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Protein

T-cell surface glycoprotein CD4

Gene

CD4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell adhesion Source: InterPro
  • T cell differentiation Source: UniProtKB
  • T cell selection Source: UniProtKB

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD4
Alternative name(s):
T-cell surface antigen T4/Leu-3
CD_antigen: CD4
Gene namesi
Name:CD4
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 396ExtracellularSequence analysisAdd BLAST371
Transmembranei397 – 419HelicalSequence analysisAdd BLAST23
Topological domaini420 – 459CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001462826 – 459T-cell surface glycoprotein CD4Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 370PROSITE-ProRule annotation
Lipidationi420S-palmitoyl cysteineBy similarity1
Lipidationi423S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.By similarity
Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Forms disulfide-linked homo-dimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes.By similarity

Structurei

3D structure databases

ProteinModelPortaliP46630.
SMRiP46630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129Ig-like V-typeAdd BLAST104
Domaini130 – 208Ig-like C2-type 1Add BLAST79
Domaini209 – 318Ig-like C2-type 2Add BLAST110
Domaini319 – 374Ig-like C2-type 3Add BLAST56

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000008696.
HOVERGENiHBG005281.
InParanoidiP46630.
KOiK06454.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR000973. CD4.
IPR015274. CD4-extracel.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR021963. Tcell_CD4_Cterm.
PANTHERiPTHR11422:SF0. PTHR11422:SF0. 1 hit.
PfamiView protein in Pfam
PF05790. C2-set. 2 hits.
PF09191. CD4-extracel. 1 hit.
PF00047. ig. 1 hit.
PF12104. Tcell_CD4_C. 1 hit.
PRINTSiPR00692. CD4TCANTIGEN.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRRIYFQCL LLVLPLALLP AATWGKTVVR GKAGAIVELP CQSSQKRNSV
60 70 80 90 100
FNWKHANQVK ILGNQGSSSS SFWLKGNSPL SNRVESKKNM WDQGSFPLVI
110 120 130 140 150
KDLRMDDSGT YICEVGDKKM EVELLVFRLT ANPNTRLLHG QSLTLTLEGP
160 170 180 190 200
SVGSPSVQWK SPENKIIETG PTCSMPKLRL QDSGTWSCHL SFQDQNKLEL
210 220 230 240 250
DIKIIVLGFP KASATVYKKE GEQVEFSFPL NFEDESLSGE LMWQVDGASS
260 270 280 290 300
AQSWVSFSLE DRKVSVQKIL PDLKIQMSKG LPLSLTLPQA LHRYAGSGNL
310 320 330 340 350
SLTLDKGKLH QQVSLVMLKV TQVKNKLTCE VLGPIDPKMK LSLKLEDQEA
360 370 380 390 400
KVSTQKMVQV LDPKAGTWQC LLSSGDQVLL ESKADVLATG LSHQQPTLLA
410 420 430 440 450
GALGGTAGLV LFAGLCIYCC VKCRHRRHQA QRMSQIKKLL SEKKTCQCPH

RLQKTYNLL
Length:459
Mass (Da):50,886
Last modified:November 1, 1995 - v1
Checksum:iB323311CBD40013D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92840 mRNA. Translation: AAA31198.1.
PIRiA46254.
RefSeqiNP_001075782.1. NM_001082313.2.
UniGeneiOcu.1843.

Genome annotation databases

GeneIDi100009152.
KEGGiocu:100009152.

Similar proteinsi

Entry informationi

Entry nameiCD4_RABIT
AccessioniPrimary (citable) accession number: P46630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome