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Protein

Beta-3 adrenergic receptor

Gene

ADRB3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Agonist or antagonistBy similarity1
Binding sitei122Agonist or antagonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-390696. Adrenoceptors.
R-BTA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
Gene namesi
Name:ADRB3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
Transmembranei37 – 63Helical; Name=1By similarityAdd BLAST27
Topological domaini64 – 72CytoplasmicBy similarity9
Transmembranei73 – 91Helical; Name=2By similarityAdd BLAST19
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 133Helical; Name=3By similarityAdd BLAST22
Topological domaini134 – 155CytoplasmicBy similarityAdd BLAST22
Transmembranei156 – 178Helical; Name=4By similarityAdd BLAST23
Topological domaini179 – 203ExtracellularBy similarityAdd BLAST25
Transmembranei204 – 225Helical; Name=5By similarityAdd BLAST22
Topological domaini226 – 292CytoplasmicBy similarityAdd BLAST67
Transmembranei293 – 314Helical; Name=6By similarityAdd BLAST22
Topological domaini315 – 326ExtracellularBy similarityAdd BLAST12
Transmembranei327 – 347Helical; Name=7By similarityAdd BLAST21
Topological domaini348 – 405CytoplasmicBy similarityAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691381 – 405Beta-3 adrenergic receptorAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 196PROSITE-ProRule annotation
Disulfide bondi189 ↔ 195PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP46626.
PRIDEiP46626.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017981.

Interactioni

Subunit structurei

Interacts with ARRDC3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023923.

Structurei

3D structure databases

ProteinModelPortaliP46626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 212Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni305 – 312Agonist and antagonist bindingBy similarity8
Regioni332 – 336Agonist and antagonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP46626.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPWPPGNSS LTPWPDIPTL APNTANASGL PGVPWAVALA GALLALAVLA
60 70 80 90 100
TVGGNLLVIV AIARTPRLQT MTNVFVTSLA TADLVVGLLV VPPGATLALT
110 120 130 140 150
GHWPLGVTGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT
160 170 180 190 200
KRRALAAVVL VWVVSAAVSF APIMSKWWRI GADAEAQRCH SNPRCCTFAS
210 220 230 240 250
NMPYALLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRR ELGRFPPEES
260 270 280 290 300
PPAPSRSGSP GLAGPCASPA GVPSYGRRPA RLLPLREHRA LRTLGLIMGT
310 320 330 340 350
FTLCWLPFFV VNVVRALGGP SLVSGPTFLA LNWLGYANSA FNPLIYCRSP
360 370 380 390 400
DFRSAFRRLL CRCRPEEHLA AASPPRAPSG APTALTSPAG PMQPPELDGA

SCGLS
Length:405
Mass (Da):42,903
Last modified:November 1, 1995 - v1
Checksum:iC93667DC1CC286F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 7PG → HE in CAA47654 (Ref. 4) Curated2
Sequence conflicti156A → T (PubMed:7904157).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85961 mRNA. Translation: CAA59937.1.
AF109930 Genomic DNA. Translation: AAD26149.1.
BC116092 mRNA. Translation: AAI16093.1.
X67214 Genomic DNA. Translation: CAA47654.1.
PIRiS65459.
RefSeqiNP_776657.1. NM_174232.2.
UniGeneiBt.318.

Genome annotation databases

EnsembliENSBTAT00000023923; ENSBTAP00000023923; ENSBTAG00000017981.
GeneIDi281606.
KEGGibta:281606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85961 mRNA. Translation: CAA59937.1.
AF109930 Genomic DNA. Translation: AAD26149.1.
BC116092 mRNA. Translation: AAI16093.1.
X67214 Genomic DNA. Translation: CAA47654.1.
PIRiS65459.
RefSeqiNP_776657.1. NM_174232.2.
UniGeneiBt.318.

3D structure databases

ProteinModelPortaliP46626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023923.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP46626.
PRIDEiP46626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023923; ENSBTAP00000023923; ENSBTAG00000017981.
GeneIDi281606.
KEGGibta:281606.

Organism-specific databases

CTDi155.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP46626.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-BTA-390696. Adrenoceptors.
R-BTA-418555. G alpha (s) signalling events.

Gene expression databases

BgeeiENSBTAG00000017981.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRB3_BOVIN
AccessioniPrimary (citable) accession number: P46626
Secondary accession number(s): Q1LZC1, Q28045, Q9TS17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.