-24; 42-51; 62-72; 75-104; 111-125 AND 167-174, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Rab11b is essential for recycling of transferrin to the plasma membrane."
    Schlierf B., Fey G.H., Hauber J., Hocke G.M., Rosorius O.
    Exp. Cell Res. 259:257-265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOCYTIC RECYCLING, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF SER-25 AND GLN-70.
  5. "Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis."
    Sugawara K., Shibasaki T., Mizoguchi A., Saito T., Seino S.
    Genes Cells 14:445-456(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EXOCYTOSIS, TISSUE SPECIFICITY.
  6. "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking."
    Beaumont K.A., Hamilton N.A., Moores M.T., Brown D.L., Ohbayashi N., Cairncross O., Cook A.L., Smith A.G., Misaki R., Fukuda M., Taguchi T., Sturm R.A., Stow J.L.
    Traffic 12:627-643(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MELANOSOME TRANSPORT.
  7. "Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)."
    Butterworth M.B., Edinger R.S., Silvis M.R., Gallo L.I., Liang X., Apodaca G., Frizzell R.A., Fizzell R.A., Johnson J.P.
    Am. J. Physiol. 302:F581-F590(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b."
    Sokolowski S., Harvey M., Sakai Y., Jordan A., Sokolowski B.
    Biochem. Biophys. Res. Commun. 426:221-225(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNMA1.
  9. Cited for: CITRULLINATION AT ARG-4.

Entry informationi

Entry nameiRB11B_MOUSE
AccessioniPrimary (citable) accession number: P46638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3