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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name:
ACT-2
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:SCYA4
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000005168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019709.

Structurei

3D structure databases

ProteinModelPortaliP46632.
SMRiP46632. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP46632.
KOiK12964.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGVTVLSV ALLVAALCPP ALSAPMGSDP PTACCFSYTL RKLPRHFVID
60 70 80 90
YFETTSLCSQ PAVVFQTKKG RQVCANPSES WVQEYVDDLE LN
Length:92
Mass (Da):10,066
Last modified:November 1, 1995 - v1
Checksum:iECBA8818D42A735C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17402 mRNA. Translation: BAA04226.1.
PIRiI46730.
RefSeqiNP_001075665.1. NM_001082196.1.
UniGeneiOcu.2141.

Genome annotation databases

GeneIDi100008984.
KEGGiocu:100008984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17402 mRNA. Translation: BAA04226.1.
PIRiI46730.
RefSeqiNP_001075665.1. NM_001082196.1.
UniGeneiOcu.2141.

3D structure databases

ProteinModelPortaliP46632.
SMRiP46632. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008984.
KEGGiocu:100008984.

Organism-specific databases

CTDi6351.

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP46632.
KOiK12964.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dynamic changes in mRNA expression of neutrophils during the course of acute inflammation in rabbits."
    Mori S., Goto K., Goto F., Mutakami K., Ohkawara S., Yoshinaga M.
    Int. Immunol. 6:149-156(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.

Entry informationi

Entry nameiCCL4_RABIT
AccessioniPrimary (citable) accession number: P46632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.