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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:ADORA2A
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4ExtracellularBy similarity4
Transmembranei5 – 29Helical; Name=1By similarityAdd BLAST25
Topological domaini30 – 39CytoplasmicBy similarity10
Transmembranei40 – 63Helical; Name=2By similarityAdd BLAST24
Topological domaini64 – 74ExtracellularBy similarityAdd BLAST11
Transmembranei75 – 97Helical; Name=3By similarityAdd BLAST23
Topological domaini98 – 117CytoplasmicBy similarityAdd BLAST20
Transmembranei118 – 140Helical; Name=4By similarityAdd BLAST23
Topological domaini141 – 170ExtracellularBy similarityAdd BLAST30
Transmembranei171 – 195Helical; Name=5By similarityAdd BLAST25
Topological domaini196 – 231CytoplasmicBy similarityAdd BLAST36
Transmembranei232 – 255Helical; Name=6By similarityAdd BLAST24
Topological domaini256 – 263ExtracellularBy similarity8
Transmembranei264 – 287Helical; Name=7By similarityAdd BLAST24
Topological domaini288 – 409CytoplasmicBy similarityAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689971 – 409Adenosine receptor A2aAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 156PROSITE-ProRule annotation
Disulfide bondi71 ↔ 143PROSITE-ProRule annotation
Disulfide bondi74 ↔ 163PROSITE-ProRule annotation
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 259PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. Interacts with NECAB2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000018786.

Chemistry databases

BindingDBiP46616.

Structurei

3D structure databases

ProteinModelPortaliP46616.
SMRiP46616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 174Agonist bindingBy similarity10
Regioni243 – 250Agonist bindingBy similarity8
Regioni261 – 271Agonist bindingBy similarityAdd BLAST11

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP46616.

Family and domain databases

CDDicd15068. 7tmA_Adenosine_R_A2A. 1 hit.
InterProiView protein in InterPro
IPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24246:SF32. PTHR24246:SF32. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVYITVE LVIAVLAILG NVLVCWAVWI NSNLQNVTNY FVVSLAAADI
60 70 80 90 100
AVGVLAIPFA ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLTITIDRY
110 120 130 140 150
IAIRIPLRYN GLVTCTRAKG IIAICWVLSF AIGLTPMLGW NNCSQPKGDK
160 170 180 190 200
NHSESCDEGQ VTCLFEDVVP MNYMVYYNFF AFVLVPLLLM LGIYLRIFLA
210 220 230 240 250
ARRQLKQMES QPLPGERTRS TLQKEVHPAK SLAIIVGLFA LCCLPLNIIN
260 270 280 290 300
CFTFFCPECD HAPPWLMYLT IILSHGNSVV NPLIYAYRIR EFRQTFRKII
310 320 330 340 350
RSHILRRREL FKAGGTSARA SAAHSPEGEQ VSLRLNGHPP GVWANGSALR
360 370 380 390 400
PEQRPNGYVL GLVSGRSAQR SHGDASLSDV ELLSHEHKGT CPESPSLEDP

PAHGGAGVS
Length:409
Mass (Da):44,943
Last modified:November 1, 1995 - v1
Checksum:iC4263E63B9000633
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94T → A (PubMed:8065518).Curated1
Sequence conflicti96T → A (PubMed:8065518).Curated1
Sequence conflicti228P → A in AAA18421 (PubMed:8065518).Curated1
Sequence conflicti243C → W in AAA18421 (PubMed:8065518).Curated1
Sequence conflicti247N → H in AAA18421 (PubMed:8065518).Curated1
Sequence conflicti260D → G in AAA18421 (PubMed:8065518).Curated1
Sequence conflicti268 – 269YL → SM in AAA18421 (PubMed:8065518).Curated2
Sequence conflicti349L → P in AAA18421 (PubMed:8065518).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63674 mRNA. Translation: BAA09825.1.
U04201 mRNA. Translation: AAA18421.1.
PIRiI48095.
S68247.
RefSeqiNP_001166204.1. NM_001172733.1.

Genome annotation databases

GeneIDi100135473.

Similar proteinsi

Entry informationi

Entry nameiAA2AR_CAVPO
AccessioniPrimary (citable) accession number: P46616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families