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Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • myosin V binding Source: MGI

GO - Biological processi

  • cellular response to acidic pH Source: UniProtKB
  • constitutive secretory pathway Source: UniProtKB
  • establishment of protein localization to membrane Source: MGI
  • insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • melanosome transport Source: UniProtKB
  • receptor recycling Source: UniProtKB
  • regulated exocytosis Source: UniProtKB
  • regulation of anion transport Source: UniProtKB
  • regulation of endocytic recycling Source: UniProtKB
  • regulation of protein localization to cell surface Source: UniProtKB
  • retrograde transport, endosome to plasma membrane Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
  • transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11B
Gene namesi
Name:Rab11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99425. Rab11b.

Subcellular locationi

GO - Cellular componenti

  • aggresome Source: MGI
  • cell-cell adherens junction Source: MGI
  • cell junction Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • extracellular exosome Source: MGI
  • microtubule organizing center Source: MGI
  • mitochondrion Source: MGI
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
  • recycling endosome Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB
  • synaptic vesicle Source: UniProtKB
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25S → N: Dominant negative mutant locked in the inactive GDP-bound form; partially relocalizes to the Golgi and alters endocytic recycling. 1 Publication1
Mutagenesisi70Q → L: Constitutively active mutant locked in the active GTP-bound form; alters endocytic recycling. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211592 – 215Ras-related protein Rab-11BAdd BLAST214
PropeptideiPRO_0000370816216 – 218Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei4Citrulline1 Publication1
Lipidationi214S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterSequence analysis1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP46638.
PaxDbiP46638.
PeptideAtlasiP46638.
PRIDEiP46638.
TopDownProteomicsiP46638.

PTM databases

iPTMnetiP46638.
PhosphoSitePlusiP46638.

Expressioni

Tissue specificityi

Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets.1 Publication

Gene expression databases

BgeeiENSMUSG00000077450.
CleanExiMM_RAB11B.
ExpressionAtlasiP46638. baseline and differential.
GenevisibleiP46638. MM.

Interactioni

Subunit structurei

Interacts with KCNMA1 (PubMed:22935415). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with ATP6V1E1. Interacts with PI4KB (By similarity). Interacts (GDP-bound form) with ZFYVE27. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1C3VLD34EBI-1634944,EBI-6512684

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202532. 2 interactors.
IntActiP46638. 14 interactors.
MINTiMINT-1862423.
STRINGi10090.ENSMUSP00000110021.

Structurei

3D structure databases

ProteinModelPortaliP46638.
SMRiP46638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP46638.
KOiK07905.
OMAiETKQGCC.
OrthoDBiEOG091G0O1R.
PhylomeDBiP46638.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF
160 170 180 190 200
IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV
210
PPTTDGQRPN KLQCCQSL
Length:218
Mass (Da):24,489
Last modified:January 23, 2007 - v3
Checksum:i8DE0A98739EBD9FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26528 mRNA. Translation: AAC42093.1.
BC054753 mRNA. Translation: AAH54753.1.
BC085270 mRNA. Translation: AAH85270.1.
CCDSiCCDS28628.1.
PIRiA55005.
RefSeqiNP_033023.1. NM_008997.3.
UniGeneiMm.387587.

Genome annotation databases

EnsembliENSMUST00000057373; ENSMUSP00000110021; ENSMUSG00000077450.
GeneIDi19326.
KEGGimmu:19326.
UCSCiuc008bzm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26528 mRNA. Translation: AAC42093.1.
BC054753 mRNA. Translation: AAH54753.1.
BC085270 mRNA. Translation: AAH85270.1.
CCDSiCCDS28628.1.
PIRiA55005.
RefSeqiNP_033023.1. NM_008997.3.
UniGeneiMm.387587.

3D structure databases

ProteinModelPortaliP46638.
SMRiP46638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202532. 2 interactors.
IntActiP46638. 14 interactors.
MINTiMINT-1862423.
STRINGi10090.ENSMUSP00000110021.

PTM databases

iPTMnetiP46638.
PhosphoSitePlusiP46638.

Proteomic databases

EPDiP46638.
PaxDbiP46638.
PeptideAtlasiP46638.
PRIDEiP46638.
TopDownProteomicsiP46638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057373; ENSMUSP00000110021; ENSMUSG00000077450.
GeneIDi19326.
KEGGimmu:19326.
UCSCiuc008bzm.1. mouse.

Organism-specific databases

CTDi9230.
MGIiMGI:99425. Rab11b.

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP46638.
KOiK07905.
OMAiETKQGCC.
OrthoDBiEOG091G0O1R.
PhylomeDBiP46638.
TreeFamiTF300099.

Miscellaneous databases

ChiTaRSiRab11b. mouse.
PROiP46638.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000077450.
CleanExiMM_RAB11B.
ExpressionAtlasiP46638. baseline and differential.
GenevisibleiP46638. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB11B_MOUSE
AccessioniPrimary (citable) accession number: P46638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.