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Protein

Gastrin/cholecystokinin type B receptor

Gene

CCKBR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:CCKBR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence analysisAdd
BLAST
Transmembranei56 – 7722Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 858CytoplasmicSequence analysis
Transmembranei86 – 10722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 12922ExtracellularSequence analysisAdd
BLAST
Transmembranei130 – 14819Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini149 – 16820CytoplasmicSequence analysisAdd
BLAST
Transmembranei169 – 18719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini188 – 21730ExtracellularSequence analysisAdd
BLAST
Transmembranei218 – 24023Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini241 – 33898CytoplasmicSequence analysisAdd
BLAST
Transmembranei339 – 36022Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini361 – 37818ExtracellularSequence analysisAdd
BLAST
Transmembranei379 – 39921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini400 – 45253CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Gastrin/cholecystokinin type B receptorPRO_0000069477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi125 ↔ 203PROSITE-ProRule annotation
Lipidationi413 – 4131S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006740.

Structurei

3D structure databases

ProteinModelPortaliP46627.
SMRiP46627. Positions 357-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP46627.
KOiK04195.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVKLNRSV QGSGPVASLC RPGGPLLNNS GTGNLSCEPP RIRGAGTREL
60 70 80 90 100
ELAIRVTLYA VIFLMSVGGN ILIIVVLGLS RRLRTVTNAF LLSLAVSDLL
110 120 130 140 150
LAVACMPFTL LPNLMGTFIF GTVICKAVSY LMGVSVSVST LSLVAIALER
160 170 180 190 200
YSAICRPLQA RVWQTRSHAA RVILATWLLS GLLMVPYPVY TAVQPVGPRV
210 220 230 240 250
LQCVHRWPSA RVRQTWSVLL LLLLFFVPGV VMAVAYGLIS RELYLGLRFD
260 270 280 290 300
SDSDSESQSR VRGQGGLPGG AAPGPVHQNG RCRPEAGLAG EDGDGCYVQL
310 320 330 340 350
PRSRPALELS ALTAPISGPG PGPRPAQAKL LAKKRVVRML LVIVVLFFMC
360 370 380 390 400
WLPVYSANTW RAFDGPGAHR ALSGAPISFI HLLSYASACV NPLVYCFMHR
410 420 430 440 450
RFRQACLDTC ARCCPRPPRA RPRPLPDEDP PTPSIASLSR LSYTTISTLG

PG
Length:452
Mass (Da):48,730
Last modified:November 1, 1995 - v1
Checksum:iE0716FCC1DB38870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31548, L31547 Genomic DNA. Translation: AAA31194.1.
PIRiJC2459.

Genome annotation databases

KEGGiocu:100328939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31548, L31547 Genomic DNA. Translation: AAA31194.1.
PIRiJC2459.

3D structure databases

ProteinModelPortaliP46627.
SMRiP46627. Positions 357-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006740.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiocu:100328939.

Organism-specific databases

CTDi887.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP46627.
KOiK04195.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGASR_RABIT
AccessioniPrimary (citable) accession number: P46627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.