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Protein

Gastrin/cholecystokinin type B receptor

Gene

CCKBR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:CCKBR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 77Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini78 – 85CytoplasmicSequence analysis8
Transmembranei86 – 107Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini108 – 129ExtracellularSequence analysisAdd BLAST22
Transmembranei130 – 148Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini149 – 168CytoplasmicSequence analysisAdd BLAST20
Transmembranei169 – 187Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini188 – 217ExtracellularSequence analysisAdd BLAST30
Transmembranei218 – 240Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini241 – 338CytoplasmicSequence analysisAdd BLAST98
Transmembranei339 – 360Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini361 – 378ExtracellularSequence analysisAdd BLAST18
Transmembranei379 – 399Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini400 – 452CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694771 – 452Gastrin/cholecystokinin type B receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi125 ↔ 203PROSITE-ProRule annotation
Lipidationi413S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006740.

Structurei

3D structure databases

ProteinModelPortaliP46627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP46627.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVKLNRSV QGSGPVASLC RPGGPLLNNS GTGNLSCEPP RIRGAGTREL
60 70 80 90 100
ELAIRVTLYA VIFLMSVGGN ILIIVVLGLS RRLRTVTNAF LLSLAVSDLL
110 120 130 140 150
LAVACMPFTL LPNLMGTFIF GTVICKAVSY LMGVSVSVST LSLVAIALER
160 170 180 190 200
YSAICRPLQA RVWQTRSHAA RVILATWLLS GLLMVPYPVY TAVQPVGPRV
210 220 230 240 250
LQCVHRWPSA RVRQTWSVLL LLLLFFVPGV VMAVAYGLIS RELYLGLRFD
260 270 280 290 300
SDSDSESQSR VRGQGGLPGG AAPGPVHQNG RCRPEAGLAG EDGDGCYVQL
310 320 330 340 350
PRSRPALELS ALTAPISGPG PGPRPAQAKL LAKKRVVRML LVIVVLFFMC
360 370 380 390 400
WLPVYSANTW RAFDGPGAHR ALSGAPISFI HLLSYASACV NPLVYCFMHR
410 420 430 440 450
RFRQACLDTC ARCCPRPPRA RPRPLPDEDP PTPSIASLSR LSYTTISTLG

PG
Length:452
Mass (Da):48,730
Last modified:November 1, 1995 - v1
Checksum:iE0716FCC1DB38870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31548, L31547 Genomic DNA. Translation: AAA31194.1.
PIRiJC2459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31548, L31547 Genomic DNA. Translation: AAA31194.1.
PIRiJC2459.

3D structure databases

ProteinModelPortaliP46627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006740.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP46627.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGASR_RABIT
AccessioniPrimary (citable) accession number: P46627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.