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P46633

- HS90A_CRIGR

UniProt

P46633 - HS90A_CRIGR

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Protein

Heat shock protein HSP 90-alpha

Gene
HSP90AA1, HSP90A, HSPCA
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function By similarity. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511ATP By similarity
Binding sitei93 – 931ATP By similarity
Binding sitei112 – 1121ATP By similarity
Binding sitei138 – 1381ATP; via amide nitrogen By similarity
Binding sitei401 – 4011ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nitric-oxide synthase regulator activity Source: UniProtKB
  3. TPR domain binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of nitric oxide biosynthetic process Source: UniProtKB
  2. protein folding Source: InterPro
  3. regulation of catalytic activity Source: GOC
  4. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein HSP 90-alpha
Gene namesi
Name:HSP90AA1
Synonyms:HSP90A, HSPCA
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cytoplasm By similarity. Melanosome By similarity. Cell membrane By similarity UniRule annotation

GO - Cellular componenti

  1. melanosome Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 733732Heat shock protein HSP 90-alphaUniRule annotationPRO_0000062909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Phosphothreonine; by PRKDC By similarity
Modified residuei7 – 71Phosphothreonine; by PRKDC By similarity
Modified residuei58 – 581N6-acetyllysine By similarity
Modified residuei84 – 841N6-acetyllysine By similarity
Modified residuei231 – 2311Phosphoserine By similarity
Modified residuei263 – 2631Phosphoserine By similarity
Modified residuei314 – 3141Phosphotyrosine By similarity
Modified residuei400 – 4001Phosphoserine By similarity
Modified residuei444 – 4441N6-acetyllysine By similarity
Modified residuei459 – 4591N6-acetyllysine By similarity
Modified residuei490 – 4901N6-acetyllysine By similarity
Modified residuei493 – 4931Phosphotyrosine By similarity
Modified residuei586 – 5861N6-acetyllysine By similarity
Modified residuei599 – 5991S-nitrosocysteine By similarity

Post-translational modificationi

S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1 By similarity.UniRule annotation
ISGylated By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

PRIDEiP46633.

Interactioni

Subunit structurei

Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems By similarity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP46633.
SMRiP46633. Positions 9-223, 294-697.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni683 – 73351Required for homodimerization By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi729 – 7335TPR repeat-bindingUniRule annotation

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1 By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG007374.
KOiK04079.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46633-1 [UniParc]FASTAAdd to Basket

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MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS    50
NSSDALDKIR YESLTDPSKL DSGKELHINI IPNKQDRTLT IVDTGIGMTK 100
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYT AYLVAEKVTV 150
ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYMEE 200
RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK 250
GIDDKPEIED VGSDEEEEEK KDGDKKKKKK IKEKYIDQEE LNKTKPIWTR 300
NPDDITNEEY GEFYKSLTND WEEHLAVKHF SVEGQLEFRA LLFVPRRAPF 350
DLFENRKKKN NIKLYVRRVF IMDNCEELFP EYLNFIRGVV DSEDLPLNIS 400
REILQQSKIL KVIRKNLVRK CLELFHELAE DKENYKKFYE QFSKNIKLGI 450
HEDSQNRKKL SELLRYYTSA SGDEMVSLKD YCTRMKENQK HIYFITGETK 500
DQVANSAFVE RLRKHGLEVI YMIEPIDEYC VQQLKEFEGK TLVSVTKEGL 550
ELPEDEEEKK KQEEKKTKFE NLCKIMKDIL EKKVEKVVVS NRLVTSPCCI 600
VTSTYGWTAN MERIIKAQAL RDNSTMGYMA AKKHLEINPD HSIIETLRQK 650
AEADKNDKSV KDLVILLYET ALLSSGFSLE DPQTHANRIY RMIKLGLGID 700
EDDPTVDDTS AAVTEEMPPL EGDDDTSRME EVD 733
Length:733
Mass (Da):84,849
Last modified:January 23, 2007 - v2
Checksum:i95EECAFD0E410057
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33676 mRNA. Translation: AAA36992.1.
RefSeqiNP_001233750.1. NM_001246821.1.

Genome annotation databases

GeneIDi100689397.
KEGGicge:100689397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33676 mRNA. Translation: AAA36992.1 .
RefSeqi NP_001233750.1. NM_001246821.1.

3D structure databases

ProteinModelPortali P46633.
SMRi P46633. Positions 9-223, 294-697.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689397.
KEGGi cge:100689397.

Organism-specific databases

CTDi 3320.

Phylogenomic databases

HOVERGENi HBG007374.
KOi K04079.

Family and domain databases

Gene3Di 3.30.565.10. 2 hits.
HAMAPi MF_00505. HSP90.
InterProi IPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view ]
PIRSFi PIRSF002583. Hsp90. 1 hit.
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS00298. HSP90. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a cDNA clone encoding HSP90A from Chinese hamster cells."
    Chen M.-S.M.C., Laszlo A.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHS90A_CRIGR
AccessioniPrimary (citable) accession number: P46633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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