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P46632

- CCL4_RABIT

UniProt

P46632 - CCL4_RABIT

Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Immune activation protein 2
    Short name:
    ACT-2
    Macrophage inflammatory protein 1-beta
    Short name:
    MIP-1-beta
    Small-inducible cytokine A4
    Gene namesi
    Name:CCL4
    Synonyms:SCYA4
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000005168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000019709.

    Structurei

    3D structure databases

    ProteinModelPortaliP46632.
    SMRiP46632. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46632-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLGVTVLSV ALLVAALCPP ALSAPMGSDP PTACCFSYTL RKLPRHFVID   50
    YFETTSLCSQ PAVVFQTKKG RQVCANPSES WVQEYVDDLE LN 92
    Length:92
    Mass (Da):10,066
    Last modified:November 1, 1995 - v1
    Checksum:iECBA8818D42A735C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17402 mRNA. Translation: BAA04226.1.
    PIRiI46730.
    RefSeqiNP_001075665.1. NM_001082196.1.
    UniGeneiOcu.2141.

    Genome annotation databases

    GeneIDi100008984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17402 mRNA. Translation: BAA04226.1 .
    PIRi I46730.
    RefSeqi NP_001075665.1. NM_001082196.1.
    UniGenei Ocu.2141.

    3D structure databases

    ProteinModelPortali P46632.
    SMRi P46632. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000019709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008984.

    Organism-specific databases

    CTDi 6351.

    Phylogenomic databases

    eggNOGi NOG124416.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamic changes in mRNA expression of neutrophils during the course of acute inflammation in rabbits."
      Mori S., Goto K., Goto F., Mutakami K., Ohkawara S., Yoshinaga M.
      Int. Immunol. 6:149-156(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.

    Entry informationi

    Entry nameiCCL4_RABIT
    AccessioniPrimary (citable) accession number: P46632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3