Ras-related protein Rab-11B precursor

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P46638 (RB11B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-11B

Gene names

Name:

Rab11b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis By similarity.
Subunit structure	Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 By similarity. May interact with TBC1D14 By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.
Tissue specificity	Abundantly expressed in brain, heart and testis.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Cell cycle Protein transport Transport
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Lipoprotein Methylation Prenylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW melanosome transport Inferred from mutant phenotype PubMed 21291502. Source: UniProtKB regulation of endocytic recycling Inferred from mutant phenotype PubMed 10942597. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro transferrin transport Inferred from mutant phenotype PubMed 10942597. Source: UniProtKB
Cellular_component	mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI phagocytic vesicle Inferred from sequence or structural similarity. Source: UniProtKB phagocytic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell recycling endosome membrane Inferred from direct assay PubMed 10942597. Source: UniProtKB
Molecular_function	GDP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from direct assay PubMed 10942597. Source: UniProtKB GTPase activity Inferred from mutant phenotype PubMed 10942597. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Kcnma1	C3VLD3	4	EBI-1634944,EBI-6512684

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 215

214

Ras-related protein Rab-11B

PRO_0000121159

Propeptide

216 – 218

Removed in mature form Potential

PRO_0000370816

Regions

Nucleotide binding

18 – 26

GTP By similarity

Nucleotide binding

66 – 70

GTP By similarity

Nucleotide binding

124 – 127

GTP By similarity

Nucleotide binding

154 – 156

GTP By similarity

Motif

40 – 48

Effector region By similarity

Amino acid modifications

Modified residue

N-acetylglycine By similarity

Modified residue

215

Cysteine methyl ester Potential

Lipidation

214

S-geranylgeranyl cysteine By similarity

Lipidation

215

S-geranylgeranyl cysteine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P46638 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 8DE0A98739EBD9FF
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FASTA

218

24,489

        10         20         30         40         50         60 
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI 

        70         80         90        100        110        120 
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM 

       130        140        150        160        170        180 
LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF IETSALDSTN VEEAFKNILT EIYRIVSQKQ 

       190        200        210 
IADRAAHDES PGNNVVDISV PPTTDGQRPN KLQCCQSL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein." Lai F., Stubbs L., Artzt K. Genomics 22:610-616(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and FVB/N. Tissue: Brain and Colon.
[3]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-24; 42-51; 62-72; 75-104; 111-125 AND 167-174, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26528 mRNA. Translation: AAC42093.1. BC054753 mRNA. Translation: AAH54753.1. BC085270 mRNA. Translation: AAH85270.1.
IPI	IPI00135869.
PIR	A55005.
RefSeq	NP_033023.1. NM_008997.3.
UniGene	Mm.387587.
3D structure databases
ProteinModelPortal	P46638.
SMR	P46638. Positions 8-188.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46638. 2 interactions.
PTM databases
PhosphoSite	P46638.
Proteomic databases
PaxDb	P46638.
PRIDE	P46638.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000057373; ENSMUSP00000110021; ENSMUSG00000077450.
GeneID	19326.
KEGG	mmu:19326.
Organism-specific databases
CTD	9230.
MGI	MGI:99425. Rab11b.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	P46638.
KO	K07905.
OMA	ERSAHDE.
OrthoDB	EOG4RR6J7.
Gene expression databases
ArrayExpress	P46638.
Bgee	P46638.
CleanEx	MM_RAB11B.
Genevestigator	P46638.
GermOnline	ENSMUSG00000002290. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RAB11B. mouse.
NextBio	296291.
SOURCE	Search...

Entry information

Entry name

RB11B_MOUSE

Accession

Primary (citable) accession number: P46638

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents